A tumor composed of embryonal cell layers is a:

a. adenocarcinoma
b. Carcinosarcoma
c. mixed mesodermal tumor
d. teratoma
e. papillary adenocarcinoma

A mass composed of normal tissues native to the location but in abnormal amount or arrangement is called a (n)

a. hamartoma
b. teratoma
c. mixed tumor
d. choristoma
e. embryonal tumor

Loss of orderly maturation of epithelium is best called:

a. hamartoma
b. teratoma
c. dysplasia
d. choristoma
e. embryonal tumor

A lesion on an epithelial body surface characterized by nuclear hyperchromatism, disturbance of cell polarity and cellular invasion through the basement membrane is

a. papilloma
b. carcinoma
c. carcinoma-in-situ
d. hair follicle
e. hamartoma

A histologically anaplastic tumor would be expected to behave in what way?

a. slow growth, late metastasis
b. benign
c. rapid growth, early metatasis
d. slow growth, no metastasis
e. stable through life of patient

A single mitotic figure in a microscopic tissue section means that the tissue is:

a. neoplastic
b. poorly differentiated
c. composed of some replicating cells
d. anaplastic
e. hypertrophic

Principal criteria by which a diagnosis of cancer is made in a primary lesion include:

a. rate of tumor growth
b. degree of cytologic anaplasia
c. number of mitoses
d. evidence of tumor invasion
e. all of the above

Which of the following is NOT a malignant tumor?

a. hepatoma
b. lymphoma
c. melanoma
d. leiomyoma
e. medulloblastoma

A fibroadenoma of the breast is an example of:

a. hyperplasia
b. metaplasia
c. neoplasia
d. dysplasia
e. anaplasia

Malignant neoplasms may follow:

a. a non-lethal high dose of gamma irradiation
b. repeated benzene exposure
C. asbestos inhalation
e. actinic keratosis of the skin
f. all of the above

Benign cystic teratoma (dermoid cysts) occur in the:

a. ovary
b. testes
c. mediastinum
d. sacrococcygeal area
e. all of the above

Where chronic hemorrhage or superimposed infection are not contributing factors, the most common way in which malignancy leads to death is through:

a. heart failure
b. thrombosis and infarction
c. renal failure
d. cachexia
e. metastasis to the brain

The single most important factor in predicting the probable course of a malignant neoplasm is:

a. number of mitotic figures per high power field
b. the size of the neoplasm when first diagnosed
c. the degree of anaplasia of the neoplasm
d. degree of clinical response to radiation or chemotherapy
e. the presence or absence of metastases at the time of diagnosis

Workers in the aniline dye industry are most prone to which one of the following tumors?

a. carcinoma of the lung
b. carcinoma of the stomach
c. squamous cell carcinoma of the skin
d. basal cell carcinoma of the skin
e. carcinoma of the urinary bladder

Which of the following viruses is most likely implicated in the causation of human malignancy?

a. measles virus
b. Epstein-Barr virus
c. cytomegalo virus
d. rhinovirus
e. coxsackie virus

staging of tumors helps with which of the following?

a. determination of prognosis
b. determination of treatment
c. determination of common language for cancer specialists
d. determination of strata in clinical trials
e. all of the above

Most commonly staging considers the following?

a. tumor size
b. nodal involvement
c. presence or absence of metastatic disease
d. none of the above
e. all of the above

Recruitment in tumor cell kinetics is best described by:

a. shortening the S phase
b. decrease in cell cycle time
c. decrease in size of Go compartment
d. decrease in size of N compartment
e. increase in size of Go compartment

The single most important feature of malignancy is:

a. cellular pleomorphism
b. numerous mitotic figures
c. metastases
d. lymphocytic infiltration at the edges of the tumor
e. plasma cell infiltration at the edges of the tumor

A tumor composed of columnar epithelium arranged in glandular configuration with nests of cells invading into adjacent normal tissue is best described as:

a. adenomatous polyp
b. adenomatous hyperplasia
c. adenomyosis
d. adenocarcinoma
e. carcinosarcoma

An increase in tissue associated with an increase in the number of cells composing the tissue is best described as:

a. aplasia
b. agenesis
c. hypertrophy
d. hyperplasia
e. metaplasia

Direction: Each group of lettered words or phrases is followed by a list of numbered statements. Match the numbered statement most closely associated with the lettered word or phrase. Each lettered word or phrase may be used once, more than once, or not at all.

A. malignant neoplasm
B. benign neoplasm
C. hyperplasia
D. aplasia
E. teratoma
F. metaplasia

lipoma

questions 28 through 30

Directions:Each set of lettered headings below is followed by a list of numbered words or phrases. For each numbered word or phrase select:

A. if the item is associated with A only
B. if the item is associated with B only
C. if the item is associated with A and B
D. if the item is associated with neither A nor B

Exhibit the phenomenon of contact inhibition in vitro

Questions 31 and 32 only

Directions: For each of the following statements ONE or MORE answers are correct.

Answer:

A. if only 1, 2, and 3 are correct
B. if only 2 and 3 are correct
C. if only 2 and 4 are correct
D. if only 4 is correct
E. if some other combinations is correct

The synthesis of DNA occurs during only a portion of the cell cycle i.e the S phase. In the presence of adequate amounts of nutrients and growth factors, the control of DNA synthesis is:

1. programmed during G1
2. an all or none event which follows the G1 phase
3. associated with the synthesis of histones and other cellular proteins
4. determined by the rate of transport of glucose across the cell surface membrane and the intracellular level of deoxyribonucleoides

The length of the cell cycle is determined mainly by the length of:

A. the S phase
B. G1
C. The G2 phase
D. the M phase

In the presence of adequate nutrients and growth factors, the length of the S phase is believed to be determined by:

A. the rate of DNA synthesis along the replication fork
B. the number of replication bubbles per chromosome
C. the number of replication forks per nucleosome
D. the number of Okazaki fragments per replication fork