Born in the United States, Papez after receiving his MD at the University of Minnesota College of Medicine and Surgery entered into neuroanatomy training and authored his book "Comparative Neurology" in 1929 patterned after his famous course of neuroanatomy when he later worked at Cornell in Ithaca, New York. He was a great teacher as he was a writer. A great interest was paralysis in which he studied the neuropathology. He conceived a "mechanism of emotion" (hypocampo-thalamo-cingulate-hippocampal circuit). Papez will be remembered as one of the great neuroanatomists of all time.

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