Orly Lazarov, Ph.D.
Assistant Professor, Anatomy & Cell Biology
Cellular/Molecular, Disease/Therapeutics
Cellular and molecular mechanisms underlying Alzheimer's disease; The cross talk between neurogenesis and Alzheimer's disease pathology; Stem cell therapeutics for the treatment of neurodegenerative diseases.
Selected references
- Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS. Non-cell autonomous effects of presenilin 1 variants on enrichment hippocampal progenitor cell proliferation and differentiation. Neuron. 2008 Aug 28; 59(4): 568-80.
- Lazarov O, Morfini GA, Pigino G, Gadadhar A., Chen X., Robinson J, Ho H, Brady ST, Sisodia SS. Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J Neurosci. 2007 Jun 27;27(26):7011-20
- Lazarov O, Peterson LD, Peterson DA, Sisodia SS. Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex. J Neurosci. 2006 Jan 11;26(2):429-34.