835 S. Wolcott Ave., (M/C 901)
Chicago, IL 60612-7342
312-996-7620 phone
312-996-1414 fax
835 S. Wolcott Ave., (M/C 901)
Chicago, IL 60612-7342
312-996-7620 phone
312-996-1414 fax
Primal de Lanerolle, PhD
Professor
1. de Lanerolle, P. and Stull, J.T. Myosin phosphorylation during contraction and relaxation of tracheal smooth muscle. J. Biol. Chem. 255: 9993-10000, 1980.
2. de Lanerolle, P., Adelstein, R.S., Feramisco, J.R. and Burridge, K. Characterization of anti-bodies to smooth muscle myosin kinase and their use in localizing myosin kinase in non-muscle cells. Proc. Nat. Acad. Sci. USA 78: 4738-4742, 1981.
3. de Lanerolle, P., Condit, J.R., Tanenbaum, M. and Adelstein, R.S. Myosin phosphorylation, agonist concentration and contraction of tracheal smooth muscle. Nature 298: 871-872, 1982.
4. de Lanerolle, P., Nishikawa, M., Yost, D.A. and Adelstein, R.S. Increased phosphorylation of myosin light chain kinase after an increase in cyclic AMP in intact smooth muscle. Science 223: 1415-1417, 1984.
5. de Lanerolle, P. and Nishikawa, M. Regulation of fetal smooth muscle myosin by protein kinase C. J. Biol. Chem. 263: 9071-9074, 1988.
6. Wilson, A.K., Gorgas, G., Claypool, W.D. and de Lanerolle, P. An increase or a decrease in myosin II phosphorylation inhibits macrophage motility. J. Cell Biology 114: 277-283, 1991.
7. de Lanerolle, P. and Paul, R.J. Myosin phosphorylation/dephosphorylation and the regulation of airway muscle contractility. Am. J. Physiol. 258: L1-L14, 1991.
8. de Lanerolle, P., Gorgas, G., Li, X. and Schluns, K. Myosin light chain phosphorylation does not increase during yeast phagocytosis by macrophages. J. Biol. Chem. 268: 16,883-16,886, 1993.
9. Christensen, S., Verhage, H.G., Nowak, G., de Lanerolle, P., Fleming, S., Bell, S.C. Smooth muscle myosin II and alpha smooth muscle actin expression in the baboon (papio anubis) uterus is associated with glandular secretory activity and stromal cell transformation. Biology of Reproduction 53: 596-606, 1995.
10 Hecht, G.A., Pestic, L., Nikcevic, G., Koutsouris, A., Tripuraneni, J., Lorimer, D.D., Nowak, G., Guerriero, V., Elson, E. and de Lanerolle, P. Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability. Am. J. Physiol. 271: C1675-C1684, 1996.
11. Klemke, R.L., Cai, S., Giannini, A.L., Gallagher, P., de Lanerolle, P. and Cheresh, D.A. Regulation of cell motility by mitogen activated protein kinase. J. Cell Biol. 137: 481-492, 1997.
12. Nowak, G., Pestic-Dragovich, L., Hozak, P., Philimonenko, A., Simerly, C., Schatten, G. and de Lanerolle, P. Evidence for the presence of myosin I in the nucleus. J. Biol. Chem. 272: 17,176-17,181, 1997.
13. Majumdar, M., Seasholtz, T.M., Goldstein, D., de Lanerolle, P. and Brown, J.H. Thrombin-induced cell rounding is mediated through Rho and requires myosin light chain phosphorylation. J. Biol. Chem. 273: 10,099-10,106, 1998.
14. Cai, S., Pestic-Dragovich, L., O'Donnell, M.E., Wang, N., Ingber, D., Elson, E. and de Lanerolle, P. Regulation of cytoskeletal dynamics and cell growth by myosin light chain phosphorylation. Am. J. Physiol. 275: C1349-C1356, 1998.
15. Sanders, L., Matsumura, F., Bokoch, G.M. and de Lanerolle, P. Inhibition of myosin light chain kinase by p21-activated kinase (PAK) during cell spreading. Science 283: 2083-2085, 1999.
