Events Calendar

Investigating the Impact of Bisphenols on Germline Function across Generations

October 18, 2017


3:30 PM - 4:30 PM

Seminar given by:
Patrick Allard, Ph.D
Assistant Professor
UCLA Institute for Society & Genetics
University of California
Los Angeles, CA
Abstract: Germ cells are the bridge between generations and their integrity is paramount to the health and viability of all organisms. As such, the dysregulation of germ cells development and function significantly contributes to infertility and is also the leading cause of birth defects and infant deaths in the United States. We investigated the effect of Bisphenols, Bisphenol A, and its substitute Bisphenol S, on germline homeostasis across generations. We show that BPA and BPS both disrupt normal germline function including the meiotic processes of homologous chromosome recombination and synapsis, although this is achieved through mostly different mechanisms. We also show that BPA alters the germline’s epigenetic control in a transgenerational manner through the disruption of the repressive histone marks H3K9me3 and H3K27me3. Together, these results highlight the need to examine toxicity pathways across a large developmental and generational time-span.

Location

Room 134-3 COP / E223 Rockford PHARM College of Pharmacy

Fee

None

Audience

General public/Campus community/Faculty/Staff/Students/Alumni/Prospective students

Website

pharmacy.uic.edu/departments/biopharmaceutical-sci . . .

Contact

tejada@uic.edu
312-996-0888

Category

Lectures, Seminars and Meetings

Department

Department of Biopharmaceutical Sciences

Last updated

10-04-2017

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