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Home > Faculty Research >Jason X.-J. Yuan, MD, PhD >Publications

Selected Publications

A.  Books

  1. Yuan, J.X.-J. (ed) Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms. Kluwer Academic Publishers, Boston, MA, 2004 (608 pages). ISBN: 978-1-4020-7857-6
  2. Yuan, J.X.-J. (ed) Ion Channels in the Pulmonary Vasculature. Taylor & Francis Group, Boca Raton, FL, 2005 (832 pages). ISBN-13:978-0-8247-5968-1
  3. Yuan, J.X.-J. and Jeremy P.T. Ward (eds) Membrane Receptors, Channels, and Transporters in Pulmonary Circulation. Humana Press-Springer, New York, NY, 2010 (501 pages). ISBN:978-1-60761-499-9
  4. Yuan, J.X.-J., J.G.N. Garcia, C.A. Hales, S. Rich, S.L. Archer, and J.B. West (eds) Textbook of Pulmonary Vascular Disease. Springer, New York, NY. 2011 (1658 pages, 590 illus., 245 in color). ISBN:978-0-387-87428-9

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B.  Peer-Reviewed Original Research Articles

  1. Yuan, X.-J., M.L. Tod, L.J. Rubin and M.P. Blaustein.  Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries.  Am. J. Physiol.  259:H281-H289, 1990.
  2. Bova, S., W.F. Goldman, X.-J. Yuan and M.P. Blaustein.  Influence of Na+ gradient on Ca2+ transients and contraction in vascular smooth muscle.  Am. J. Physiol. 259:H409-H423, 1990.
  3. Yuan, X.-J., W.F. Goldman, M.L. Tod, L.J. Rubin and M.P. Blaustein.  Ionic currents in rat pulmonary and mesenteric arterial myocytes in primary culture and subculture.  Am. J. Physiol.  264:L107-L115, 1993.
  4. Yuan, X.-J., W.F. Goldman, M.L. Tod, L.J. Rubin and M.P. Blaustein.  Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes.  Am. J. Physiol.  264:L116-L123, 1993. ("The 50 Most-Frequently-Cited Articles" in Am J Physiol Lung Cell Mol Physiol: No. 7 as of 02/02/2005 to 10/17/2005; No. 9 as of April 1, 2009)
  5. Yuan, X.-J., M.L. Tod, L.J. Rubin and M.P. Blaustein.  Deoxyglucose and reduced glutathione mimic the effects of hypoxia on K+ and Ca2+ conductances in pulmonary artery cells.  Am. J. Physiol. 267:L52-L63, 1994.
  6. Yuan, X.-J., M.L. Tod, L.J. Rubin and M.P. Blaustein.  Inhibition of cytochrome P-450 reduces voltage-gated K+ currents in pulmonary arterial myocytes. Am. J. Physiol. 268:C259-C270, 1995.
  7. Bright, R.T., C.G. Salvaterra, L.J. Rubin and X.-J. Yuan. Inhibition of glycolysis by 2-DOG increases [Ca2+]i in pulmonary arterial smooth muscle cells. Am. J. Physiol. 269:L203-L208, 1995.
  8. Yuan, X.-J., M.L. Tod, L.J. Rubin and M.P. Blaustein. Hypoxic and metabolic regulation of voltage-gated K+ channels in pulmonary artery smooth muscle cells. Exp. Physiol. 80:803-813, 1995.
  9. Yuan, X.-J.  Voltage-gated K+ Currents regulate resting membrane potential and [Ca2+]i in pulmonary artery myocytes.  Circ. Res. 77:370-378, 1995.
  10. Yuan, X.-J., T. Sugiyama, W.F. Goldman, L.J. Rubin and M.P. Blaustein. A mitochondrial uncoupler increases KCa currents but decreases KV currents in pulmonary artery myocytes.  Am. J. Physiol. 270:C321-C331, 1996.
  11. Yuan, X.-J., M.L. Tod, L.J. Rubin and M.P. Blaustein.  NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels.  Proc. Natl. Acad. Sci. USA 93:10489-10494, 1996.
  12. Zhao, Y., M.L. Tod, L.J. Rubin and X.-J. Yuan.  Pulmonary vasoconstrictor effects of prostacyclin in rats: Potential role of thromboxane receptors.  J. Appl. Physiol. 81(6):2595-2603, 1996.
  13. Yuan, X.-J., R.T. Bright, A.M. Aldinger, L.J. Rubin.  Nitric oxide inhibits serotonin-induced calcium release in pulmonary artery smooth muscle cells. Am. J. Physiol. 272:L44-L50, 1997.
  14. Zhao, Y., J. Wang, L.J. Rubin and X.-J. Yuan. Inhibition of KV and KCa channels antagonizes NO-induced relaxation in pulmonary artery. Am. J. Physiol. 272:H904-H912, 1997.
  15. Yuan, X.-J.  Role of calcium-activated chloride current in regulating pulmonary vasomotor tone.  Am. J. Physiol. 272:L959-L968, 1997.
  16. Wang, J., M. Juhaszova, L.J. Rubin, and X.-J. Yuan. Hypoxia inhibits gene expression of voltage-gated K+ channel a-subunits in pulmonary artery smooth muscle cells.  J. Clin.  Invest. 100(9): 2347-2353, 1997.
  17. Zhao, Y., J. Wang, L.J. Rubin, and X.-J. Yuan.  Roles of K+ and Cl- channels in cAMP-induced pulmonary vasodilation.  Exp. Lung Res. 24:71-83, 1998.
  18. Yuan, X.-J., J. Wang, M. Juhaszova, V.A. Golovina, and L.J. Rubin. Molecular basis and function of voltage-gated K+ channels in pulmonary arterial smooth muscle cells.  Am. J. Physiol.  274:L621-L635, 1998.
  19. Yuan, X.-J., J. Wang, M. Juhaszova, S.P. Gaine, and L.J. Rubin.  Attenuated K+ channel gene transcription in primary pulmonary hypertension. Lancet.  351(9104):726-727, 1998.
  20. Yuan, J.X.-J., A.M. Aldinger, M. Juhaszova, J. Wang, J.V. Conte, S.P. Gaine, J.B. Orens, and L.J. Rubin. Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension. Circulation. 98:1400-1406, 1998.
