Uveal Melanoma: A Tumor Developing in a Special Immune Environment
The immunological response to uveal melanoma is strikingly different from that seen in cutaneous melanoma.. In cutaneous melanoma, for example, the presence of numerous tumor infiltrating lymphocytes is associated with a favorable outcome, but in most studies of uveal melanoma, the presence of tumor infiltrating lymphocytes is associated with poor survival.
Suggested References:
de la Cruz PO Jr, et al. Lymphocytic infiltration in uveal malignant melanoma. Cancer 1990;65:112-115.
Rummelt V, et al. Relation between the microcirculation architecture and the aggressive behavior of ciliary body melanomas. Ophthalmology 1995;102:844-851.
The immunologic characterization of uveal melanoma is the subject of intense research in other laboratories.
Suggested References:
Jager MJ, et al. HLA expression in uveal melanoma: There is no rule without some exception. Hum Immunol 2002;63:444-451.
Ksander BR, et al. Uveal melanomas contain antigenically specific and non-specific infiltrating lymphocytes. Curr Eye Res 1998;17:165-173.
Niderkorn JY. Immunoregulation of intraocular tumours. Eye 1997;11:249-254.