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Primary Faculty
- Athar H. Chishti, PhD
Professor
- Oscar Colamonici, MD
Associate Professor
- Xiaoping Du, MD, PhD
Professor
- Tohru Fukai, MD, PhD
Associate Professor
- Thomas M. Guenthner, PhD
Professor
- Tohru Kozasa, MD, PhD
Associate Professor
- Stephen C.-T. Lam, PhD
Associate Professor
- Guy C. Le Breton, PhD
Professor
- Asrar B. Malik, PhD
Distinguished Professor and Department Head
- Dolly Mehta, PhD
Assistant Professor
- Richard D. Minshall, PhD
Associate Professor
- Shigehiro Nakajima, MD, PhD
Professor
- John P. O'Bryan, PhD
Assistant Professor
- Miodrag Radulovacki, MD, PhD
Professor
- Randal A. Skidgel, PhD
Professor
- Karen Snapp, PhD
Assistant Professor
- Chinnaswamy Tiruppathi, PhD
Associate Professor
- Masuko Ushio-Fukai, PhD
Associate Professor
- Tatyana Voyno-Yasenetskaya MD, PhD
Associate Professor
- Kishore K. Wary, PhD
Assistant Professor
- Richard D. Ye, MD, PhD
Professor
- You-Yang Zhao, PhD
Assistant Professor
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John P. O'Bryan, PhD
Assistant Professor of Pharmacology
The temporal and spatial regulation of signal transduction pathways is paramount to the normal growth, development and homeostatic
regulation of an organism. Disruption of these regulatory pathways has profound consequences, underlying many pathological conditions including
neurodegeneration, cancer and cardiovascular disease. The research in our lab is aimed at understanding the role of scaffolding proteins in
coordinating signal transduction pathways. This class of molecules consists predominantly of protein:protein interaction domains and functions to
assemble multi-protein complexes that regulate cellular biochemical pathways. The current focus is on the unique, multi-domain scaffold intersectin
(ITSN), which coordinates the processes of endocytosis and signal transduction and thus contributes to cell growth, differentiation, and survival.
4091 CoMRB
909 S. Wolcott Ave.
(312) 996-6221
obryanj@uic.edu
Lab home page
Publications
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