  21. Wang, J., M. Juhaszova, J.V. Conte, Jr., S.P. Gaine, L.J. Rubin, and J.X.-J. Yuan. Action of fenfluramine on voltage-gated K+ channels in human pulmonary-artery smooth-muscle cells. Lancet.  352(9124):290, 1998.
  22. Seiden, J.E., O. Platoshyn, A.E. Bakst, S.S. McDaniel, and J.X.-J. Yuan. High K+-induced membrane depolarization attenuates endothelium-dependent pulmonary vasodilation. Am. J. Physiol. Lung Cell. Mol. Physiol. 278:L261-L267, 2000.
  23. Wang, J.-Y., J. Wang, V.A. Golovina, L. Li, O. Platoshyn, and J.X.-J. Yuan. Role of K+ channel expression in polyamine-dependent intestinal epithelial cell migration. Am.J. Physiol.Cell Physiol. 278:C303-C314, 2000.
  24. Platoshyn, O., V.A. Golovina, C.L. Bailey, A. Limsuwan, S. Krick, M. Juhaszova, J.E. Seiden, L.J. Rubin, and J.X.-J. Yuan.  Sustained membrane depolarization and pulmonary artery smooth muscle cell proliferation. Am. J. Physiol. Cell Physiol. 279:C1540-C1549, 2000.
  25. Golovina, V.A., O. Platoshyn, C.L. Bailey, J. Wang, A. Limsuwan, M. Sweeney, L.J. Rubin, and J.X.-J. Yuan.  Upregulated TRP and enhanced capacitative Ca2+ entry in human pulmonary artery myocytes during proliferation. Am. J. Physiol. Heart Circ. Physiol. 280:H746-H755, 2001. ("The 50 Most-Frequently-Cited Articles" in Am J Physiol Heart Circ: No. 16 as of April, 2009)
  26. McDaniel, S.S., O. Platoshyn, J. Wang, Y. Yu, M. Sweeney, S. Krick, L.J. Rubin, and J.X.-J. Yuan. Capacitative Ca2+ entry in agonist-induced pulmonary vasoconstriction. Am.J. Physiol. Lung Cell. Mol. Physiol. 280:L870-L880, 2001. ("The 50 Most-Frequently-Cited Articles" in Am J Physiol Lung Cell Mol Physiol: No. 32 as of August 27, 2008; No. 33 as of April 1, 2009) (With an Editorial by Stevens T, Is there a role for store-operated calcium entry in vasoconstriction. Am.J. Physiol. Lung Cell. Mol. Physiol. 280:L866-L869, 2001)
  27. Platoshyn, O., Y. Yu, V.A. Golovina, S.S. McDaniel, S. Krick, L. Li, J.-Y. Wang, L.J. Rubin, and J.X.-J. Yuan.  Chronic hypoxia decreases Kv channel expression and function in pulmonary artery myocytes.  Am. J. Physiol. Lung Cell. Mol. Physiol. 280:L801-L812, 2001.
  28. Krick, S., O. Platoshyn, M. Sweeney, H. Kim, and J.X.-J. Yuan.  Activation of K+ channels induces apoptosis in vascular smooth muscle cells.  Am.J. Physiol. Cell Physiol. 280: C970-C979, 2001.
  29. Rao, J.N., L.Li, V.A. Golovina, O. Platoshyn, E.D. Strauch, J.X.-J. Yuan, and J.-Y. Wang.  Ca2+-RhoA signaling pathway required for polyamine-dependent intestinal epithelial cell migration.  Am. J. Physiol. Cell Physiol. 280:C993-C1007, 2001.
  30. Ekhterae, D., O. Platoshyn, S. Krick, Y. Yu, S.S. McDaniel, and J.X.-J. Yuan.  Bcl-2 decreases voltage-gated K+ channel activity and enhances survival in vascular smooth muscle cells.  Am. J.  Physiol. Cell Physiol. 281:C157-C178, 2001.
  31. Limsuwan, A., O. Platoshyn, Y. Yu, L.J. Rubin, A. Rothman, and J.X.-J. Yuan.  Inhibition of K+ channel activity in pulmonary artery smooth muscle cells by serum from the patients with pulmonary hypertension secondary to congenital heart diseases.  Pediatr. Res. 50:23-28, 2001.
  32. Krick, S., O. Platoshyn, S.S. McDaniel, L.J. Rubin, and J.X.-J. Yuan.  Augmented K+ currents and mitochondrial membrane depolarization in pulmonary artery myocyte apoptosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 281:L887-L894, 2001.
  33. McDaniel, S.S., O. Platoshyn, Y. Yu, M. Sweeney, V.A. Miriel, V.A. Golovina, S. Krick, Lapp BR, J.-Y. Wang, and J.X.-J. Yuan.  Anorexic effect of K+ channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells.  J. Appl. Physiol. 91:2322-2333, 2001.
  34. Yu, Y., O. Platoshyn, J. Zhang, S. Krick, Y. Zhao, L. J. Rubin, A. Rothman, and J.X.-J. Yuan. c-Jun decreases voltage-gated K+ channel activity in pulmonary artery smooth muscle cells.  Circulation 104:1557-1563, 2001.
  35. Krick, S., O. Platoshyn, M. Sweeney, S.S. McDaniel, S. Zhang, L.J. Rubin, and J.X.-J. Yuan. Nitric oxide induces apoptosis by activating K+ channels in pulmonary vascular smooth muscle cell.  Am. J. Physiol. Heart Circ. Physiol. 282:H184-H193, 2002.
  36. Rao, J.N., O. Platoshyn, L. Li, X. Guo, V.A. Golovina, J.X.-J. Yuan, and J.-Y. Wang.  Activation of K+ channels and increased migration of differentiated intestinal epithelial cells after wounding.  Am. J. Physiol. Cell Physiol. 282:C885-C898, 2002.
  37. Sweeney, M., S.S. McDaniel, O. Platoshyn, S. Zhang, Y. Yu, B.R. Lapp, Y. Zhao, P.A. Thistlethwaite, and J.X.-J. Yuan.  Role of capacitative Ca2+ entry in bronchial contraction and remodeling.  J. Appl. Physiol. 92:1594-1602, 2002.
  38. Sweeney, M., Y. Yu, O. Platoshyn, S. Zhang, S.S. McDaniel, and J.X.-J. Yuan. Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell growth.  Am. J. Physiol. Lung Cell. Mol. Physiol. 283:L144-L155, 2002. ("The 50 Most-Frequently-Cited Articles" in Am J Physiol Lung Cell Mol Physiol: No. 18 as of April 1, 2009)
  39. Platoshyn, O., S. Zhang, S.S. McDaniel, and J.X.-J. Yuan. Cytochrome c activates K+ channels prior to inducing apoptosis.  Am. J. Physiol. Cell Physiol. 283:C1298-C1305, 2002.
