Janusz H. Hankiewicz, Ph.D.

Research Assistant Professor
Nuclear Magnetic Resonance

Current Research Interest

Nuclear Magnetic Resonance
•localized spectroscopy

Magnetic Resonance microimaging
•cardiac imaging
•cardiac tagging
•myocardial strain analysis

Training and Positions

Ph.D.in Solid State NMR, A. Mickiewicz University in Poznan, Poland, 1988

Postdoctoral Fellow, Department of Chemistry and Texas Center for High Temperature Superconductivity, University of Houston, Houston, TX, 1991

Visiting Scholar, Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL, 1993

Assistant Professor, A. Mickiewicz University, Poznan, Poland, 1994-present

Research Assistant Professor, Department of Physiology and Biophysics, 1998-present

Program in Integrative Cardiac Metabolism, University of Illinois at Chicago, Chicago, IL, June 2003-present http://www.uic.edu/depts/mcpb/pages/lewandowski/IntegrativeCardiacMetabolism/index.htm

Equipment

Bruker AVANCE NMR spectrometer
- 14.1 T Bruker 89mm vertical bore magnet
- multinuclear console
- micro-imaging system with 100 Gs/cm gradient coils,
 
 
 
 

Some Experimental Results

   
Imaging of perfused rat heart. a) saggital localizer, b) axial image, c) myocardial wall motion between mid-diastole and mid-systole.
     
a)

b)

 c)
Tagged cardiac mid-ventricular axial images of a mouse heart using DANTE saturation and gradient-echo sequence: a) end diastolic and b) mid systolic, c) coronal localizer. Imaging parameters: TR=250ms, TE=1.9ms, FOV=25mm (axial images cropped to show 10x10mm area), acquisition matrix 256x256 (1024x1024 after reconstruction), slice thickness 1mm, acquisition time < 10min, tag grid spacing is 0.3mm.
     
a) b) c)
Tagged images data analysis: a) regional myocardial wall motion, b) map of E1 strain tensor, c) map of E2 strain tensor. Red and blue colors indicate stretch and shortening, respectively. Strain analysis program courtesy of Drs. Xin Yu and Wei Liu.
     

Selected publications from 2004

  1. Fiat D., Hankiewicz J., Siyuan Liu, Trbovic S., and Brint B. 17 O Magnetic Resonance Imaging of the Human Brain. Neurological Research 26: 803-808, 2004.
  2. Hankiewicz J.H., Lewandowski E.D. Improved cardiac tagging resolution at 14.1 T enables principal strain measurements in the LV wall of a mouse model of regional dilated cardiomyopathy. International Society for Magnetic Resonance in Medicine 14th Scientific Meeting, 2006; 684 (Abstract).
  3. Hankiewicz J.H. and Lewandowski E.D. Improved Cardiac Tagging Resolution at Ultra-High Magnetic Field Elucidates Transmural Differences in Principal Strain in the Mouse Heart and Reduced Stretch in Dilated Cardiomyopathy. J Cardiovasc Magn Reson 9: 891-898, 2007.
  4. Hankiewicz J.H, Goldspink P.H., Buttrick P.M. and Lewandowski E.D. Principal strain changes precede ventricular wall thinning during transition to heart failure in a mouse model of dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 294: H330-H336, 2008.
  5. Hankiewicz J.H., Hausler, Banke N. and Lewandowski E.D. Myocardial lipid accumulation due to high fat diet in PPAR a overexpressing mouse hearts reduces endocardial 2-D principal strains. International Society for Magnetic Resonance in Medicine 17 th Scientific Meeting, 2009; (accepted presentation).

E-mail: Janusz Hankiewicz, PhD
Telephone: 312-355-3715

03/11/09