Biopsy - Ocular Cicatricial Pemphigoid
strip of tissue should be taken and divided into two samples: one
sample should be fixed in formalin and submitted for light microscopy;
the other sample should be placed into transport media for immunopathology.
If you do not have transport media, please contact
us and we will ship it to you by overnight courier. We suggest
processing tissue for permanent sections because rarely neoplastic
conditions, such as intraepithelial spread of sebaceous carcinoma,
can give false positive readings by immunohistochemistry. Also, intraepithelial
sebaceous carcinoma may mimic pemphigoid clinically and histologically
(by creating the illusion of bullous separation of the epithelium).
biopsy for pemphigoid. Note the bullous separation of the epithelium
from the scarred and inflammed substantia propria. The diagnosis was
confirmed by the detection of linear deposits of compliment and immunoglobulin
along the epithelial basement membrane.
handle the tissue gently and prepare it properly
for submission to the laboratory.
you have more questions about conjunctival biopsy for pemphigoid, please
contact one of us:
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