Seminar given by Dominic Raj, MD, DNB, FASN, FACP
Division of Renal Diseases and Hypertension
The George Washington University
Abstract: The human intestine is home to an extraordinarily complex and dynamic consortium of bacteria that play a pivotal role in human health and disease. Experimental and association studies indicate that dysbioses underpins a wide spectrum of chronic diseases such as atherosclerosis, hypertension, chronic kidney disease progression, metabolic disorders, autoimmune diseases, asthma, and autism. Alteration in gut microbiome resulting in generation of adverse gut-derived metabolites such as trimethylamine-N- oxide (TMAO), coupled with activation of inflammation promotes atherosclerosis. Fortunately, unlike the human genome, the gut microbiome has an adaptive and dynamic composition that is susceptible to manipulation and selective “farming” of desired microbial populations for the benefit of the human host. A number of approaches have been explored to leverage the therapeutic potential of microbiome ranging from probiotics and prebiotics to genetically engineer bacteria. Although exciting, these are preliminary findings, which are waiting to be tested in clinical settings.
Room B36 COP/ Room E226 Rockford PHARM College of Pharmacy
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Department of Biopharmaceutical Sciences