Greg R.J. Thatcher , Ph.D.
Professor & Asst. Head, Medicinal Chemistry & Pharmacognosy
Approaches to neurodegenerative and affective disorders through modulating estrogenic and serotonergic pathways in the CNS and in particular NO/cGMP signaling. Design and synthesis of novel small molecules that modulate these pathways is complemented by cell based assays and study in animal behavioral models. One molecule has entered clinical trials for Alzheimer's disease.
- Bennett BM, Reynolds JN, Prusky GT, Douglas RM, Sutherland RJ, Thatcher GR. Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester. Neuropsychopharmacol. (2007), 32, 505-513.
- Thatcher GRJ, Bennett BM, Reynolds JN. NO chimeras as therapeutic agents in Alzheimer's disease. Curr Alzheimer Res. 2006 3:237-245.
- Thatcher GRJ, Bennett BM, Dringenberg HC, Reynolds JN. Novel nitrates as NO mimetics directed at Alzheimer's disease. J Alzheimers Dis. 2004 6:S75-84.