Noam Alperin, Ph.D.
Associate Professor, Radiology, Bioengineering
Integrative Systems, Disease/Therapeutics
Normal brain function requires regulation of physiologic parameters such as cerebral blood flow (CBF), perfusion and intracranial pressure (ICP). In many neurological problems this regulation is disrupted. Our NIH funded multi disciplinary research focuses on development of imaging-based methods to quantify the intracranial physiology, noninvasively, by MRI.
Selected references
- Alperin N, Lichtor T, Mazda M, Lee SH. From Cerebrospinal Fluid Pulsation to Noninvasive Intracranial Compliance and Pressure Measured by MRI Flow Studies. Current Medical Imaging Reviews, Current Medical Imaging Reviews, 2006(2); 117-129.
- Alperin N, Lee S, Sivaramakrishnan A, Hushek S. Quantifying the Effect of Posture on Intracranial Physiology in Humans by MRI Flow Studies. J Magn Reson Imaging. 2005 Nov;22(5):591-596.
- Alperin N, Lee SH, Loth F, Raksin P, Lichtor T. MR-Intracranial Pressure (ICP): A method for noninvasive measurement of intracranial pressure and elastance. Baboon and Human Study. Radiology. 2000; 217(3); 877885.