William A. Wolf, Ph.D.
Visiting Associate Professor, Anatomy & Cell Biology
Disease/Therapeutics, Cellular/Molecular
The central research theme is to understand adaptive changes in neuronal function (“neural plasticity”) that occur in psychiatric and neurologic disorders (e.g. Parkinson disease, drug abuse, stroke) with the goal of developing plasticity-targeted pharmacotherapy.
Selected references
- Papadopoulos, C.M., S.-Y. Tsai, V. Guillen, J. Ortega, G.L. Kartje and W.A. Wolf. Motor recovery and axonal plasticity with short-term amphetamine following stroke. Stroke (in press).
- Mignon, L. and W.A. Wolf. Postsynaptic 5-HT1A receptor stimulation increases motor activity in the 6-hydroxydopamine-lesioned rat: Implications for treating Parkinson’s disease. Psychopharmacol. (2007);192:49-59.
- Mignon, L. and W.A. Wolf (2005): 8-Hydroxy-2-(di-n-propylamino)tetralin reduces striatal glutamate in an animal model of Parkinson’s disease. NeuroReport (2005); 16: 699-703.