Born an educated in France, Marie came under the influence of Jean Martin Charcot and studied and worked at the Salpetriere. He was identified as a neuropathologist quite early in his career publishing on observations on nerve entities which he recognized and named such as progressive muscular atrophy (with Charcot). He was much interested in multiple sclerosis, hypertrophic osteoarthropathy, cerebellar heredoataxia, and spondylosis with nerve involvements. He was at odds with Broca, even engaged Babinski and the Dejerines (husband and wife) in controversies. His work on acromegaly was classical. His work on diseases of the spinal cord is monumental.

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