Tatyana A. Voyno-Yasenetskaya, MD, PhD

Professor of Pharmacology
Center for Lung and Vascular Biology

My laboratory is interested in heterotrimeric G proteins, a family of signaling proteins that transduce messages from receptors for extracellular stimuli into cellular responses mediated by effector enzymes or ion channels. To understand G protein signaling and its biological functions, it is necessary to identify effectors that are activated through physical interaction with a G{alpha} or G{beta}{gamma} subunits. As endothelial cells are an important component of vascular tissue, studying protein interactions in this cell type will not only provide insights into endothelial cell biochemistry, but may also provide insights into disease conditions, such as vascular disease. We have developed the program for systemic identification and characterization of the proteins that interact with {alpha} subunits of heterotrimeric G12 and G13 proteins in human vascular endothelial cells.

4135 CoMRB
909 S. Wolcott Ave.
(312) 996-9823
tvy@uic.edu

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