835 S. Wolcott Ave., (M/C 901)
Chicago, IL 60612-7342
312-996-7620 phone
312-996-1414 fax
835 S. Wolcott Ave., (M/C 901)
Chicago, IL 60612-7342
312-996-7620 phone
312-996-1414 fax
Associate Professor and Director of Graduate Studies
Signal Transduction
Excitation-contraction coupling in skeletal and cardiac muscleThe overall goals of the research in Dr. García's laboratory are to determine the role of calcium channels in signal transduction in striated muscle and to elucidate how calcium regulates gene expression during cardiac cell growth. We recently found that the a2/d1 subunitis important for interactions of muscle cells with the extracellular matrix, representing a new role for this protein independent from its interactions with other channel subunits. Ongoing research is investigating the role of extracellular domains of the a2/d1 subunit as a chemical sensor and its transcriptional regulation during development and muscle repair of normal and dystrophic muscle.