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Department of Anatomy and Cell Biology
University of Illinois at Chicago
LINA NIH, PH.D.
Project Research Leader
University of California Los Angeles
Department of Neurology
“Brain injectable hydrogels after stroke: a tissue engineering approach to treat the damaged brain”
Stroke is the leading cause of adult disability in the US. Despite limited tissue regeneration capacities, angiogenesis and neurogenesis have been described as the main critical phenomena involved in tissue repair and functional recovery. However, the overwhelming majority of brain repair research focuses on developing pro-neuronal therapies, leaving pro-vascular approaches largely unexplored. Promoting the formation of a functional vascular network in a highly inflamed and damaged tissue is challenging. This is particularly problematic when stem cell therapies are limited by poor survival and differentiation, and when growth factor delivery to the brain is associated with short half-life time and severe side effects. To circumvent these limitations, I have pursued a tissue engineering approach and developed pro-repair hydrogel-based biomaterials that can be directly injected in the site of damage. The hydrogel was systematically optimized to deliver vascular growth factor with spatiotemporal control, promote survival of encapsulated stem cells and precisely tune their differentiation, and reduce the post-stroke inflammatory response.
Wednesday, March 14, 2018 at 1:30 PM
Moss Auditorium (Room 1020)
College of Medicine Research Building
909 South Wolcott Avenue
Host: Simon Alford, Ph.D.
For more information, please contact the Department of Anatomy and Cell Biology at 312-996-6791 or firstname.lastname@example.org.
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1020 (Moss Auditorium) CMRB College of Medicine Research Building
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Anatomy and Cell Biology