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Department of Anatomy and Cell Biology
University of Illinois at Chicago
BRIAN PIERCHALA, PH.D.
Department of Biologic and Materials Sciences
University of Michigan School of Dentistry
“Development and regeneration of peripheral neural circuits”
During development of the nervous system, peripheral neurons and their axonal projections are supported by target-derived neuroptrophic factors, such as the neurotrophins and the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs). During this period of target innervation, neurons often make excessive projections into their targets that are later pruned back. In addition to target-derived survival factors, competing neurons release “competition factors” that actively “push out” weaker axonal connections, and subsequently induce the apoptotic death of these less successful neurons. The delicate balance between growth and survival-promoting neurotrophic factors, and inhibitory competitive factors, is thought to ultimately sculpt the architecture of mature circuits. My laboratory is interested in understanding the ligand and receptor mechanisms responsible for survival promotion, synaptic elimination, apoptosis and regeneration of peripheral neurons. We utilize biochemical and cell biological methods for the analysis of transgenic mice in which these receptors and ligands are deleted at specific developmental times. The determination of these mechanisms of survival, cell death and axonal regeneration will enable a more rational approach for the development of therapeutic strategies for diseases and injuries of the nervous system.
Monday, March 19, 2018 at 1:30 PM
Room 1020, Moss Auditorium
College of Medicine Research Building
909 South Wolcott Avenue
Host: Simon Alford, Ph.D.
For more information, please contact the Department of Anatomy and Cell Biology at 312-996-6791 or email@example.com.
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1020 CMRB CMRB College of Medicine Research Building
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