Scott T. Brady, Ph.D.
Professor & Head, Anatomy & Cell Biology
Cellular/Molecular, Disease/Therapeutics
Molecular Motors and Mechanisms of Axonal Transport; Neuronal Cytoskeleton; Glial Modulation of Neurons; Effects of Physiological Stress on neurons; Neurodegeneration.
Selected references
- Morfini, G., Pigino, G., Szebenyi, G., You, Y., Pollema, S., and Brady, S. T. JNK Mediates Pathogenic Effects of Polyglutamine-expanded Androgen Receptor on Fast Axonal Transport. Nature Neurosci, 2006; 9: 907-916.
- Lazarov, O., Morfini, G. A., Pigino, G., Gadadhar, A., Chen, X., Robinson, J., Ho, H., Brady, S. T., and Sisodia, S. S. Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J Neurosci., 2007;27:7011-7020.
- Morfini, G., Pigino, G., Opalach, K., Serulle, Y., Moreira, J. E., Sugimori, M., Llinas, R. R., and Brady, S. T. 1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C. Proc Natl Acad Sci USA, 2007; 104:2442-2447.