most common indication for cyclectomy is removal of a neoplasm involving
the peripheral iris and/or the ciliary body.
cyclectomy procedures are excisional biopsy: the goal of the resection
is to excise the lesion entirely. A deceptively large amount of iris
tissue may need to be resected to ensure that the lateral resection
margins are not involved by tumor.
order for the pathologist to evaluate the tissue sample margins, it
is important that the iris tissue component of the resected tissue not
curl after being placed in formalin.
surgeon should place the resected tissue on a flat mount of absorbable
material and allow moisture from the specimen to run off into the
mount until the tissue sample adheres to the mount (no longer than
mount with the adherent tissue should be placed as an open-faced
sandwich into a collection vial with formalin. Agitate the vial
gently until the mount and tissue sink into the container.
histologic evaluation of heavily pigmented tumors such as melanocytomas
or melanomas may require the preparation of slides that are bleached
to remove melanin.
pathologist has two goals:
the correct diagnosis.
the resection margins.
histologic differential diagnosis is narrow: melanoma, melanocytoma,
leiomyoma, and focal granuloma.
the gross examination, it is important to sample the lateral and medial
resection margins. It is also important to comment on the posterior
resection margin. The anterior margin is most likely the pupillary border
and not a true resection margin.
is helpful to section the specimen between the crests of the pars plicata
to ensure proper orientation.
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