UIC College of Pharmacy The van Breemen LC-MS-MS Laboratory
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Selected Publications

  1. Gödecke T, Yao P, Napolitano JG, Nikolic D, Dietz BM, Bolton JL, van Breemen RB, Farnsworth NR, Chen SN, Lankin DC, Pauli GF., Integrated standardization concept for Angelica botanicals using quantitative NMR. Fitoterapia. 2011 Sep 1. [Epub ahead of print] Pubmed

  2. Yu R, Xiao L, Zhao G, Christman JW, van Breemen RB., Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2. J Pharmacol Exp Ther. 2011 Aug 24. [Epub ahead of print] Pubmed

  3. Li J, Gödecke T, Chen SN, Imai A, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Nikolić D. In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4. Xenobiotica. 2011 Aug 9. [Epub ahead of print] Pubmed

  4. Kondratyuk TP, Park EJ, Marler LE, Ahn S, Yuan Y, Choi Y, Yu R, van Breemen RB, Sun B, Hoshino J, Cushman M, Jermihov KC, Mesecar AD, Grubbs CJ, Pezzuto JM., Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Mol Nutr Food Res. 2011 Aug;55(8):1249-65. doi: 10.1002/mnfr.201100122. Epub 2011 Jun 29. Pubmed

  5. van Breemen RB, Sharifi R, Viana M, Pajkovic N, Zhu D, Yuan L, Yang Y, Bowen PE, Stacewicz-Sapuntzakis M., Antioxidant effects of lycopene in African American men with prostate cancer or benign prostate hyperplasia: a randomized, controlled trial. Cancer Prev Res (Phila). 2011 May;4(5):711-8. Epub 2011 Mar 23. Pubmed

  6. Park EJ, Kondratyuk TP, Morrell A, Kiselev E, Conda-Sheridan M, Cushman M, Ahn S, Choi Y, White JJ, van Breemen RB, Pezzuto JM., Induction of retinoid X receptor activity and consequent upregulation of p21WAF1/CIP1 by indenoisoquinolines in MCF7 cells. Cancer Prev Res (Phila). 2011 Apr;4(4):592-607.Pubmed

  7. Hu C, Eggler AL, Mesecar AD, van Breemen RB., Modification of keap1 cysteine residues by sulforaphane. Chem Res Toxicol. 2011 Apr 18;24(4):515-21. Epub 2011 Mar 10. Pumed

  8. Castelvetri LC, Givogri MI, Zhu H, Smith B, Lopez-Rosas A, Qiu X, van Breemen RB, Bongarzone ER. Axonopathy is a compounding factor in the pathogenesis of Krabbe disease. Acta Neuropathol. 2011 Jul;122(1):35-48. Epub 2011 Mar 4. Pubmed

  9. Choi Y, Jermihov K, Nam SJ, Sturdy M, Maloney K, Qiu X, Chadwick LR, Main M, Chen SN, Mesecar AD, Farnsworth NR, Pauli GF, Fenical W, Pezzuto JM, van Breemen RB., Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Anal Chem. 2011 Feb 1;83(3):1048-52. Epub 2010 Dec 30. Pubmed

  10. Yang JH, Kondratyuk TP, Jermihov KC, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Huang R, Liu Y, Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, Fong HH, Chen YG, Zhang HJ., Bioactive compounds from the fern Lepisorus contortus. J Nat Prod. 2011 Feb 25;74(2):129-36. Epub 2011 Jan 24. Pubmed

  11. Chen SN, Friesen JB, Webster D, Nikolic D, van Breemen RB, Wang ZJ, Fong HH, Farnsworth NR, Pauli GF., Phytoconstituents from Vitex agnus-castus fruits. Fitoterapia. 2011 Jun;82(4):528-33. Epub 2010 Dec 13. Pubmed

  12. van Breemen RB, Tao Y, Li W., Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011 Jan;82(1):38-43. Epub 2010 Sep 15.Pubmed

  13. Cao H, Yu R, Tao Y, Nikolic D, van Breemen RB., Measurement of cyclooxygenase inhibition using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2011 Jan 5;54(1):230-5. Epub 2010 Aug 13.Pubmed

