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NIH Pharmacological Sciences Training Faculty

Name/Degree
Rank
Primary (& Secondary)
Appointment(s)
Role(s)
Research Interests
Asrar B. Malik, PhD Distinguished Professor and Head Pharmacology
(Center for Lung and Vascular Biology)		 Program Director
Advisory Committee
Preceptor		 Regulation of barrier property of lung endothelial cells; cellular and molecular basis of lung endothelial activation and injury; neutrophil/endothelial interactions.
Steven J. Ackerman, PhD Professor Biochemistry and
Molecular Genetics
(Medicine)		 Executive Committee
Preceptor		 Transcriptional mechanisms regulating development and gene expression; biology of eosinophils and their role in inflammation.
Sarah B. Appel, PhD Professor Physiology and Biophysics Executive Committee
Preceptor		 Electrophysiological studies of dopaminergic neurons of the ventral tegmental area and noradrenergic neurons of the locus coeruleus; drug and neurotransmitter effects; mechanism of action of alcohol.
William T. Beck, PhD Professor and Head Biopharmaceutical Sciences Advisory Committee
Preceptor		 Molecular pharmacology and genetics of anticancer drug action and tumor cell drug resistance.
Judy L. Bolton, PhD Professor and Head Medicinal Chemistry and Pharmacognosy Advisory Committee
Preceptor		 Oxidative metabolism of catechols and phenols to genotoxic metabolites.
Athar Chishti, PhD Professor Pharmacology Preceptor Organization and regulation of cytoskeleton; role of calpain in platelet and neutrophil activation, and in inflammation.
Oscar Colamonici, MD Associate Professor Pharmacology Preceptor Characterization of structure of interferon receptor and cytokine signaling.
Pieter de Tombe, PhD Associate Professor Physiology and Biophysics (Medicine, Section of Cardiology) Preceptor Cardiovascular physiology, muscle contraction, cardiac energetics, ventricular-arterial coupling, cardiac pump function.
Xiaoping Du, MD, PhD Professor Pharmacology Preceptor Mechanisms and molecular pharmacology of platelet activation; platelet and endothelial cell interactions.
Norman Farnsworth, PhD Professor Medicinal Chemistry and Pharmacognosy Advisory Committee
Preceptor		 Isolation and structure elucidation of biologically active principles from natural sources.
Scott G. Franzblau, PhD Professor Medicinal Chemistry and Pharmacognosy Preceptor New drug discovery from natural and synthetic sources for tuberulosis and other mycobacterioses.
Richard A. Gemeinhart, PhD Assistant Professor Biopharmaceutical Sciences Preceptor Polymer-drug conjugates for peptide, protein and chemo
Thomas M. Guenthner, PhD Professor Pharmacology Associate Director
Executie Commitee		 Enzymology of drug metabolism
Michael E. Johnson, PhD Professor Medicinal Chemistry and Pharmacognosy Preceptor Nuclear magnetic resonance studies of protein and peptide 3D structure, macromolecule-ligand interactions, computer-aided design and structural bioinformatics.
Jack Kaplan, PhD, FRS Professor and Head Biochemistry and Molecular Genetics Advisory Committee
Preceptor		 Molecular studies of P-type ATPases or ion pumps.
Tohru Kozasa, MD, PhD Associate Professor Pharmacology Preceptor Biochemical investigations of G protein-mediated signal transduction pathways.
Alan P. Kozikowski, MD Professor Medicinal Chemistry and Pharmacognosy Preceptor Drug discovery involving cocaine abuse medications, mGluR ligands, PKC activators, inhibitors of PI-3K, casoase inhibitors, and huperzine A.
Stephen C.-T. Lam, PhD Associate Professor Pharmacology Preceptor Role of platelet adhesive functions in hemostasis and thrombosis.
Lester F. Lau, PhD Professor Biochemistry and Molecular Genetics Preceptor Angiogenesis, cell growth, and differentiation.
