Rajiv Sharma, M.D.
Elucidating the mechanisms of epigenetic control in postmitotic neurons, the regulation of key epigenetic regulatory proteins, the relationship between neuronal depolarization and chromatin remodeling. Where direct translation into patient/human tissues is possible, then clinical protocols are designed and executed in patients with the major psychotic illnesses.
- Sharma RP, Nguwah Tun. Grayson DR. Depolarization induces down-regulation of DNMT1 and DNMT3a mRNA in primary cortical cultures. Epigenetics. 2008;3(2):74-80.
- Sharma RP, Grayson DR, Gavin D. Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection. Schizophr Res. 2008a Jan;98(1-3):111-7.
- Gavin D, Kartan S, Chase K, Grayson DR, Sharma RP. Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects. Schizophr Res. 2008 Aug;103(1-3):330-2. Epub 2008 Jun 9.