835 S. Wolcott Ave., (M/C 901)
Chicago, IL 60612-7342
312-996-7620 phone
312-996-1414 fax
835 S. Wolcott Ave., (M/C 901)
Chicago, IL 60612-7342
312-996-7620 phone
312-996-1414 fax
Jonna Frasor, Ph.D.
Assistant Professor
Selected Publications:
Frasor J, Barnett DH, Danes JM, Hess R, Parlow AF, Katzenellenbogen BS. 2003 Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) alpha activity by ERbeta in the uterus. Endocrinology 144:3159-3166.
Frasor J, Danes JM, Komm B, Chang KC, Lyttle CR, Katzenellenbogen BS. 2003 Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology 144:4562-4574.
Frasor J, Stossi F, Danes JM, Komm B, Lyttle CR, Katzenellenbogen BS. 2004 Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells. Cancer Res 64:1522-1533.
Frasor J, Danes JM, Funk CC, Katzenellenbogen BS. 2005 Estrogen down-regulation of the corepressor N-CoR: mechanism and implications for estrogen derepression of N-CoR-regulated genes. Proc Natl Acad Sci U S A 102:13153-13157.
Chang EC, Frasor J, Komm B, Katzenellenbogen BS. 2006 Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells. Endocrinology 147:4831-4842.
Frasor J, Chang EC, Komm B, Lin CY, Vega VB, Liu ET, Miller LD, Smeds J, Bergh J, Katzenellenbogen BS. 2006 Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Res 66:7334-7340.
Stender JD, Frasor J, Komm B, Chang KC, Kraus WL, Katzenellenbogen BS. 2007 Estrogen-regulated gene networks in human breast cancer cells: involvement of E2F1 in the regulation of cell proliferation. Mol Endocrinol 21:2112-2123.
Frasor J, Weaver AE, Pradhan M, Mehta K. 2008 Synergistic up-regulation of prostaglandin E synthase expression in breast cancer cells by estrogen and pro-inflammatory cytokines. Endocrinology 149:6272-9.
Frasor J, Weaver A, Pradhan M, Dai Y, Miller LD, Lin C-Y, Stanculescu S. 2009 Positive cross-talk between estrogen receptor and NF-κB in breast cancer. Cancer Res 69:8918–25.
Stanculescu A, Bembinster LA, Borgen K, Bergamaschi A, Wiley E, Frasor J. 2010 Estrogen promotes breast cancer cell survival in an inhibitor of apoptosis (IAP)-dependent manner. Horm Canc 1:127-135.
Pradhan M, Bembinster LA, Baumgarten SC, Frasor J. 2010 Proinflammatory cytokines enhance estrogen-dependent ABCG2 expression through estrogen receptor and NFkB cooperativity at adjacent response elements. J Biol Chem 285:31100-6
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11/08/10