Guy C. Le Breton, PhD Professor Pharmacology Executive Committee
Preceptor		 Mechanisms in platelet activation via thromoxane A2 receptors and its inhibition; pharmacological prevention and management of thrombosis.
Alexander S. Mankin, PhD Professor Medicinal Chemistry and Pharmacognosy Preceptor Antiobiotic resistance mutations in rRNA genes, mechanisms of action of ribosome-targeted antibiotics.
Andrew D. Mesecar, PhD Assistant Professor Medicinal Chemistry and Pharmacognosy Preceptor Role of protein dynamics and conformational change in molecular recognition and enzymatic catalysis.
Richard D. Minshall, PhD Associate Professor Anesthesiology
(Pharmacology)
(Center for Lung and Vascular Biology)		 Preceptor Paracellular and transcellular transport; signaling mechanisms regulating permeability of lung endothelium to macromolecules.
Shigehiro Nakajima, MD, PhD Professor Pharmacology Preceptor Pharmacological and electrophysiological investigators on various receptors and channels in brain neurons with emphasis on signal transduction mechanisms.
Hayat Onyuksel, PhD Professor and Associate Head Biopharmaceutical Sciences (Bioengineering) Preceptor Formulation and delivery of peptide and protein drugs using lipid-based carrier systems.
Sergey V. Popov, PhD Associate Professor Physiology and Biophysics Preceptor Mechanisms of nerve growth in synaptic transmission.
Miodrag Radulovacki, MD, PhD Professor Pharmacology
(Medicine-Section of Pulmonary, Critical Care, and Sleep Medicine)		 Preceptor Pathogenic mechanisms of sleep apnea.
Mrinalini C. Rao, PhD Professor Physiology and Biophysics (Medicine, Section of Digestion and Liver Diseases) Preceptor Regulation of water and electrolyte transport across epithelia.
Mark M. Rasenick, PhD Professor Physiology and Biophysics Preceptor Cytoskeletal modulation of G protein signal transduction.
Randal A. Skidgel, PhD Professor Pharmacology
(Anesthesiology)
(Center for Lung and Vascular Biology)		 Preceptor Analysis of enzymes controlling activity of peptide hormones in lung; regulation of NO production in endothelial cells via carboxypeptidases.
Karen Snapp, PhD Assistant Professor Pharmacology Executive Committee
Preceptor		 Adhesion and migration mediated by P-selectin and its ligands.
R. John Solaro, PhD Professor and Head Physiology and Biophysics (Medicine, Section of Cardiology) Advisory Committee
Preceptor		 Integrated molecular, structural, and
Steven M. Swanson, PhD Associate Professor Medicinal Chemistry and Pharmacognosy Executive Committee
Preceptor		 Evaluation of the mechanism of action of anticancer agents.
Chinnaswamy Tiruppathi, PhD Associate Professor Pharmacology
(Center for Lung and Vascular Biology)		 Preceptor Synergistic actions of TNFalpha and thrombin in endothelial cell activation; role of Ca2+ signaling in NF-kappaB activation.
Debra A. Tonetti, PhD Assistant Professor Biopharmaceutical Sciences Executive Committee
Preceptor		 Molecular mechanisms of tamoxifen resistance in breast cancer.
Richard B. van Breemen Professor Medicinal Chemistry and Pharmacognosy Preceptor Biomedical mass spectrometry, bioavailability and metabolism of nutrients and therapeutic agents.
Tatyana Voyno-Yasenetskaya, MD, PhD Associate Professor Pharmacology
(Center for Lung and Vascular Biology)		 Preceptor Study of heterotrimeric G proteins involved in endothelial activation.
Zajie Jim Wang, PhD Assistant Professor Biopharmaceutical Sciences Preceptor Molecular mechanisms, interventions and targeting of neuropathic pain.
Richard Ye, MD, PhD Professor Pharmacology
(Microbiology and Immunology)
(Center for Lung and Vascular Biology)		 Preceptor Chemoattractant activation of phagocytes and generation of directed cell migration and degranulation.

 
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