  14. Marler L, Conda-Sheridan M, Cinelli MA, Morrell AE, Cushman M, Chen L, Huang K, van Breemen R, Pezzuto JM., Cancer chemopreventive potential of aromathecins and phenazines, novel natural product derivatives. Anticancer Res. 2010 Dec;30(12):4873-82. Pubmed

  15. Dong L, Shion H, Davis RG, Terry-Penak B, Castro-Perez J, van Breemen RB., Collision Cross-Section Determination and Tandem Mass Spectrometric Analysis of Isomeric Carotenoids Using Electrospray Ion Mobility Time-of-Flight Mass Spectrometry. Anal Chem. 2010 Oct 7. Pubmed

  16. Guo J, Peng D, Dai Q, Liao S, Wright BJ, van Breemen RB., Quantitative analysis of 3alpha,6alpha,24-trihydroxy-24,24-di(trifluoromethyl)-5beta-cholane, a potent synthetic steroidal liver X receptor agonist in plasma using liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jul 1;878(21):1885-8. Pubmed

  17. Hoshino J, Park EJ, Kondratyuk TP, Marler L, Pezzuto JM, van Breemen RB, Mo S, Li Y, Cushman M., Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem. 2010 Jul 8;53(13):5033-43. Pubmed

  18. Wang Z, Chandrasena ER, Yuan Y, Peng KW, van Breemen RB, Thatcher GR, Bolton JL.Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens. Chem Res Toxicol. 2010 Aug 16;23(8):1365-73. Pubmed

  19. Dahl JH, van Breemen RB., Rapid quantitative analysis of 8-iso-prostaglandin-F(2alpha) using liquid chromatography-tandem mass spectrometry and comparison with an enzyme immunoassay method. Anal Biochem. 2010 Sep 15;404(2):211-6. Epub 2010 May 25. Pubmed

  20. Bolca S, Li J, Nikolic D, Roche N, Blondeel P, Possemiers S, De Keukeleire D, Bracke M, Heyerick A, van Breemen RB, Depypere H., Disposition of hop prenylflavonoids in human breast tissue. Mol Nutr Food Res. 2010 Jul;54 Suppl 2:S284-94. Pubmed

  21. Cao H, Yu R, Choi Y, Ma ZZ, Zhang H, Xiang W, Lee DY, Berman BM, Moudgil KD, Fong HH, van Breemen RB., Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation. Pharmacol Res. 2010 Jun;61(6):519-24. Epub 2010 Feb 24.Pubmed

  22. Van Loo-Bouwman CA, Naber TH, van Breemen RB, Zhu D, Dicke H, Siebelink E, Hulshof PJ, Russel FG, Schaafsma G, West CE.,Vitamin A equivalency and apparent absorption of beta-carotene in ileostomy subjects using a dual-isotope dilution technique. Br J Nutr. 2010 Jun;103(12):1836-43. Epub 2010 Feb 5. Pubmed

  23. Yang JH, Kondratyuk TP, Marler LE, Qiu X, Choi Y, Cao H, Yu R, Sturdy M, Pegan S, Liu Y, Wang LQ, Mesecar AD, van Breemen RB, Pezzuto JM, Fong HH, Chen YG, Zhang HJ., Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata. Phytochemistry. 2010 Apr;71(5-6):641-7. Epub 2010 Jan 25. Pubmed

