Our focus is on the role of melatonin receptors in altering mammalian circadian rhythms. We use electrophysiological and pharmacological techniques to study and alter the “ticking” of the circadian clock located in the suprachiasmatic nucleus of the mammalian brain in both in vivo and in vitro models. We study the role of the G-protein coupled receptors, MT 1 and MT 2 , in setting the “phase” of the clock as well as coordinating peripheral oscillators.
Publications:
Hudson, R.L. and S.G. Schultz. 1984. Sodium-coupled sugar transport: Effects on intracellular sodium activities and sodium-pump activity. Science 224:1237-1239.
Hudson, R.L. and S.G. Schultz. 1988. Patch clamp studies revealing the activation of chloride channels in Ehrlich Ascites cells following exposure to glycine. Proc. Natl. Acad. Sci. 85:279-283.
Hudson, R.L. 1992. Ion transport by the isolated mantle epithelium of the freshwater clam, Unio complanatus. Am. J. Physiol. 263:R76-R83.
Hudson, R.L. 1993. Bafilomycin A1 sensitive acid secretion by the mantle epithelium of the freshwater clam, Unio complanatus . Am. J. Physiol. R946-R951.
Gerdin MJ, Masana MI, Rivera-Bermudez MA, Hudson RL, Earnest DJ, et al. 2004. Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin. Faseb J 18: 1646-56
Dubocovich ML, Hudson RL, Sumaya IC, Masana MI, Manna E. 2005. Effect of MT1 melatonin receptor deletion on melatonin-mediated phase shift of circadian rhythms in the C57BL/6 mouse. J Pineal Res 39: 113-20
09/14/07