Gerardo A. Morfini, Ph.D.
Assistant Professor, Anatomy & Cell Biology
Cellular/Molecular, Disease/Therapeutics
Our laboratory studies basic properties of intracellular transport and its role in the pathogenesis of human neurodegenerative diseases.
Selected references
- Morfini G, Pigino G, Szebenyi G, You Y, Pollema S, Brady ST. "JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport" Nat Neurosci. 2006 Jul;9(7):907-16.
- Morfini G, Pigino G, Opalach K, Serulle Y, Moreira JE, Sugimori M, Llinás RR, Brady ST. 1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2442-7.
- DeBoer SR, You Y, Szodorai A, Kaminska A, Pigino G, Nwabuisi E, Wang B, Estrada-Hernandez T, Kins S, Brady ST, Morfini G. Conventional kinesin holoenzymes are composed of heavy and light chain homodimers. Biochemistry. 2008 Apr 15;47(15):4535-43.