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Primary Faculty
- Athar H. Chishti, PhD
Professor
- Oscar Colamonici, MD
Associate Professor
- Xiaoping Du, MD, PhD
Professor
- Tohru Fukai, MD, PhD
Associate Professor
- Thomas M. Guenthner, PhD
Professor
- Tohru Kozasa, MD, PhD
Associate Professor
- Stephen C.-T. Lam, PhD
Associate Professor
- Guy C. Le Breton, PhD
Professor
- Asrar B. Malik, PhD
Distinguished Professor and Department Head
- Dolly Mehta, PhD
Assistant Professor
- Richard D. Minshall, PhD
Associate Professor
- Shigehiro Nakajima, MD, PhD
Professor
- John P. O'Bryan, PhD
Assistant Professor
- Miodrag Radulovacki, MD, PhD
Professor
- Randal A. Skidgel, PhD
Professor
- Karen Snapp, PhD
Assistant Professor
- Chinnaswamy Tiruppathi, PhD
Associate Professor
- Masuko Ushio-Fukai, PhD
Associate Professor
- Tatyana Voyno-Yasenetskaya MD, PhD
Professor
- Kishore K. Wary, PhD
Assistant Professor
- Richard D. Ye, MD, PhD
Professor
- You-Yang Zhao, PhD
Assistant Professor
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Karen Snapp, PhD
Assistant Professor of Pharmacology
Our laboratory is interested in the cellular events that occur during selectin-mediated adhesion. The selectins
are expressed on endothelium, platelets and leukocytes, and play a crucial role in leukocyte recruitment during an inflammatory response.
Following interactions between endothelial selectins and PSGL-1, a leukocyte selectin ligand, the leukocyte undergoes a massive cytoskeletal
rearrangement as it rolls along the endothelial surface. PSGL-1 clusters, associates with the actin cytoskeleton, and migrates to the
cellular uropod. These observations have led us to explore the cytoskeletal proteins and signaling pathways that are activated during
PSGL-1 mediated leukocyte rolling.
4093 CoMRB
909 S. Wolcott Ave.
(312) 355-3803
krs@uic.edu
Lab home page
Publications
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