835 S. Wolcott Ave., (M/C 901)
Chicago, IL 60612-7342
312-996-7620 phone
312-996-1414 fax
Carlos Stocco, PhD
Associate Professor
Molecular Pathways Controlling Ovarian Gene Expression
Our research interest, in a broad sense, is to understand the mechanisms controlling gene expression in the ovary. The ovarian cycle involves sequential structural and functional changes such as follicle initiation, growth, selection, ovulation, luteinization, and atresia. Transition between each stage depends on the activation or repression of specific genes. By studying how gene activation and repression are controlled, we hope to better understand the development, physiology, and pathology of the mammalian ovary. Currently, we are studying the mechanisms via which GATA transcription factors regulate ovarian function. We are also investigating the mechanisms controlling the expression of aromatase, an enzyme involved in the synthesis of estradiol. Estradiol is crucial for female and male fertility, normal development, and central nervous and skeletal system function, but also promotes the growth of breast, endometrial, and ovarian tumors. Our research will provide useful insights into the etiology as well as for the development of methods to improve detection and treatment of human diseases in which GATA factors and estradiol are involved.