Rajiv Sharma, M.D.
Professor, Psychiatry
Cellular/Molecular, Disease/Therapeutics
Elucidating the mechanisms of epigenetic control in postmitotic neurons, the regulation of key epigenetic regulatory proteins, the relationship between neuronal depolarization and chromatin remodeling. Where direct translation into patient/human tissues is possible, then clinical protocols are designed and executed in patients with the major psychotic illnesses.
Selected references
- Sharma RP, Nguwah Tun. Grayson DR. Depolarization induces down-regulation of DNMT1 and DNMT3a mRNA in primary cortical cultures. Epigenetics. 2008;3(2):74-80.
- Sharma RP, Grayson DR, Gavin D. Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection. Schizophr Res. 2008a Jan;98(1-3):111-7.
- Gavin D, Kartan S, Chase K, Grayson DR, Sharma RP. Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects. Schizophr Res. 2008 Aug;103(1-3):330-2. Epub 2008 Jun 9.