John P. Leonard, Ph.D.
Professor, Biological Sciences
Cellular/Molecular, Cognition/Learning
I am involved in parlaying information on receptor and channel structure-function studies, particularly modulation by phosphorylation, into testable mutations in whole animals.
Selected references
- Jones M.L., and Leonard J.P. PKC site mutations reveal differential modulation by insulin of NMDA receptors containing NR2A or NR2B subunits. J Neurochem. 2005 Mar;92(6):1431-8.
- Liao G-Y., Wagner D.A., Hsu M.H., and Leonard J.P. Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current. Mol Pharmacol. 2001 May;59(5):960-4.
- Wagner, D.A., and Leonard, J.P. Protein kinase C potentiation of currents from mouse zeta1/epsilon2 NMDA receptors expressed in Xenopus oocytes depends on f-actin/g-actin cycling. Neurosci Lett. 1999 Sep 17;272(3):187-90.