  24. Cuendet M, Guo J, Luo Y, Chen S, Oteham CP, Moon RC, van Breemen RB, Marler LE, Pezzuto JM., Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice. Cancer Prev Res (Phila). 2010 Feb;3(2):221-32. Epub 2010 Jan 12. Pubmed
  25. Nikolić D., A liquid chromatography-mass spectrometric assay for measuring activity of human 8-oxoguanine-DNA glycosylase. Anal Biochem. 2010 Jan 15;396(2):275-9. Epub 2009 Sep 24. Pubmed
  26. He B, Velaparthi S, Pieffet G, Pennington C, Mahesh A, Holzle DL, Brunsteiner M, van Breemen R, Blond SY, Petukhov PA., Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) Approach: Mapping the Binding Poses of HDAC8 Inhibitors. J Med Chem. 2009 Nov 26;52(22):7003-7013. Pubmed
  27. Mao J, Yuan H, Wang Y, Wan B, Pieroni M, Huang Q, van Breemen RB, Kozikowski AP, Franzblau SG., From Serendipity to Rational Antituberculosis Drug Discovery of Mefloquine-Isoxazole Carboxylic Acid Esters., J Med Chem. 2009 Nov 26;52(22):6966-6978. Pubmed
  28. Tao Y, Li W, Liang W, Van Breemen RB., Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry., J Agric Food Chem. 2009 Nov 11;57(21):10014-21. Pubmed
  29. Geller SE, Shulman LP, van Breemen RB, Banuvar S, Zhou Y, Epstein G, Hedayat S, Nikolic D, Krause EC, Piersen CE, Bolton JL, Pauli GF, Farnsworth NR., Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial., Menopause. 2009 Nov-Dec;16(6):1156-66. Pubmed
  30. Calderón AI, Wright BJ, Hurst WJ, van Breemen RB., Screening antioxidants using LC-MS: case study with cocoa., J Agric Food Chem. 2009 Jul 8;57(13):5693-9. Pubmed
  31. Gödecke T, Lankin DC, Nikolic D, Chen SN, van Breemen RB, Farnsworth NR, Pauli GF., Guanidine Alkaloids and Pictet-Spengler Adducts from Black Cohosh (Cimicifuga racemosa) (dagger)., J Nat Prod. 2009 Mar;72(3):433-7. Pubmed
  32. Wang Z, Wijewickrama GT, Peng KW, Dietz BM, Yuan L, van Breemen RB, Bolton JL, Thatcher GR., Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus., J Biol Chem. 2009 Mar 27;284(13):8633-42. Epub 2009 Jan 21. Pubmed
  33. Gödecke T, Nikolic D, Lankin DC, Chen SN, Powell SL, Dietz B, Bolton JL, van Breemen RB, Farnsworth NR, Pauli GF., Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts., Phytochem Anal. 2009 Mar;20(2):120-33. Pubmed
  34. Powell SL, Gödecke T, Nikolic D, Chen SN, Ahn S, Dietz B, Farnsworth NR, van Breemen RB, Lankin DC, Pauli GF, Bolton JL., In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent. J Agric Food Chem. 2008 Dec 24;56(24):11718-26. Pubmed
  35. Qin Z, Kastrati I, Ashgodom RT, Lantvit DD, Overk CR, Choi Y, van Breemen RB, Bolton JL, Thatcher GR., Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators. Drug Metab Dispos. 2009 Jan;37(1):161-9. Epub 2008 Oct 20. Pubmed
  36. Dietz BM, Liu D, Hagos GK, Yao P, Schinkovitz A, Pro SM, Deng S, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL., Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1., Chem Res Toxicol. 2008 Oct;21(10):1939-48. Epub 2008 Sep 23. Pubmed
  37. Ding S, Wang Y, Kolbanovskiy A, Durandin A, Bolton JL, van Breemen RB, Broyde S, Geacintov NE., Determination of absolute configurations of 4-hydroxyequilenin-cytosine and -adenine adducts by optical rotatory dispersion, electronic circular dichroism, density functional theory calculations, and mass spectrometry., Chem Res Toxicol. 2008 Sep;21(9):1739-48. Epub 2008 Aug 5. Pubmed
  38. Guo J, Liu A, Cao H, Luo Y, Pezzuto JM, van Breemen RB., Biotransformation of the chemopreventive agent 2',4',4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases., Drug Metab Dispos. 2008 Oct;36(10):2104-12. Epub 2008 Jul 24. Pubmed
