Research Interests

My research interests focus on investigating the mechanisms of acute lung injury and developing new therapies and interventions for acute lung injury.

Ongoing Research Targets:

1) Activation of alpha 7 acetylcholine nicotinic receptor (α7 nAChR) attenuates acute lung inflammation and injury and regulates function of endothelial progenitor cells. 2) CFTR regulates proinflammatory responses in alveolar macrophages and neutrophils and affects the outcome of acute lung injury and cystic fibrosis. 3) The role of protease activated receptors (PAR1, PAR2) in acute lung inflammation and injury.

E421 MSB
835 S. Wolcott Ave.
(312) 996-1259
xiaosu@uic.edu

• Su X*, Johansen M, Looney MR, Brown EJ, Matthay MA. CD47 Deficiency protects mice from LPS-induced acute lung injury and E.coli pneumonia. J Immunol. 2008, 180: xxxx. (in press) *Corresponding author.
• Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. Neutrophils and their Fcγ receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006, 116:1615-23.
• Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA. PAR2 activation induces acute lung inflammation by neuropeptide dependent mechanisms. J Immunol. 2005, 175: 2598-2605.
• Matthay MA, Su X. Pulmonary barriers to pneumonia and sepsis.  Nature Med. 2007, 13 (7):780-781. 
• Su X*, Looney MR, Lee JW, Song Y, Matthay MA.  Lack of functional CFTR in alveolar macrophages and neutrophils worsens E. coli endotoxin-induced acute lung injury in mice. J Exp Med. (2008, submitted) *Corresponding author.  
• Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D. Ligation of protease-activated receptor 1 enhances αvβ6 integrin-dependent TGF-β activation and promotes acute lung injury. J Clin Invest. 2006, 116:1606-1614.
• Su X*, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA. Activation of the α7 Nicotinic acetylcholine receptor reduces acid-induced acute lung injury in mice and rats. Am J Respir Cell Mol Biol. 2007; 37(2):186-192. *Corresponding author.
• Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. Intrapulmonary delivery of bone marrow derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol. 2007; 179(3), 1855-1863.
• Su X*, Robriquet L, Folkesson HG, Matthay MA. Protective effect of endogenous β-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2006, 290: L769-776. *Corresponding author.