835 S. Wolcott Ave., (M/C 901)
Chicago, IL 60612-7342
312-996-7620 phone
312-996-1414 fax

Mark M. Rasenick, PhD
Distinguished UIC Professor

Physiology and Biophysics, and Psychiatry
Director, Biomedical Neuroscience Training Program

Selected Publications:

Rasenick, M.M.  Gs (a poem).  Trends in Biochem. Sci. 17:71, 1992.

Rasenick, M.M. Where is the Light (a poem on depression)

Curriculum Vita

Video 1B

Video TIRF

1)  Popova, J.S., Garrison, J.C., Rhee, S.G. and RASENICK, M.M. Tubulin, Gq and phosphatidylinositol 4,5-bisphosphate interact to regulate phospholipase C 1 signaling. J. Biol. Chem. 272:6760-6765, 1997.

2)  Roychowdhury, S. and RASENICK, M.M. G-protein bg subnits regulate microtubule assembly.  J. Biol. Chem. 50:31576-31581, 1997.

3)  Roychowdhury, S., Panda, D., Wilson, L. and RASENICK, M.M.   G protein a subunits activate tubulin GTPase and modulate microtubule polymerization dynamics.  J. Biol. Chem. 274:13485-13490, 1999.

4)  Toki, S., Donati, R.J. and RASENICK, M.M.  Treatment of C6 Glioma cells and rats with antidepressant drugs increases the detergent extraction of Gsa from plasma membrane.  J. Neurochem. 73:1114-1120, 1999.

5)  Popova, J.S. and RASENICK, M.M.  Muscarinic receptor activation promotes the membrane association of tublin for the regulation of Gq-mediated phospholipase Cb1 signaling.  J. Neurosci. 20:2774-2782, 2000.

6)  Yan, K., Popova, J.S., Moss, A., Shah, B. and RASENICK, M.M.  Tubulin stimulates adenylyl cyclase activity in C6 glioma cells by bypassing the b-adrenergic receptor: a potential mechanism of G protein activation.  J. Neurochem., 76:182-190, 2001.

7)  Donati, R., Thukral, C. and RASENICK, M.M.  Chronic treatment of C6 glioma cells with antidepressant drugs results in a redistribution of Gsa.  Mol. Pharmacol., 59(6):1-7, 2001.

8)  Yu, J.Z. and RASENICK, M.M.  Real-time visualization of a fluorescent Gas: Dissociation of the activated G protein from the plasma membrane.  Mol. Pharmacol., 61:352-359, 2002.

9)  Yu, J.Z. and RASENICK, M.M.  Transient expression of fluorescent tau proteins promotes process formation in PC12 cells:  Contributions of the tau C-terminus to this process.  J. Neurosci. Res., 67:625-633, 2002.

10) Popova, J.S., Greene, A., Wang, J. and RASENICK, M.M.  Phophatidylinositol 4,5-bisphosphate modifies tubulin participation in PLCb1 signaling. J. Neuroscience, 22:1668-1678, 2002. 

11) Sarma, T., Voyno-Yasenetskaya, T., Hope, T.J. and RASENICK, M.M.  Heteotrimeric G proteins associate with microtubules during differentiation.  FASEB J., 17: 848-859, 2003.

12) Donati, R.J. and RASENICK, M.M. G protein signaling and the molecular basis of antidepressant action, (invited review). Life Sciences, 73:1-17, 2003.

13) Chen, N-F, Yu, J-Z, Skiba, N.P., Hamm, H.E. and RASENICK, M.M. A specific domain of Gi required for the transactivation of Gi by tubulin is implicated in the organization of cellular microtubules. J. Biol. Chem, 278: 15285-15290. 2003.

14) Popova, J.S. and RASENICK, M.M. G mediates the interplay between tubulin dimers and microtubules in the modulation of Gq signaling. J. Biol. Chem., 278, 34299-34308, 2003.

15) Popova, J.S. and RASENICK, M.M. Clathrin-mediated endocytosis of m3 muscarinic receptors. Roles for Gbetagamma and tubulin J. Biol.Chem., 279 30410-30418, 2004.

16) Allen, J, Yu, J-Z, Donati, R.J. and RASENICK, M.M. Beta Adrenergic Receptor Stimulation Promotes Galpha s Internalization Through Lipid Rafts: A Study in Living Cells Mol. Pharmacol 67-1493-1504, 2005

17) Yu, J-Z and RASENICK, M.M. Tau associates with actin in differentiating PC12 cells. FASEB J.. 20: 1-10, 2006.

18) Allen J, Halvorsen R, and RASENICK MM Lipid Raft Microdomains and Neurotransmitter Signaling. NATURE Reviews Neuroscience 8:128-140, 2007.

19) Donati, RJ, Dwivedi, Y., Roberts, RC, Conley, RR, Pandey, GN and RASENICK, MM. Post-mortem Brain Tissue of Depressed Suicides Reveals Increased Gs Localization in Lipid Raft Domains Where it is Less Likely to Activate Adenylyl Cyclase.  J. Neuroscience 28:3042-3050, 2008

20) Layden, BT, Saengsawang, W, Donati, RJ, Yang, S, Mulhearn, DC, Johnson, ME and RASENICK MM, Structural model of a complex between the heterotrimeric G protein, Gs + and tubulin. Biochemica et Biophysica Acta-Molecular Cell Research 1783:964-973, 2008


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