  39. Overk CR, Guo J, Chadwick LR, Lantvit DD, Minassi A, Appendino G, Chen SN, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL., In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin., Chem Biol Interact. 2008 Oct 22;176(1):30-9. Epub 2008 Jun 20. Pubmed
  40. van Breemen RB, Pajkovic N., Multitargeted therapy of cancer by lycopene., Cancer Lett. 2008 Oct 8;269(2):339-51. Epub 2008 Jun 27. Review. Pubmed
  41. van Breemen RB, Fong HH, Farnsworth NR., Ensuring the safety of botanical dietary supplements. Am J Clin Nutr. 2008 Feb;87(2):509S-13S. Pubmed
  42. Farnsworth NR, Krause EC, Bolton JL, Pauli GF, van Breemen RB, Graham JG., The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical use. Am J Clin Nutr. 2008 Feb;87(2):504S-8S. Pubmed
  43. Barnes S, Birt DF, Cassileth BR, Cefalu WT, Chilton FH, Farnsworth NR, Raskin I, van Breemen RB, Weaver CM. Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers. Am J Clin Nutr. 2008 Feb;87(2):476S-80S. PubMed
  44. Farnsworth NR, Krause EC, van Breemen RB, Graham JG. UIC / NIH Center for Botanical Dietary Supplements Research – translational research: from plant to clinical use. Am J Clin Nutr. 2008 Feb;87(2):504S-8S. PubMed
  45. van Breemen RB, Fong HHS, Farnsworth NR. Ensuring the safety of botanical dietary supplements. Am J Clin Nutr. 2008Feb;87(2):509S-13S. PubMed
  46. Choi Y, van Breemen RB. Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS. Comb Chem High Throughput Screen. 2008 Jan;11(1):1-6. PubMed
  47. Cao H, Xiao L, Park G, Wang X, Azim AC, Christman JW, van Breemen RB. Abstract An improved LC-MS/MS method for the quantification of prostaglandins E(2) and D(2) production in biological fluids. Anal Biochem. 2008 Jan 1;372(1):41-51. Epub 2007 Sep 29. PubMed
  48. Galbiati F, Basso V, Cantuti L, Givogri MI, Lopez-Rosas A, Perez N, Vasu C, Cao H, van Breemen R, Mondino A, Bongarzone ER. Autonomic denervation of lymphoid organs leads to epigenetic immune atrophy in a mouse model of Krabbe disease. J Neurosci. 2007 Dec 12;27(50):13730-8. PubMed
  49. Liu D, Guo J, Luo Y, Broderick DJ, Schimerlik MI, Pezzuto JM, van Breemen RB. Screening for ligands of human retinoid X receptor-α using ultrafiltration mass spectrometry. Anal. Chem. 2007 Nov 13 eprint. PubMed
  50. Azim AC, Wang X, Park GY, Sadikot RT, Cao H, Mathew B, Atchison M, van Breemen RB, Joo M, Christman JW. NF-{kappa}B-Inducing Kinase Regulates Cyclooxygenase 2 Gene Expression in Macrophages by Phosphorylation of PU.1. J Immunol. 2007 Dec 1;179(11):7868-75. PubMed
  51. Guo J, Liu D, Nikolic D, Zhu D, Pezzuto JM, van Breemen RB. Free Full Text In vitro metabolism of isoliquiritigenin by human liver microsomes. Drug Metab Dispos. 2007 Nov 15; [Epub ahead of print] PubMed
  52. Luo Y, Eggler AL, Liu D, Liu G, Mesecar AD, van Breemen RB. Sites of Alkylation of Human Keap1 by Natural Chemoprevention Agents. J Am Soc Mass Spectrom. 2007 Oct 2; [Epub ahead of print] PubMed
  53. Eggler AL, Luo Y, van Breemen RB, Mesecar AD. Identification of the Highly Reactive Cysteine 151 in the Chemopreventive Agent-Sensor Keap1 Protein is Method-Dependent. Chem Res Toxicol. 2007 Oct 13; [Epub ahead of print]. PubMed
  54. Pang Y, Nikolic D, Zhu D, Chadwick LR, Pauli GF, Farnsworth NR, van Breemen RB. Binding of the hop (Humulus lupulus L.) chalcone xanthohumol to cytosolic proteins in Caco-2 intestinal epithelial cells. Mol Nutr Food Res. 2007, 51, 872-879. PubMed
  55. Goo YA, Li Z, Pajkovic N, Shaffer S, Taylor G, Chen J, Campbell D, Arnstein L, Goodlett DR, van Breemen RB. Systematic investigation of lycopene effects in LNCaP cells by use of novel large-scale proteomic analysis software. Proteomics Clin. Appl. 2007 1, 513-523.
