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Primary Faculty
- Athar H. Chishti, PhD
Professor
- Oscar Colamonici, MD
Associate Professor
- Xiaoping Du, MD, PhD
Professor
- Tohru Fukai, MD, PhD
Associate Professor
- Thomas M. Guenthner, PhD
Professor
- Tohru Kozasa, MD, PhD
Associate Professor
- Stephen C.-T. Lam, PhD
Associate Professor
- Guy C. Le Breton, PhD
Professor
- Asrar B. Malik, PhD
Distinguished Professor and Department Head
- Dolly Mehta, PhD
Assistant Professor
- Richard D. Minshall, PhD
Associate Professor
- Shigehiro Nakajima, MD, PhD
Professor
- John P. O'Bryan, PhD
Assistant Professor
- Miodrag Radulovacki, MD, PhD
Professor
- Randal A. Skidgel, PhD
Professor
- Karen Snapp, PhD
Assistant Professor
- Chinnaswamy Tiruppathi, PhD
Associate Professor
- Masuko Ushio-Fukai, PhD
Associate Professor
- Tatyana Voyno-Yasenetskaya MD, PhD
Professor
- Kishore K. Wary, PhD
Assistant Professor
- Richard D. Ye, MD, PhD
Professor
- You-Yang Zhao, PhD
Assistant Professor
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Tohru Kozasa, MD, PhD
 Associate Professor of Pharmacology
We are investigating the biochemical mechanism
and physiological function of G protein-mediated signal transduction
pathways. The major goal is to understand the regulatory mechanism
of activation of Rho family GTPases by heterotrimeric G proteins.
Rho family GTPases are involved in a variety of cellular functions
by controlling the organization of actin cytoskeleton or gene expression.
We have demonstrated that G{alpha}12 and G{alpha}13 interact with
and regulate the activity of a novel Rho specific GEF (guanine nucleotide
exchange factor), p115RhoGEF. We are characterizing the regulation
and physiological function of G12/G13-mediated signaling pathway
in detail using reconstitution of purified components, cultured
cell lines, and C. elegans as model animal system.
4111 CoMRB
909 S. Wolcott Ave.
(312) 413-0111
TKozas@uic.edu
Lab home page
Publications
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