As a member of the Program in Integrative Cardiac Metabolism, my laboratory is interested in the fundamental mechanisms responsible for the regulation of metabolism in healthy and diseased heart (diabetes, hypertrophy, heart failure, and ischemia/reperfusion). Mathematical models of cardiac metabolism are derived and fit to NMR data acquired from functioning hearts oxidizing 13 C labeled substrates. This gives metabolic activity and enzyme rates in parallel to measures of bioenergetics and function. Our studies have a mechanistic focus, and we are currently utilizing methods of gene transfer to manipulate the content of key regulatory enzymes in vivo. Our long-term goal is to identify targets for the therapeutic treatment of heart disease.
For more information on the Program in Integrative Cardiac Metabolism, see our homepage: http://www.heartmetabolism.uic.edu
Recent Publications:
O'Donnell JM, Zampino M, Alpert NM, Fasano MJ, Geenen DL, and Lewandowski ED. Accelerated Triacylglycerol Turnover Kinetics in Hearts of Diabetic Rats Include Evidence for Compartmented Lipid Storage. Amer J Physiol (Endocrin and Metab) Mar; 290(3): E448-55, 2006.
O'Donnell JM and ED Lewandowski. Controlling specificity and efficiency of adenoviral gene transfer in heart by catheter based coronary perfusion. In: Gene Therapy - Prospective assessment in its societal context. Niewohner & Tannert (Eds), Elsevier (pub) 2006, p.33-46 (Book Chapter).
Lewandowski ED, JM O'Donnell, TD Scholz, N Sorokina, and PM Buttrick. Recruitment of NADH Shuttling in Pressure Overloaded and Hypertrophic Rat Hearts. Amer J Physiol (Cell Physiology), 292(5): C1880-6, 2007.
Sorokina N, O'Donnell JM, McKinney RD, Pound KM, Woldegiorgis G, LaNoue KF, Ballal K, Taegtmeyer H, Buttrick PM, Lewandowski ED. Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts. Circulation. 155(15): 2033-41, 2007
09/10/07