Mary Jo LaDu, Ph.D.
Associate Professor, Anatomy & Cell Biology, Bioengineering
We study the hypothesis that structural and functional interactions among apolipoprotein E, amyloid-ß peptide and apolipoprotein E receptors influence the neurotoxicity associated with Alzheimer’s disease.
- Manelli, A.M., Bulfinch, L., Sullivan, P.M., and M.J. LaDu. Effect of Aß structure and human apoE isoform on primary co-cultures of neurons and glia. Neurobiology of Aging, 2007;28:1139-1147.
- Manelli, A.M., Stine Jr., W.B., Van Eldik, L.J. and M.J. LaDu. ApoE and Aß1-42 interactions: effects of isoform and conformation on structure and function. J. Mol. Neuroscience, 2004;23:235-246.
- Dahlgren, K.D., Manelli, A.M., Stine Jr., W.B., Baker, L.K., Krafft, G.A., and M.J. LaDu. Oligomeric and fibrillar species of amyloid-ß peptides differentially affect neuronal viability. J. Biol. Chem. 2002;277:32046-32053.