John P. O'Bryan, Ph.D.
Assistant Professor, Pharmacology
Role of adaptor/scaffolding proteins in the regulation of signal transduction pathways, neuron survival/function,and neurodegenerative diseases.
- Das M, Scappini E, Martin NP, Wong KA, Dunn S, Chen YJ, Miller SL, Domin J, O'Bryan JP. Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway. Mol Cell Biol. 2007 Nov;27(22):7906-17.
- Scappini E, Koh TW, Martin NP, O'Bryan JP. Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase. Hum Mol Genet. 2007 Aug;16(15):1862-71.
- Miller SL, Scappini EL, O'Bryan J. Ubiquitin-interacting motifs inhibit aggregation of polyQ-expanded huntingtin. J Biol Chem. 2007 Mar;282(13):10096-103.