  40. Yu, Y., M. Sweeney, S. Zhang, O. Platoshyn, J. Landsberg, A. Rothman, and J.X.-J. Yuan. PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression.  Am. J. Physiol. Cell Physiol. 284:C316-C330, 2003.
  41. Ekhterae, D., O. Platoshyn, S. Zhang, C.V. Remillard, and J.X.-J. Yuan. Apoptosis repressor with caspase domain inhibits cardiomycyte apoptosis by reducing K+ currents. Am. J. Physiol. Cell Physiol. 284:C1405-C1515, 2003.
  42. Du, L., C.C. Sullivan, D. Chu, A.J. Cho, M. Kido, P.L. Wolf, J.X.-J. Yuan, R. Deutsch, S.W. Jamieson, and P.A. Thistlethwaite. Signaling molecules in nonfamilial pulmonary hypertension. N. Engl. J. Med. 348(6):500-509, 2003.
  43. Zhang, S., I. Fantozzi, D.D. Tigno, E.S. Yi, O. Platoshyn, P.A. Thistlethwaite, J.M. Kriett, G. Yung, L.J. Rubin, and J.X.-J. Yuan. Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 285:L740-L754, 2003.
  44. Rao, J.N., X. Guo, L. Liu, T. Zou, K. S. Murthy, J. X.-J. Yuan, and J.-Y. Wang. Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution. Am. J. Physiol. Cell Physiol. 284:C848-C859, 2003.
  45. Fantozzi, I., S. Zhang, O. Platoshyn, C.V. Remillard, R.R. Cowling, and J.X.-J. Yuan.  Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 285:L1233-L1245, 2003.
  46. Platoshyn, O., C.V. Remillard, I. Fantozzi, M. Mandegar, T.T. Sison, S. Zhang, E. Burg, and J.X.-J. Yuan. Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 287:L226-L238, 2004.
  47. Brevnova, E.E., O. Platoshyn, S. Zhang, and J.X.-J. Yuan. Overexpression of human KCNA5 increases IK(V) and enhances apoptosis. Am. J. Physiol. Cell Physiol. 287:C715-C722, 2004.
  48. Yu, Y., I. Fantozzi, C.V. Remillard, J.W. Landsberg, N. Kunichika, O. Platoshyn, D.D. Tigno, P.A. Thistlethwaite, L.J. Rubin, and J.X.-J. Yuan. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc. Natl. Acad. Sci. USA. 101(8):13861-13866, 2004.
  49. Zhang, S., C.V. Remillard, I. Fantozzi, and J.X.-J. Yuan. ATP-induced mitogenesis is mediated by CREB-enhanced TRPC4 expression and activity in human pulmonary artery smooth muscle cells.  Am. J. Physiol. Cell Physiol. 287:C1192-C1201, 2004.
  50. Kunichika, N., Y. Yu, C.V. Remillard, O. Platoshyn, S. Zhang, and J.X.-J. Yuan. Overexpression of TRPC1 enhances pulmonary vasoconstriction induced by capacitative Ca2+ entry. Am. J. Physiol. Lung Cell. Mol. Physiol. 287:L962-L969, 2004.
  51. Kunichika, N, J.W. Landsberg, Y. Yu, H. Kunichika, P.A. Thistlethwaite, L.J. Rubin, and J.X.-J. Yuan. Bosentan inhibits transient receptor potential channels in human pulmonary vascular myocytes. Am. J. Respir. Crit. Care Med. 170:1101-1107, 2004.
  52. Tsigelny, I., M. Hotchko, J.X.-J. Yuan, and S.H. Keller. Identification of molecular determinants that modulate trafficking of F508 CFTR, the mutant ABC transporter associated with cystic fibrosis. Cell Biochem. Biophys. 42(1):41-53, 2005.
  53. Zhang, S., J.X.-J. Yuan, K.E. Barrett, and H. Dong. Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells. Am. J. Physiol. Cell Physiol. 288; C245-C252, 2005.
  54. Laugwitz, K.-L., A. Moretti, J. Lam, P. Gruber, Y. Chen, S. Woodard, L.-Z. Lin, C.-L. Cai, M.M. Lu, M. Reth, O. Platoshyn, J.X.-J. Yuan, S. Evans, and K.R. Chien. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 433:647-653, 2005.
  55. Keller, S.H., O. Platoshyn, and J.X.-J. Yuan. Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways. Cell Biochem. Biophys. 43:365-377, 2005.
  56. Platoshyn, O., I. Fantozzi, C.V. Remillard, T.T. Sison, and J.X.-J. Yuan. Identification of functional voltage-gated Na+ channels in human pulmonary artery smooth muscle cells. Pflügers Arch. - Eur. J. Physiol. 451:380-387, 2005.
  57. Iwata, M., R.T. Cowling, D. Gurantz, C. Moore, S. Zhang, J.X.-J. Yuan, and B.H. Greenberg. Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects. Am. J. Physiol. Heart Circ. Physiol. 289:H2356-H2363, 2005.
  58. Fantozzi, I., W. Huang, J. Zhang, S. Zhang, O. Platoshyn, C.V. Remillard, P.A. Thistelthwaite, and J.X.-J. Yuan. Divergent effects of BMP-2 on gene expression in pulmonary artery smooth muscle cells from normal subjects and patients with pulmonary arterial hypertension. Exp. Lung Res. 31(8):783-806, 2005.
  59. Mauban, J.R.H., K. Wilkinson, C. Schach, and J.X.-J. Yuan. Histamine-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. Am. J. Physiol. Cell Physiol. 290:C325-C336, 2006.
  60. Platoshyn, O., E.E. Brevnova, E.D. Burg, Y. Yu, C.V. Remillard, and J.X.-J. Yuan. Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. Am. J. Physiol. Cell Physiol. 290: C907-C916, 2006.
  61. Rao, J.N., O. Platoshyn, V.A. Golovina, L. Liu, T. Zou, B.S. Marasa, D.J. Turner, J.X.-J. Yuan, and J.-Y. Wang. TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding. Am. J. Physiol. Gastrointest. Liver Physiol. 290:G782-G792, 2006.