  56. Azim AC, Cao H, Gao X, Joo M, Malik AB, van Breemen RB, Sadikot RT, Park G, Christman JW. Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages. Am J Physiol Lung Cell Mol Physiol. 2007, 293, L668-673. PubMed
  57. Chen SN, Lankin DC, Nikolic D, Fabricant DS, Lu ZZ, Ramirez B, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. Chlorination diversifies Cimicifuga racemosa triterpene glycosides. J Nat Prod. 2007, 70, 1016-1023. PubMed
  58. van Breemen RB, Fong HH, Farnsworth NR. The role of quality assurance and standardization in the safety of botanical dietary supplements. Chem Res Toxicol. 2007, 20, 577-582. Review. PubMed
  59. Li W, Xu X, Zhang H, Ma C, Fong H, van Breemen R, Fitzloff J. Secondary metabolites from Andrographis paniculata. Chem Pharm Bull (Tokyo). 2007, 55, 455-458. PubMed
  60. Turner A, Chen SN, Nikolic D, van Breemen R, Farnsworth NR, Pauli GF. Coumaroyl iridoids and a depside from cranberry (Vaccinium macrocarpon). J Nat Prod. 2007, 70, 253-258. PubMed
  61. Mathew B, Park GY, Cao H, Azim AC, Wang X, van Breemen RB, Sadikot RT, Christman JW. Inhibitory Kappa B Kinase 2 Activates Airway Epithelial Cells to Stimulate Bone Marrow Macrophages. Am. J. Respir. Cell Mol. Biol. 2007, 36, 562-572. PubMed
  62. Deng S, Chen SN, Lu J, Wang ZJ, Nikolic D, van Breemen RB, Santarsiero BD, Mesecar A, Fong HH, Farnsworth NR, Pauli GF. GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels. Phytochem. Anal. 2006, 17, 398-405. PubMed
  63. Wang Z, Yuan H, Nikolic D, van Breemen RB, Silverman RB. (+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway. Biochemistry 2006, 45, 14513-14522. PubMed
  64. Liu A, Pajkovic N, Pang Y, Zhu D, Calamini B, Mesecar A, van Breemen RB. Absorption and subcellular localization of lycopene in human prostate cancer cells. Mol. Cancer Ther. 2006, 5, 2879-2885. PubMed
  65. Melse-Boonstra A, Verhoef P, West CE, van Rhijn JA, van Breemen RB, Lasaroms JJ, Garbis SD, Katan MB, Kok FJ. A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses. Am. J. Clin. Nutr. 2006, 84, 1128-1133. PubMed
  66. Kapetanovic IM, Krishnaraj R, Martin-Jimenez T, Yuan L, van Breemen RB, Lyubimov A. Effects of oral dosing paradigms (gavage versus diet) on pharmacokinetics and pharmacodynamics. Chem. Biol. Interact. 2006, 164, 68-75. PubMed
  67. Zhu D, Wang Y, Pang Y, Liu A, Guo J, Bouwman CA, West CE, van Breemen RB. Quantitative analyses of beta-carotene and retinol in serum and feces in support of clinical bioavailability studies. Rapid Commun. Mass Spectrom. 2006, 20, 2427-2432. PubMed
  68. Nikolic D, Li Y, Chadwick LR, van Breemen RB. In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.). Pharm. Res. 2006, 23, 864-872. PubMed
  69. Mallavadhani UV, Narasimhan K, Sudhakar AV, Mahapatra A, Li W, van Breemen RB. Three new pentacyclic triterpenes and some flavonoids from the fruits of an Indian Ayurvedic plant Dendrophthoe falcata and their estrogen receptor binding activity. Chem. Pharm. Bull (Tokyo) 2006, 54, 740-744. PubMed
  70. Deng S, Chen SN, Yao P, Nikolic D, van Breemen RB, Bolton JL, Fong HH, Farnsworth NR, Pauli GF. Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. J. Nat. Prod. 2006, 69, 536-541. PubMed
  71. Guo J, Nikolic D, Chadwick LR, Pauli GF, van Breemen RB. Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.). Drug Metab. Dispos. 2006, 34, 1152-1159. PubMed
  72. Booth NL, Overk CR, Yao P, Burdette JE, Nikolic D, Chen SN, Bolton JL, van Breemen RB, Pauli GF, Farnsworth NR. The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract. J. Altern. Complement Med. 2006, 12, 133-139. PubMed
