Research Interests

Research interests of this laboratory are in the field of thrombosis, hemostasis, and vascular biology. The focus of my research is to understand the signaling mechanisms that regulate platelet activation.

Selected Publications

• Li Z, Zhang G, Feil R. Han J, Du X. Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin aIIbb3. Blood. 2005. In press.


• Li Z, Zhang G, Marjanovic JA, Ruan C, Du X. A platelet secretion pathway mediated by cGMP-dependent protein kinase. J Biol Chem. 2004 Oct 8; 279(41): 42469-75.


• Du X, Marjanovic JA, Li Z. On the roles of cGMP and glycoprotein Ib in platelet activation. Blood. 2004 Jun 1; 103(11): 4371-2


• Xi X, Bodnar RJ, Li Z, Lam SC, Du X. Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling. J Cell Biol. 2003 Jul 21; 162(2): 329-39.


• Li Z, Zhang G, Le Breton GC, Gao X, Malik AB, Du X. Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases. J Biol Chem. 2003 Aug 15;278(33): 30725-31


• Li Z, Ajdic J, Eigenthaler M, Du X. A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans. Blood. 2003 Jun 1; 101(11): 4423-9.


• Li Z, Xi X, Gu M, Feil R, Ye RD, Eigenthaler M, Hofmann F, Du X. A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell. 2003 Jan 10; 112(1):77-86.


• Bodnar RJ, Xi X, Li Z, Berndt MC, Du X. Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta). J Biol Chem. 2002 Dec 6; 277(49): 47080-7


• Li Z, Xi X, Du X. A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3. J Biol Chem. 2001 Nov 9; 276(45): 42226-32.


• Bodnar RJ, Gu M, Li Z, Englund GD, Du X. The cytoplasmic domain of the platelet glycoprotein Ibalpha is phosphorylated at serine 609. J Biol Chem. 1999 Nov 19; 274(47): 33474-9.