  62. Fantozzi, I., O. Platoshyn, A.H. Wong, O. V. Petrauskene, S. Zhang, C.V. Remillard, M.R. Furtado, and J.X.-J. Yuan. Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 291:L994-L1004, 2006.
  63. Tsigelny, I.F., P. Bar-On, Y. Sharikov, L. Crews, M. Hashimoto, M.A. Miller, S.H. Keller, O. Platoshyn, J.X.-J. Yuan, and E. Masliah. Dynamics of α-synuclein aggregation and inhibition of pore-like oligomer development by β-synuclein. FEBS J. 274(7):1862-1877, 2007.
  64. Murray, F., H.H. Patel, R.Y. Suda, S. Zhang, P.A. Thistlethwaite, J.X.-J. Yuan, and P.A. Insel. Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: Role for PDE1. Am. J. Physiol. Lung Cell. Mol. Physiol. 292(1):L294-L303, 2007.
  65. Schach, C., M. Xu, O. Platoshyn, S.H. Keller, and J.X.-J. Yuan. Thiol oxidation causes pulmonary vasodilation by activating K+ channels and inhibiting store-operated Ca2+ channels. Am. J. Physiol. Lung Cell. Mol. Physiol. 292(3):L685-L698, 2007.
  66. Zhang, S., H.H. Patel, F. Murray, C.V. Remillard, C. Schach, P.A. Thistlethwaite, P.A. Insel, and J.X.-J. Yuan. Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effect on TRPC expression and capacitative Ca2+ entry. Am. J. Physiol. Lung Cell. Mol. Physiol. 292(5):L1202-L1210, 2007.
  67. Zhang, S., H. Dong, L.J. Rubin, and J.X.-J. Yuan. Upregulation of Na+/Ca2+ exchanger contributes to the enhanced Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Am. J. Physiol. Cell Physiol. 292(6):C2297-C2305, 2007.
  68. Remillard, C.V., D.D. Tigno, O. Platoshyn, E.D. Burg, E.E. Brevnova, D. Conger, A. Nicholson, B.K. Rana, R.N. Channick, L.J. Rubin, D.T. O'Connor, and J.X.-J. Yuan. Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 292(5):C1837-C1853, 2007.
  69. Patel, H.H., S. Zhang, F. Murray, R.Y.S. Suda, B.P. Head, J.S. Swaney, I.R. Niesman, R.T. Schermuly, S. Pullamsetti, P.A. Thistlethwaite, A. Miyanohara, M.G. Farquhar, J.X.-J. Yuan, and P.A. Insel. Increased smooth muscle caveolin-1 and caveolae expression contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J. 21:2970-2979, 2007.
  70. Yu, Y.I., O. Platoshyn, O. Safrina, I. Tsigelny, J.X.-J. Yuan, and S.H. Keller. Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI). Biol. Cell. 99(8):433-444, 2007.
  71. Platoshyn, O., Y. Yu, C.V. Remillard, and J.X.-J. Yuan. Heterogeneity of acute hypoxia-induced decrease in IK(V) and increase in [Ca2+]cyt in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 293(2):L402-L416, 2007.
  72. Ko, E.A., E.D. Burg, O. Platoshyn, J. Msefya, A.L. Firth, and J.X.-J. Yuan. Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells. Am. J. Physiol. Cell Physiol. 293:C928-C937, 2007.
  73. Wu, W., O. Platoshyn, A.L. Firth, and J.X.-J. Yuan. Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 293(4):L952-L959, 2007.
  74. Tang, T., M.H. Gao, N.C. Lai, A.L. Firth, T. Takahashi, T. Guo, J.X.-J. Yuan, D.M. Roth, and H.K. Hammond. Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation. 117:61-69, 2008.
  75. Xu, M., O. Platoshyn, A. Makino, W.H. Dillmann, K. Akassoglou, C.V. Remillard, and J.X.-J. Yuan. Characterization of agonist-induced vasoconstriction in mouse pulmonary artery. Am. J. Physiol. Heart Circ. Physiol. 294:H220-H228, 2008.
  76. Schach, C., A.L. Firth, M. Xu, C.V. Remillard, H.H. Patel, P.A. Insel, and J.X.-J. Yuan. Regulation of pulmonary vasoconstriction by agonists and caveolae. Exp. Lung Res. 34:195-208, 2008.
  77. Remillard, C.V. and J.X.-J. Yuan. Characterization of hemodynamics in patients with idiopathic and thromboembolic pulmonary hypertension. Clin Med Circ Respir Pul Med. 2:59-68, 2008.
  78. Makino, A. O. Platoshyn, J. Suarez, J.X.-J. Yuan, and W.H. Dillmann. Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice. Am. J. Physiol. Cell Physiol. 295:C221-C230, 2008.
  79. Xu, M., B. Sachs, C.V. Remillard, A. Makino, W.H. Dillmann, K. Akassoglou, and J.X.-J. Yuan. p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction. Am. J. Physiol. Heart Circ. Physiol. 295:H1529-H1538, 2008.
  80. Ogawa, A., A.L. Firth, W. Yao, L.J. Rubin, and J.X.-J. Yuan. Prednisolone inhibits PDGF-induced nuclear translocation of NF-κB in human pulmonary artery smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 295:L648-L657, 2008.
  81. Tsigelny, I.F., L. Crews, G.M. Shaked, Y. Sharikov, H. Mizuno, B. Spencer, E. Rockenstein, M. Trejo, O. Platoshyn, J.X.-J. Yuan, and E. Masliah. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer’s and Parkinson’s diseases. PloS ONE. 3(9):e3135, 2008.
  82. Sacks, R.S., A.L. Firth, C.V. Remillard, N. Agange, J. Yau, E.A. Ko, and J.X.-J. Yuan. Thrombin-induced increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 295:L1048-L1055, 2008.
  83. Rao, J.N., S.V. Liu, T. Zou, L. Liu, L. Xiao, X.. Zhang, E. Bellavance, J.X.-J. Yuan, and J.-Y. Wang. Rac1 promotes intestinal epithelial restitution by increasing Ca2+ influx through interaction with phospholipase C-γ1 after wounding. Am. J. Physiol. Cell Physiol. 295:C1499-C1509, 2008.
