Stephen Lasley, Ph.D.
Research Professor, Cancer Biology and Pharmacology, UICOM-Peoria
Cellular/Molecular, Disease/Therapeutics
Mechanisms of lead neurotoxicity affecting synaptic plastitcity, especially those involving neurotrophin activity; therepeutic approaches for chronic uranium neurotoxicity.
Selected references
- Gilbert ME, Lasley SM. Long-term consequences of developmental exposure to lead or polychlorinated biphenyls: Synaptic transmission and plasticity in the rodent CNS. Environ. Toxicol. Pharm. 2002;12:105-117.
- Gilbert ME, Lasley SM. Developmental lead exposure reduces the ability of the NMDA antagonist M-801 to suppress long-term potentiation in the rat dentate gyrus, in vivo. Neurotoxical. Teratol. 2007;29:385-393.
- Vietti KRN, Lasley SM. Stimulus-evoked glutamate release is diminished by acute exposure to uranium in vitro. Neurotoxicol Teratol. 2007;29:607-612.