  73. van Breemen RB, Li Y. Caco-2 cell permeability assays to measure drug absorption. Expert Opin. Drug Meta.b Toxicol. 2005, 1, 175-185. PubMed
  74. van Breemen RB. How do intermediate endpoint markers respond to lycopene in men with prostate cancer or benign prostate hyperplasia? J.Nutr. 2005, 135, 2062S-4S. PubMed
  75. Cheng X and van Breemen RB. Mass spectrometry-based screening for inhibitors of beta-amyloid protein aggregation. Anal.Chem. 2005, 77, 7012-7015. PubMed
  76. Li Y, Yang X, Chang M, Yager JD, van Breemen RB, Bolton JL. Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferase. Chem. Biol. Interact. 2005 152, 151-163 (2005).
  77. Chow AW, Murillo G, Yu C, van Breemen RB, Boddie AW, Pezzuto JM, Das Gupta TK and Mehta RG. Resveratrol inhibits rhabdomyosarcoma cell proliferation. Eur.J.Cancer Prev. 2005, 14, 351-356. PubMed
  78. Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB and Bolton JL. Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase. Chem.Res.Toxicol. 2005,18, 1296-1305. PubMed
  79. Eggler AL, Liu G, Pezzuto JM, van Breemen RB and Mesecar AD. Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc.Natl.Acad.Sci.U.S.A. 2005, 102, 10070-10075. PubMed
  80. Fabricant DS, Nikolic D, Lankin DC, Chen SN, Jaki BU, Krunic A, van Breemen RB, Fong HH, Farnsworth NR and Pauli GF. Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa. J.Nat.Prod. 2005, 68, 1266-1270. PubMed
  81. Li Y, Yang X, van Breemen RB and Bolton JL. Characterization of two new variants of human catechol O-methyltransferase in vitro. Cancer Lett.2005, 230, 81-89. PubMed
  82. Liu G, Eggler AL, Dietz BM, Mesecar AD, Bolton JL, Pezzuto JM and van Breemen RB. Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. Anal.Chem. 2005, 77, 6407-6414. PubMed
  83. Liu H, Liu J, van Breemen RB, Thatcher GR and Bolton JL. Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation. Chem.Res.Toxicol. 2005, 18, 162-173. PubMed
  84. Liu J, Li Q, Yang X, van Breemen RB, Bolton JL and Thatcher GR. Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study. Chem.Res.Toxicol. 2005, 18, 1485-1496. PubMed
  85. Liu J, Liu H, van Breemen RB, Thatcher GR and Bolton JL. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides. Chem.Res.Toxicol. 2005, 18, 174-182. PubMed
  86. Overk CR, Yao P, Chadwick LR, Nikolic D, Sun Y, Cuendet MA, Deng Y, Hedayat AS, Pauli GF, Farnsworth NR, van Breemen RB and Bolton JL. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). J.Agric.Food Chem. 2005, 53, 6246-6253. PubMed. *This paper was cited by the NIH in the Annual Bibliography of Significant Advances in Dietary Supplement Research, 2005. Ed. by RB Costello and LG Saldanha. NIH Publication No. 06-6060, September 2006.
  87. Sun Y, Li W, Fitzloff JF, van Breemen RB. Liquid chromatography/electrospray tandem mass spectrometry of terpenoid lactones in Ginkgo biloba. J. Mass Specrom. 2005, 40, 373-379. PubMed
  88. Constantinou AI, White BEP, Tonetti D, Yang Y, Liang W, Li W, van Breemen RB. The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours. Eur. J. Cancer. 2005, 41, 647-654. PubMed
  89. Kobayashi T, Yang X, Walker LA, van Breemen RB, Solaro RJ. A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: Identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C. J. Mol. Cell. Cardiol. 2005, 38, 213-218. PubMed
  90. Zhu Y, Nikolic D, van Breemen, RB, Silverman RB. Mechanism of inactivation of inducible nitric oxide synthase by amidines Irreversible enzyme inactivation without inactivator modification. J. Am. Chem. Soc. 2005, 127, 858-868. PubMed