16. Pestic-Dragovich, L., Stojiljkovic, L., Philimonenko, A., Nowak, G., Ke, Y., Settlage, R.E., Shabanowitz, J., Hunt, D.F., Hozak, P. and de Lanerolle, P. A myosin I isoform in the nucleus. Science 290: 337-341, 2000
17. Qu., J., Cammarano, M.S., Shi, Q, Ha, K.C., de Lanerolle, P. and Minden, A. Activated PAK 4 regulates cell adhesion and anchorage independent growth. Mol. Cell. Biol. 21: 3523-33, 2001
18. Yuan, S.Y., Wu, M.H., Ustinova, E.E., Guo, M., Tinsley, J.H., de Lanerolle, P. and Xu, W. Myosin light chain phosphorylation in neutrophil-stimulated coronary microvascular leakage. Circulation Research 90: 1214-1221, 2002.
19. de Lanerolle, P. and Cole, A.B. Cytoskeletal proteins and gene regulation: Form, function and signal transduction in the nucleus. Science's STKE, http://www.stke.org/cgi/ content/full/sigtrans. July 2, 2002.
20. Hofmann, W.A., Ljuba Stojiljkovic, L., Fuchsova, B., Vargas, G.M., Mavrommatis, E., Philimonenko, V., Kysela, K., Goodrich, J.A., Lessard, J.L., Hope, T.J., Hozak, P. and de Lanerolle, P. Actin is part of pre-initiation complexes and necessary for transcription by RNA polymerase II. Nature Cell Biology 6: 1094-1101, 2004.
21. Philimonenko, V.V., Zhao, J., Iben, S., Dingova, H., Kysela, K., Kahle, M., Zentgraf, H., Hofmann, W.A., de Lanerolle, P., Hozak, P. and Grummt, I. Nuclear actin and myosin I are required for RNA polymerase I transcription. Nature Cell Biology 6: 1165-1172, 2004.
22. de Lanerolle, P. Top ten tips for success in graduate school. Nature 433: 442, 2005.
23. Fazal, F., Gu, L-Z., Ihnatovych, I., Han, YJ., Antic, N., Hu, W-Y., Carriera, F., Blomquist, J.F., Hope, T.J., Ucker, D. and de Lanerolle, P. Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo. Mol. Cell. Biology 25: 6259-6266, 2005.
24. de Lanerolle, P., Johnson, T. and Hofmann, W.A. Actin and myosin I in the nucleus: What next? Nature Struct. and Molec. Biol., 12: 292-296, 2005.
25. Chuang, C-H., Carpenter, A.E., Fuchsova, B., Johnson, T., de Lanerolle, P. and Belmont, A.S. Long-range directional movement of an interphase chromosome site. Current Biology 16: 825-831, 2006.
26. Gu, L., Hu, W-Y., Antic, N., Mehta, R., Turner. J.R. and de Lanerolle, P. Inhibiting Myosin Light Chain Kinase Retards the Growth of Mammary and Prostate Cancer Cells, In Vitro and In Vivo. European Journal of Cancer 42: 948-957, 2006. Epub Mar 30, 2006.
27. Hofmann, W.A., Vargas, G.M., Ramchandran, R., Stojiljkovic, L., Goodrich, J.A. and de Lanerolle, P. Nuclear myosin I is necessary for the formation of the first phosphodiester bond during transcription initiation by RNA polymerase II. J. Cellular Biochemistry , 99: 1001-1009, 2006.
28. Han, Y-J., Hu, W-Y., Antic, N., Gu, L., Gupta, M., Piano, M. and de Lanerolle, P. Increased myosin light chain kinase expression in hypertension: Regulation by SRF via an insertion mutation in the promoter. Molecular Biology of the Cell 17: 4039-4050, 2006.
29. Hu, W-Y., Han, Y-J., Gu, L-Z., Piano, M. and de Lanerolle, P. Involvement of myosin light chain phosphorylation in the captopril effects in spontaneously hypertensive rats. American Journal of Hypertension : 20: 53-61, 2007.
30. Ihnatovych, I., Hu, W-Y., Martin, J.L., Fazleabas, A.T., de Lanerolle, P. and Strakova, Z. Increased phosphorylation of myosin light chain prevents human uterine fibroblast decidualization, Endocrinology , 148: 3176-3184, 2007.
31. Han, Y-J. and de Lanerolle, P . Naturally extended CT.AG repeats increase H-DNA structures and histone modifications in the smooth muscle myosin light chain kinase promoter. Mol. Cell. Biology 28: 863-872, 2008.
32 Han, Y-J., Hu, W-Y., Piano, M. and de Lanerolle, P . Regulation of myosin light chain kinase expression by angiotensin II during vascular remodeling. American Journal of Hypertension, 21: 860-865, 2008.