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Home > Faculty Research>Jalees Rehman, MD

 

Primary Faculty

Jalees Rehman, MD

Associate Professor of Medicine,
Section of Cardiology, and Pharmacology

rehman
My research laboratory is currently studying the biology of regenerative stem and progenitor cells in the cardiovascular system. We have a number of active research projects in the lab, such as investigating the role of mitochondrial metabolism and reactive oxygen species (ROS) as regulators of stem cell differentiation, the maturation and senescence of endothelial progenitor cells, studying the role of mitochondrial networks in cell proliferation and the angiogenic potential of adult mesenchymal stem cells.

4113 COMRB
909 S. Wolcott Ave.
(312) 996-5552
jalees@uic.edu

Lab home page

 

Selected Publications

Rehman J, Li J, Orschell CM, March KL. Endothelial Progenitor Cells are Derived From Monocyte/Macrophages and Secrete Angiogenic Growth Factors. Circulation 107:1164-1169, 2003.

Rehman J, Traktuev D, Li JL, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, Pell CL, Johnstone BH, Considine RV, March KL. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation, 109(10): 1292-1298, 2004.

Rehman J, Li J, Parvathaneni L, Karlsson G, Panchal VR, Temm-Grove CJ, Mahenthiran J, March KL. Exercise Acutely Increases Circulating Endothelial Progenitor Cells and Monocyte/Macrophage Derived Angiogenic Cells. Journal of the American College of Cardiology, 43: 2314-8, 2004.

Opitz CA, Rimmerman N, Zhang Y, Mead LE, Yoder MC, Ingram DA, Rehman J. Endothelial Progenitor Cells Release the Endocannabinoids Anandamide and 2-Arachidonoylglycerol. FEBS Letters, 581(25): 4927-31, 2007.
  
Rehman J. An inconvenient truth: recognizing individual differences in arteriogenesis. Circulation Research 102(10): 1146-1147, 2008.

Zhang Y, Herbert BS, Rajashekhar G, Ingram DA, Yoder MC, Clauss M, Rehman J.
Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-alpha via the p38 mitogen-activated protein kinase pathway.
FASEB J. 2009 May;23(5):1358-65.

Zhao YD, Ohkawara H, Rehman J, Wary KK, Vogel SM, Minshall RD, Zhao YY, Malik AB. Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1 and Cdc42 signaling.
Circulation Research 2009 Sep 25;105(7):696-704

Zhang Y, Ingram DA, Murphy MP, Saadatzadeh MR, Mead LE, Prater DN, Rehman J.  Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1675-82.

Hofmann Bowman M, Wilk J, Heydemann A, Kim G, Rehman J, Lodato JA, Raman J, McNally EM. S100A12 mediates aortic wall remodeling and aortic aneurysm. Circulation Research. 2010 Jan 8;106(1):145-54.

Rehman J. Feeling the elephant of cardiovascular cell therapy. Circulation. 2010 Jan 19;121(2):197-9.

Archer SL, Marsboom G, Kim GH, Zhang HJ, Toth PT, Svensson EC, Dyck JR, Gomberg-Maitland M, Thébaud B, Husain AN, Cipriani N, Rehman J. Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.
Circulation. 2010 Jun 22;121(24):2661-71.

Rehman J. Empowering self-renewal and differentiation: the role of mitochondria in stem cells. J Mol Med. 2010 Oct 88(10):981-6.

Thenappan T, Goel A, Marsboom G, Fang YH, Toth PT, Zhang HJ, Kajimoto H, Hong Z, Paul J, Wietholt C, Pogoriler J, Piao L, Rehman J, Archer SL. A central role for CD68(+) macrophages in hepatopulmonary syndrome: reversal by macrophage depletion. Am J Respir Crit Care Med. 2011 Apr 15;183(8):1080-91.

 

 

 

 

 

 

 

 

 
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