Haixia Gong , MD, PhD
Research Assistant Professor
Regulation of Endothelium Permeability by Galpha13.
The endothelium functions as a semi-permeable barrier regulating tissue fluid homeostasis and transmigration of leukocytes and providing essential nutrients across the vessel wall. Increased endothelium permeability plays key roles in inflammation, tissue injury, and edema, et al. Over the past years there have been particularly rapid advances in understanding how VE-cadherin, the major component of endothelial cell adhesion junction regulates endothelium permeability. But whether and how Galpha13 regulates endothelium permeability by interacting with VE-cadherin still keeps mystery. My research interest is focus on the mechanism of Galpha13-regulated VE-cadherin signaling pathway. The insight of this research is expected to answer some long-standing questions and provide novel pharmacological targets for abnormal endothelium permeability-related diseases.
909 S. Wolcott Ave.
Haixia Gong, Bo Shen, Panagiotis Flevaris, et al. G protein subunit Gα13 binds to integrin α2bβ3 and mediates integrin “outside-in” signaling. Science. 2010: 327 (5963): 340-3.
Panagiotis Flevaris, Aleksandra Stojanovic, Haixia Gong, et al. A molecular switch that controls cell spreading and retraction. J Cell Bio. 2007: 179 (3): 553-65.
Guo Xirong, Haixia Gong, Yanqin Gao, et al. A mutation in the signal peptide of rat resistin gene inhibits 3T3-L1 preadipocytes differentiation. Acta Pharmacol Sin. 2004, 25 (12): 1705-11.
Haixia Gong, Yuhui Ni, Xirong Guo, et al. Resistin promotes 3T3-L1 preadipocyte differentiation. Eur J Endocrinol, 2004, 50(6): 885-92.
Haixia Gong, Xirong Guo, Li Fei, et al. Apoptosis and lipolysis of adipocytes induced by neuropeptide Y-Y5 receptor antisense oligodeoxynucleotides in obese rats. Acta Pharmacol Sin. 2003, 24(6): 569-75.