  84. Yu, Y., S.H. Keller, C.V. Remillard, O. Safrina, A. Nicholson, S.L. Zhang, W. Jiang, N. Vangala, J.W. Landsberg, J.-Y. Wang, P.A. Thistlethwaite, R.N. Channick, I.M. Robbins, J.E. Loyd, H.A. Ghofrani, F. Grimminger, R.T. Schermuly, M.D. Cahalan, L.J. Rubin, and J.X.-J. Yuan. A functional single nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation 119:2313-2322, 2009. (With an Editorial by Hamid R and Newman JH, Evidence for inflammatory signaling in idiopathic pulmonary artery hypertension: TRPC6 and Nuclear Factor-kB. Circulation 119:2297-2298, 2009).
  85. Yao, W., A.L. Firth, R.S. Sacks, A. Ogawa, W.R. Auger, P.F. Fedullo, M.M. Madani, N. Sakakibara, G.Y. Lin, P.A. Thistlethwaite, S.W. Jamieson, L.J. Rubin and J.X.-J. Yuan. Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 296:L870-L878, 2009. (With an Editorial Focus by Majka S and Alvares DF. Neovascular capacity of endothelial progenitor cells in the adult pulmonary circulation. Am. J. Physiol. Lung Cell. Mol. Physiol. 296: L868-L869, 2009)
  86. Firth, A.L., J. Yau, A. White, P.G. Childs, J.J. Marsh, T.A. Morris, and J.X.-J. Yuan. Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary artery smooth muscle and endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 296:L979-L986, 2009.
  87. Zhao, Y.-Y., Y.D. Zhao, M.K. Mirza, J.H. Huang, H.-H.S.K. Potula, S.M. Vogel, V. Brovkovych, J.X.-J. Yuan, J. Wharton, and A.B. Malik.  Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. J. Clin. Invest. 119:2009-2018, 2009.
  88. Li, X., X. Zhang, R. Leathers, A. Makino, C. Huang, P. Parsa, J. Macias, J.X.-J. Yuan, S.W. Jamieson, and P.A. Thistlethwaite. Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat. Med. 15(11):1289-1297, 2009.
  89. Ogawa, A., A.L. Firth, W. Yao, M.M. Madani, K.M. Kerr, W.R. Auger, S.W. Jamieson, L.J. Rubin, P.A. Thistlethwaite, and J.X.-J. Yuan. Inhibition of mTOR attenuates store-operated Ca2+ entry in cells isolated from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 297:L666-L676, 2009.
  90. Burg, E.D., O. Platoshyn, I.F. Tsigelny, B. Lozano-Ruiz, B.K. Rana and J.X.-J. Yuan. Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns. Am. J. Physiol. Cell Physiol. 298:C496-C509, 2010.
  91. Firth, A.L., W. Yao, C.V. Remillard, A. Ogawa, and J.X.-J. Yuan. Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 298:L548-L557, 2010.
  92. Firth, A.L., W. Yao, A. Ogawa, M.M. Madani, G.L. Lin, and J.X.-J. Yuan. Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension. Am. J. Physiol. Cell Physiol. 298:C1217-C1225, 2010.
  93. Kuang, T, J. Wang, B. Pang, X. Huang, E.D. Burg, J.X.-J. Yuan, and C. Wang C. Combination of sildenafil and simvastatin ameliorates monocrotaline-induced pulmonary hypertension in rats. Pulm. Pharmacol. Ther. 23:456-464, 2010.
  94. Gao, M.H., T. Tang, N.C. Lai, A. Miyanohara, T. Guo, R. Tang, A.L. Firth, J.X.-J. Yuan, and H.K. Hammond. Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant. Mole. Pharmacol. 79(3);381-388, 2011.
  95. Sugano, Y., N.C. Lai, M.H. Gao, A.L. Firth, J.X.-J. Yuan, W.Y.W. Lew, and H.K. Hammond. Activated expression of cardiac adenylyl cyclise 6 reduces dilation and dysfunction of the pressure-overloaded heart. Biochem. Biophys. Res. Commun. 405(3):349-355, 2011.
  96. Song, M.Y., A. Makino, and J.X.-J. Yuan. STIM2 contributes to enhanced store-operated Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Pulm. Circ. 1(1):84-94, 2011.
  97. Kuang, T., J. Wang, A. Zeifman, B Pang, X. Huang, E.D. Burg, J.X.-J. Yuan, and C. Wang. Combination use of sildenafil and simvastatin increases BMPR-II signal transduction in rats with monocrotaline-mediated pulmonary hypertension. Pulm. Circ. 1:116-119, 2011.
  98. Tang, T., H.K. Hammond, A.L. Firth, Y. Yang, M.H. Gao, J.X.-J. Yuan, N.C. Lai. Adenylyl cyclase 6 improves calcium uptake and left ventricular function in aged hearts. J. Am. Coll. Cardiol. 57(18):1846-1855, 2011

 

C. Invited Articles, Review Articles, and Editorials

  1. Sweeney, M. and J.X.-J. Yuan. Hypoxic pulmonary vasoconstriction: Role of voltage-gated potassium channels.  Respir. Res. 1:40-48, 2000. (Review Article)
  2. Yuan, J.X.-J.  Oxygen-sensitive K+ channel(s): where and what?  Am. J. Physiol. Lung Cell. Mol. Physiol. 281:L1345-L1349, 2001. (Editorial Focus)
  3. Mandegar, M. and J.X.-J. Yuan. Role of K+ channels in pulmonary hypertension.  Vasc. Pharmacol.  38(1):25-33, 2002. (Review Article)
  4. Mandegar, M. C.V. Remillard, and J.X.-J. Yuan. Ion channels in pulmonary arterial hypertension. Prog. Cardiovas. Dis. 45(2):81-114, 2002. (Review Article)
  5. Remillard, C.V. and J.X.-J. Yuan. Activation of K+ channels: an essential pathway in programmed cell death. Am. J. Physiol. Lung Cell. Mol. Physiol. 286(1):L49-L67, 2004. (Review Article)
  6. Landsberg, J.W. and J.X.-J. Yuan. Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation. NIPS (News in Physiological Sciences) 19:44-50, 2004. (Review Article)
  7. Mandegar, M., P.A. Thistlethwaite, and J.X.-J. Yuan. Molecular biology of primary pulmonary hypertension. Cardiol. Clin. 22(3):417-429, 2004. (Review Article)
  8. Mandegar, M., Y.-C.B. Fung, W. Huang, C.V. Remillard, L.J. Rubin, and J.X.-J. Yuan. Cellular and molecular mechanisms of pulmonary vascular remodeling: Role in the development of pulmonary hypertension.  Microvasc. Res. 68(2):75-103, 2004. (Review Article)