  91. Sun Y, Gu C, Liu X, Liang W, Yao P, Bolton JL, van Breemen RB. Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors. J. Am. Soc. Mass Spectrom. 2005, 16, 271-279. PubMed
  92. Nikolic D, Li Y, Chadwick LR, Pauli GF, van Breemen RB. Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes. J. Mass Spectrom. 2005, 40, 289-299. PubMed
  93. Singletary KW, Barnes SL, van Breemen RB. Ethanol inhibits benzo[a]pyrene-DNA adduct removal and increases 8-oxo-deoxyguanosine formation in human mammary epithelial cells. Cancer Lett. 2004, 203, 139-144. PubMed
  94. Nikolic D, Li Y, Chadwick LR, Grubjesic S, Schwab P, Metz P, van Breemen RB. Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes. Drug. Metab. Dispos. 2004, 32, 272-279. PubMed.
  95. Yang X, Wu H, Kobayashi T, Solaro RJ, Van Breemen RB. Enhanced Ionization of Phosphorylated Peptides during MALDI TOF Mass Spectrometry. Anal. Chem. 2004, 76, 1532-6. PubMed
  96. Liu J, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR. Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry). Phytomedicine. 2004, 11, 18-23. PubMed
  97. Nikolic D, van Breemen RB. New metabolic pathways for flavanones catalyzed by rat liver microsomes. Drug Metab. Dispos. 2004, 32, 387-397. PubMed
  98. Li Y, Yao J, Chang M, Nikolic D, Yu L, Yager JD, Mesecar AD, van Breemen RB, Bolton JL. Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase. Chem. Res. Toxicol. 2004, 17, 512-520. PubMed
  99. Piersen CE, Booth NL, Sun Y, Liang W, Burdette JE, van Breemen RB, Geller SE, Gu C, Banuvar S, Shulman LP, Bolton JL, Farnsworth NR. Chemical and biological characterization and clinical evaluation of botanical dietary supplements: a phase I red clover extract as a model. Cur. Med. Chem. 2004, 11, 1361-1374. PubMed
  100. Yu L, Liu H, Li W, Zhang F, Luckie C, van Breemen RB, Thatcher RJ, Bolton JL. Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones. Chem. Res. Toxicol. 2004, 17, 879-888. PubMed
  101. Li Y, Grubjesic S, Nikolic D, Zhu D, Kosmeder J, Moriarty RM, Pezzuto JM, van Breemen RB. In vitro assessment of intestinal permeability and hepatic metabolism of 4’-bromoflavone, a promising cancer chemopreventive agent. Xenobiotica, 2004, 34, 535-547. PubMed
  102. Li W, Sun Y, van Breemen RB, Fitzloff JF. Evaluation of major caffeic acid derivatives in Echinacea purpurea dietary supplements by HPLC with photodiode array detection and electrospray mass spectrometry. J. Liq. Chromatogr. Rel. Technol. 2004, 27, 2507-2529.
  103. Booth NL, Nikolic D, van Breemen RB, Geller SE, Banuvar S, Shulman LP, Farnsworth NR. Confusion regarding anticoagulant coumarins in dietary supplements. Clin. Pharmacol. Therapeut. 2004, 76, 511-516. PubMed
  104. Mariappan SV, Cheng X, van Breemen RB, Silks LA, Gupta G. Analysis of GAA/TTC DNA triplexes using nuclear magnetic resonance and electrospray ionization mass spectrometry. Anal. Biochem. 2004, 334, 216-226. PubMed
  105. Chadwick LR, Nikolic D, Burdette JE, Overk CR, Bolton JL, van Breemen RB, Frohlich R, Fong HHS, Farnsworth NR, Pauli GF. Estrogens and congeners from spent hops (Humulus lupulus). J. Nat. Prod. 2004, 67, 2024-2032. PubMed
  106. van Lieshout M, West CE, van Breemen RB. Isotopic tracer techniques for studying the bioavailability and bioefficacy of dietary carotenoids, particularly beta-carotene, in humans: a review. Am. J. Clin. Nutr. 2003, 77, 12-28 . PubMed
  107. Su B-N, Cuendet M, Nikolic D, Kristinsson H, Ingolfsdottir K, van Breemen RB, Fong HHS, Pezzuto JM, Kinghorn AD. NMR study of fumarprotocetraric acid, a complex lichen depsidone derivative from Cladonia furcata. Magn. Reson. Chem.2003, 41, 391-394 .PubMed
