UIC Department of Pharmacology: Faculty Research

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Primary Faculty

John P. O'Bryan, PhD
Associate Professor of Pharmacology
The temporal and spatial regulation of signal transduction pathways is paramount to the normal growth, development and homeostatic regulation of an organism. Disruption of these regulatory pathways has profound consequences, underlying many pathological conditions including neurodegeneration, cancer and cardiovascular disease. The research in our lab is aimed at understanding the role of scaffolding proteins in coordinating signal transduction pathways. This class of molecules consists predominantly of protein:protein interaction domains and functions to assemble multi-protein complexes that regulate cellular biochemical pathways. The current focus is on the unique, multi-domain scaffold intersectin (ITSN), which coordinates the processes of endocytosis and signal transduction and thus contributes to cell growth, differentiation, and survival.
Research Funding: NIH, DOD, St. Baldrick's Foundation, Foundation Jerome Lejeune 4091 CoMRB 909 S. Wolcott Ave. (312) 996-6221 obryanj@uic.edu Lab home page Publications