  9. Mauban J.R.H., C.V. Remillard, and J.X.-J. Yuan. Hypoxic pulmonary vasoconstriction: role of ion channels. J. Appl. Physiol. 98:415-420, 2005. (Review Article)
  10. Yuan, J.X-J. and L.J. Rubin. Pathogenesis of pulmonary arterial hypertension: The need for multiple hits. Circulation. 111:534-538, 2005. (Editorial)
  11. Remillard, C.V. and J.X.-J. Yuan. ClC-3: more than just a volume-sensitive Cl- channel. Br. J. Pharmacol.  145:1-2, 2005. (Editorial)
  12. Remillard, C.V. and J.X.-J. Yuan. PGE2 and PAR-1 in pulmonary fibrosis: a case of biting the hand that feeds you? Am. J. Physiol. Lung Cell. Mol. Physiol. 288:L789-L792, 2005. (Editorial Focus)
  13. Remillard, C.V. and J.X.-J. Yuan. High altitude pulmonary hypertension: Role of K+ and Ca2+ channels. High Altitude Med. Biol. 6(2): 133-146, 2005 (Review Article)
  14. Murray, F., P.A. Insel, and J.X.-J. Yuan. Role of O2-sensitive K+ and Ca2+ channels in the regulation of the pulmonary circulation: Potential role of caveolae and implications for high altitude pulmonary edema. Respir. Physiol. Neurobiol. 151:192-208, 2006. (Review Article)
  15. Burg, E.D., C.V. Remillard, and J.X.-J. Yuan. K+ channels in apoptosis. J. Membr. Biol. 209 (1):3-20, 2006. (Review Article)
  16. Neubauer J, J.K. Brown, B.L.M. Hogan, S.H. Randell, B. Stripp, D.J. Weiss, L. Clerch, P.W. Finn, M.M. Fuster, R. Glenny, L.S. King, M. Kraft, M. Leigh, C. Marsh, J. Metcalf, S. Mette, T. Mertsch, S. Pattee, W. Rom, J. Roman, J.R. Wright, J.X.-J. Yuan, and A. Ofosu. Human embryonic stem cell research. Am. J. Respir. Crit. Care Med. 173:1043-1045, 2006. (Official Statement of the American Thoracic Society)
  17. Remillard, C.V. and J.X.-J. Yuan. TRP channels, CCE and the pulmonary vascular smooth muscle. Microcirculation. 13:671-692, 2006. (Review Article)
  18. Remillard, C.V. and J.X.-J. Yuan. Transient receptor potential channels and caveolin-1: Good friends in tight spaces. Mol. Pharmacol. 70(4): 1151-1154, 2006. (Perspective).
  19. Sacks, R., C.V. Remillard, N. Agange, W.R. Auger, P.A. Thistlethwaite, and J.X.-J. Yuan. Molecular biology of chronic thromboembolic pulmonary hypertension. Sem. Thoracic Cardiovas. Surg. 18(3):265-276, 2006. (Review Article)
  20. Remillard, C.V. and J.X.-J. Yuan. Cardiac L-arginine transport: the CAT is back. J. Physiol. 580(3):699-700, 2007. (Perspective)
  21. Firth A.L., C.V. Remillard, and Yuan, J.X.-J. TRP channels in hypertension. Biochim. Biophy. Acta  1772(8):895-906, 2007 (Review Article)
  22. Yuan, J.X.-J. Point:counterpoint “Release of an endothelium-derived vasoconstrictor and Rho/Rho kinase-mediated calcium sensitization of smooth muscle cell contraction are/are not the main effectors for full and sustained hypoxic pulmonary vasoconstriction. J. Appl. Physiol. 102(5):2078, 2007. (Letter to Editor)
  23. Burg, E.D., C.V. Remillard, and J.X.-J. Yuan. Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis. Br. J. Pharmacol. 153(S1):S99-S111, 2008. (Review Article)
  24. Firth, A.L. and J.X.-J. Yuan. Antagonists of the Kv1.5 potassium channel. Drugs Future. 33(1):31-47, 2008. (Review Article)
  25. Makino, A. and J.X.-J. Yuan. Ambrisentan: A new drug for pulmonary arterial hypertension (Update). In: Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 11th Edition, edited by Brunton LL, Lazo JS, Parker KL, New York, NY: McGraw-Hill, 2008 (online edition) (http://www.accessmedicine.com/updatesContent.aspx?aid=1001187) (Review Article)
  26. Firth, A.L. and J.X.-J. Yuan. Bringing down the ROS: A new therapeutic approach for PPHN. Am. J. Physiol. Lung Cell. Mol. Physiol. 295:L976-L978, 2008. (Editorial Focus)
  27. Hassoun, P.M., L. Mouthon, J.-A. Barbera, S. Eddahibi, S.C. Flores, F. Grimminger, P.L Jones, M. Maitland, E.D. Michelakis, N.W. Morrell, J.H. Newman, M. Rabinovitch, R.T. Schermuly, K.R. Stenmark, N.F. Voelkel, J.X.-J. Yuan, and M. Humbert. Inflammation, growth factors, and pulmonary vascular remodeling. J. Am. Coll. Cardiol. 54:S10-S19, 2009. (Review Article)
  28. Morrell, N.W., S. Adnot, S.L. Archer, J. Dupuis, P.L. Jones, M.R. MacLean, I.F. McMurtry, K.R. Stenmark, P.A. Thistlethwaite, N. Weissman, J.X.-J. Yuan, and E.K. Weir. Cellular and molecular basis of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 54:S20-S31, 2009. (Review Article)
  29. Firth, A.L., O. Platoshyn, E.E. Brevnova, E.D. Burg, F.L. Powell, G.H. Haddad, and J.X.-J. Yuan. Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. Ann. N.Y. Acad. Sci. 1117:101-111, 2009. (Review Article)
  30. Ko, E.A., W.S. Park, A.L. Firth, N. Kim, J.X.-J. Yuan, and J. Han. Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: Modulation by protein kinase. Prog. Biophys. Mol. Biol. 103:95-101, 2010. (Review Article) 
  31. Zhai, Z, J. Wang, L. Zhao, J.X.-J. Yuan, and C. Wang. Pulmonary hypertension in China. Chest. 137:1S-9S, 2010. (Review Article)  
  32. Firth, A.L., J. Mandel and J.X.-J. Yuan. Idiopathic pulmonary arterial hypertension. Dis. Model Mech. 3(5-6): 268-273, 2010. (Review Article)
  33. Song, M.Y., A. Makino, and J.X.-J. Yuan. Role of ROS and redox in regulating the function of TRPC channels. Antioxid. Redox Signal. Apr 11. [Epub ahead of print], 2011. (Review Article)
  34. Firth, A.L., C.V. Remillard, Ol. Platoshyn, I. Fantozzi, E.A. Ko, and J.X.-J. Yuan. Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels. Pulm. Circ. 1:49-72, 2011.
  35. Makino, A., A.L. Firth, and J.X.-J. Yuan. Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling. Compr. Physiol. 1:1-48, 2011.  

 

D.  Book Chapters

  1. Blaustein, M.P., S. Bova, X.-J. Yuan and W.F. Goldman.  The role of sodium/calcium exchange in the regulation of vascular contractility. In "Calcium Transport and Intracellular Homeostasis", edited by Danielle Pansu and Felix Bronner. Springer-Verlag, Berlin: 1990, p. 123-132. (Book Chapter)
  2. Yuan, X.-J., C.G. Salvaterra, M.L. Tod, M. Juhaszova, W.F. Goldman, L.J. Rubin, and M.P. Blaustein.  The sodium gradient, potassium channels, and regulation of calcium in pulmonary and mesenteric arterial smooth muscles: Effects of Hypoxia. In "Ion Flux in Pulmonary Vascular Control", edited by E.K. Weir, J.R. Hume, and J.T. Reeves.  Plenum, New York: 1993, p. 205-222. (Book Chapter)
  3. Yuan, X.-J.  Mechanisms of hypoxic pulmonary vasoconstriction: The role of O2-sensitive voltage-gated K+ channels. In "Oxygen Regulation of Ion Channels and Gene Expression", edited by J. Lopez-Barneo and E.K. Weir. Futura, New York: 1998, p. 207-233. (Book Chapter)
  4. Yuan, J.X.-J. and M.P. Blaustein.  Cellular Potassium Transport.  In “Hypertension Primer: The Essentials of High Blood Pressure”, edited by J.L. Izzo, Jr. and H.R. Black, American Heart Association, Dallas, TX: 1998, p. 56-57. (Book Chapter)
  5. Yuan, J.X.-J. and L.J. Rubin.  Pathophysiology of pulmonary hypertension. In "Respiratory-Circulatory Interactions in Health and Disease", edited by M. Pinsky, S. Scharf, and S. Magder.  Marcel Dekker, Inc., New York, NY: 2001, p. 447-477. (Book Chapter)
  6. Geng, Y.-J. and J.X.-J. Yuan. The relationship of heart and the pathogenesis of hypertension. In "Hypertension", edited by L.S. Liu, L.S. Gong, M.C. Chen, and G.Y. Zeng.  The People Health Publishing House, Beijing: 2001, p.140-156. (Book Chapter)
  7. Yuan, J.X.-J. and L.J. Rubin.  Altered expression and function of Kv channels in primary pulmonary hypertension. In "Potassium Channels in Cardiovascular Biology", edited by S.L. Archer and N.J. Rusch.  Kluwer Academic/Plenum Publishers, New York, NY: 2001, p. 821-836. (Book Chapter)
  8. Yuan, J.X.-J. and M.P. Blaustein.  Cellular Potassium Transport.  In “Hypertension Primer (Third Edition): The Essentials of High Blood Pressure,” edited by J.L. Izzo, Jr. and H.R. Black, American Heart Association, Dallas, TX: 2003, p. 73-75. (Book Chapter)
  9. Patel, H., C.V. Remillard, and J.X.-J. Yuan. Hypoxic regulation of K+ channel expression and function in pulmonary artery smooth muscle cells. In: “Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms,” edited by J.X.-J. Yuan, Kluwer Academic Publishers: Boston, MA, 2004, p. 165-198. (Book Chapter)
  10. Remillard, C.V. and J.X.-J. Yuan. Measurement of ionic currents and intracellular Ca2+ using patch clamp and fluorescence microscopy techniques. In: “Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms,” edited by J.X.-J. Yuan, Kluwer Academic Publishers: Boston, MA, 2004, p. 569-582. (Book Chapter)
  11. Du, L., C.C. Sullivan, D. Chu, A.J. Cho, P.L. Wolf, J.X.-J. Yuan, S.W. Jamieson, and P.A. Thistlethwaite. Signaling molecules in non-familial pulmonary hypertension. Yearbook Rheumatol. 4:154-156, 2004. (Book Chapter)
  12. Remillard, C.V., O. Platoshyn, T. Sison, and J.X.-J. Yuan. Hypoxia-induced modulation of O2-sensitive K+ channels in pulmonary vascular smooth muscle cells. In: “Ion Channels in the Pulmonary Vasculature,” edited by J.X.-J. Yuan, Taylor & Francis: Boca Raton, FL: 2005, p. 379-407. (Book Chapter)
  13. Tigno, D.D., M. Mandegar, C.V. Remillard, and J.X.-J. Yuan. Downregulated Kv channels and upregulated TRPC channels in primary pulmonary hypertension. In: “Ion Channels in the Pulmonary Vasculature,” edited by J.X.-J. Yuan, Taylor & Francis: Boca Raton, FL: 2005, p. 543-566. (Book Chapter)
  14. Zhang, S., C.V. Remillard, O. Platoshyn, and J.X.-J. Yuan. Isolation and culture of pulmonary artery smooth muscle cells. In: “Ion Channels in the Pulmonary Vasculature,” edited by J.X.-J. Yuan, Taylor & Francis: Boca Raton, FL: 2005, p. 605-613. (Book Chapter)
  15. Remillard, C.V. and J.X.-J. Yuan. Measurement of ion channel function using conventional patch-clamp techniques. In: “Ion Channels in the Pulmonary Vasculature,” edited by J.X.-J. Yuan, Taylor & Francis: Boca Raton, FL: 2005, p. 615-633. (Book Chapter)
  16. Yu, Y., O. Platoshyn, and J.X.-J. Yuan. Correlation of ion channel activity with gene expression using single-cell RT-PCR and patch clamp techniques. In: “Ion Channels in the Pulmonary Vasculature,” edited by J.X.-J. Yuan, Taylor & Francis: Boca Raton, FL: 2005, p. 653-663. (Book Chapter)
  17. Keller, S.H., B.H. Parker, and J.X.-J. Yuan. Ion channel trafficking. In: “Ion Channels in the Pulmonary Vasculature,” edited by J.X.-J. Yuan, Taylor & Francis: Boca Raton, FL: 2005, p. 665-685. (Book Chapter)
  18. Brevnova, E.E., B.H. Parker, O. Platoshyn, and J.X.-J. Yuan. Functional study of cloned ion channels in mammalian transfection systems using site-directed mutagenesis. In: “Ion Channels in the Pulmonary Vasculature,” edited by J.X.-J. Yuan, Taylor & Francis: Boca Raton, FL: 2005, p. 687-709. (Book Chapter)
  19. Fantozzi, I., C.V. Remillard, M. Mandegar, and J.X.-J. Yuan. Screening for mRNA expression using polymerase chain reaction. In: “Ion Channels in the Pulmonary Vasculature,” edited by J.X.-J. Yuan, Taylor & Francis: Boca Raton, FL: 2005, p. 711-731 (Book Chapter)
  20. Yuan, J.X.-J. and M.P. Blaustein. Cellular Potassium Transport. In “Hypertension Primer (Fourth Edition): The Essentials of High Blood Pressure,” edited by J.L. Izzo, Jr., D.A. Sica and H.R. Black. American Heart Association and Lippincott Williams & Wilkins: Philadelphia, PA: 2008, pp. 24-26. (Book Chapter)
  21. Yuan, J.X.-J. and L.J. Rubin. Idiopathic and Familial Pulmonary Arterial Hypertension.  In: “Encyclopedia of Molecular Mechanisms of Disease,” edited by F. Lang. Springer Berlin Heidelberg: Germany, 2009; pp. 937-939. (Book Chapter)
  22. Song, M.Y. and J.X.-J. Yuan. Introduction to TRP Channels: structure, function, and regulation. In: “Membrane Receptors, Channels, and Transporters in Pulmonary Circulation,” edited by J.X.-J. Yuan and J.P.T. Ward. Humana Press-Springer: New York, NY: 2010; pp. 99-108. (Adv. Exp. Med. Biol. 661:99-108, 2010). (Book Chapter)
  23. Yuan, J.X.-J. and A. Makino. A Tribute to Dr. Yuan-Cheng B. Fung. In: “Tributes to Yuan-Cheng Fung on his 90th Birthday. Biomechanics: From Molecules to Man,” edited by S. Chien, P.C.-Y. Chen, G.W. Schmid-Schonbein, P. Tong and S.L.-Y. Woo. World Scientific Publishing Co. Pte. Ltd., Hackensack, NJ, 2010, pp. 339-342. (Tribute)
  24. Firth, A.L. and J.X.-J. Yuan. Ion channels and transporters in the pulmonary vasculature. In: “Textbook of Pulmonary Vascular Disease,” edited by J.X.-J. Yuan, J.G.N. Garcia, C.A. Hales, S. Rich, S.L. Archer and J.B. West, Springer: New York, NY; 2011, pp. 221-242. (Book Chapter)
  25. Murray, F., J.X.-J. Yuan and P.A. Insel. Receptor-mediated signal transduction and cell signaling. In: “Textbook of Pulmonary Vascular Disease,” edited by J.X.-J. Yuan, J.G.N. Garcia, C.A. Hales, S. Rich, S.L. Archer and J.B. West, Springer: New York, NY; 2011, pp. 243-270. (Book Chapter)
  26. Remillard, C.V., A. Makino and J.X.-J. Yuan. Isolation and culture of pulmonary vascular smooth muscle and endothelial cells. In: “Textbook of Pulmonary Vascular Disease,” edited by J.X.-J. Yuan, J.G.N. Garcia, C.A. Hales, S. Rich, S.L. Archer and J.B. West, Springer: New York, NY; 2011, pp. 483-492. (Book Chapter)
  27. Remillard, C.V. and J.X.-J. Yuan. Conventional patch clamp techniques and high-throughput patch clamp recordings on a chip for measuring ion channel activity. In: “Textbook of Pulmonary Vascular Disease,” edited by J.X.-J. Yuan, J.G.N. Garcia, C.A. Hales, S. Rich, S.L. Archer and J.B. West, Springer: New York, NY; 2011, pp. 493-508. (Book Chapter)
  28. Murray, F., J.X.-J. Yuan and P.A. Insel. Quantification of DNA, RNA, and protein expression. In: “Textbook of Pulmonary Vascular Disease,” edited by J.X.-J. Yuan, J.G.N. Garcia, C.A. Hales, S. Rich, S.L. Archer and J.B. West, Springer: New York, NY; 2011, pp. 523-536. (Book Chapter)
  29. Breen, E.C. and J.X.-J. Yuan. Gene cloning, transfection and mutagenesis. In: “Textbook of Pulmonary Vascular Disease,” edited by J.X.-J. Yuan, J.G.N. Garcia, C.A. Hales, S. Rich, S.L. Archer and J.B. West, Springer: New York, NY; 2011, pp. 537-554. (Book Chapter)
  30. Yu, Y. and J.X.-J. Yuan. Approaches for manipulation of gene and protein expression. In: “Textbook of Pulmonary Vascular Disease,” edited by J.X.-J. Yuan, J.G.N. Garcia, C.A. Hales, S. Rich, S.L. Archer and J.B. West, Springer: New York, NY; 2011, pp. 555-564. (Book Chapter)
  31. Firth, A.L., W. Yao and J.X.-J. Yuan. Identification of adult stem and progenitor cells in the pulmonary vasculature. In: “Textbook of Pulmonary Vascular Disease,” edited by J.X.-J. Yuan, J.G.N. Garcia, C.A. Hales, S. Rich, S.L. Archer and J.B. West, Springer: New York, NY; 2011, pp. 619-634. (Book Chapter)
  32. Wang, J., D. Zhang, C.V. Remillard and J.X.-J. Yuan. Pathogenic roles of Ca2+ and ion channels and transporters in hypoxia-mediated pulmonary hypertension. In: “Textbook of Pulmonary Vascular Disease,” edited by J.X.-J. Yuan, J.G.N. Garcia, C.A. Hales, S. Rich, S.L. Archer and J.B. West, Springer: New York, NY; 2011, pp. 681-692. (Book Chapter)

 
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