  108. Gu J-Q, Li W, Kang Y-H, Su B-N, Fong HHS, van Breemen RB, Pezzuto JM, Kinghorn AD. Minor withanolides from Physalis philadelphica: Structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation of artifacts. Chem. Pharm. Bull. (Tokyo), 2003, 51, 530-539. PubMed
  109. Li W, Sun Y, Liang W, Fitzloff JF, van Breemen RB. Identification of caffeic acid derivatives in Actea racemosa (Cimicifuga racemosa, black cohosh) by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2003, 17, 978-982. PubMed
  110. Johnson BM, Qiu S-X, Zhang S, Zhang F, Burdette JE, Yu L, Bolton JL, van Breemen RB. Identification of novel electrophilic mammalian metabolites of Piper methysticum Forst. (Kava). Chem. Res. Toxicol. 2003, 16, 733-740. PubMed
  111. Liu X, Zhang F, Liu H, Burdett JE, Li Y, Overk CR, Pisha E, Yao J, van Breemen RB, Swanson SM, Bolton JL. Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin. Chem. Res Toxicol. 2003, 16, 741-749. PubMed
  112. Kouloumbos VN, Tsipi DF, Hiskia AE, Nikolic D, van Breemen RB. Identification of photocatalytic degradation products of diazinon in TiO2 aqueous suspensions using GC/MS/MS and LC/MS with quadrupole time-of-flight mass spectrometry. J. Am. Soc. Mass Spectrom. 2003, 14, 803-817. PubMed
  113. Su B-N, Park EJ, Nikolic D, Vigo JS, Graham JG, Cabieses F, van Breemen RB, Fong HHS, Farnsworth NR, Pezzuto JP, Kinghorn AD. Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora. J. Nat. Prod. 2003, 66, 1089-1093. PubMed
  114. Cheng X, Shin YG, Levine BS, Smith AC, Tomaszewski JE, van Breemen RB. Quantitative analysis of betulinic acid in mouse, rat and dog plasma using electrospray LC-MS. Rap. Commun. Mass Spectrom. 2003, 17, 2089-2092. PubMed
  115. Johnson BM, van Breemen RB. In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh). Chem. Res. Toxicol. 2003, 16, 838-846. PubMed
  116. van Lieshout M, West CE, van de Bovenkamp P, Wang Y, Sun Y, van Breemen RB, Muhilal DP, Verhoeven MA, Creemers AFL, Lugtenburg J. Extraction of carotenoids from feces, enabling the bioavailability of b-carotene to be studied in Indonesian children. J. Agric. Food Chem. 2003, 51, 5123-5130. PubMed
  117. Burdette JE, Liu J, Chen S-N, Fabricant DS, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, van Breemen RB, Farnsworth NR, Bolton JL. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.J. Agric. Food Chem. 2003, 51, 5661-5670. PubMed
  118. Lyons MM, Yu C, Toma RB, Cho SY, Reiboldt W, Lee J, van Breemen RB. Resveratrol in raw and baked blueberries and bilberries. J. Agric. Food Chem. 2003, 51, 5867-5870. PubMed
  119. Lu X, Nikolic D, Mitchell DJ, van Breemen RB, Mersfelder JA, Hille R, Silverman RB. A mechanism for substrate-induced formation of 6-hydroxyflavin mononucleotide catalyzed by C30A trimethylamine dehydrogenase. Bioorg. Med. Chem. Lett.2003, 13, 4129-4132. PubMed
  120. Singletary KW, Stansbury MJ, Giusti M, Van Breemen RB, Wallig M, Rimando A. Inhibition of rat mammary tumorigenesis by concord grape juice constituents. J. Agric. Food Chem. 2003, 51, 7280-7286. PubMed
  121. Li Y, Shin YG, Yu C, Kosmeder JW, Hirschelman WH, Pezzuto JM, van Breemen RB. Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: Application to resveratrol absorption and metabolism. Comb. Chem. High Throughput Screen.2003, 6, 757-767. PubMed
  122. Yao J, Li Y, Chang M, Wu H, Yang X, Goodman JE, Liu X, Liu H, Mesecar AD, van Breemen RB, Yager JD, Bolton JL. Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase. Chem. Res. Toxicol. 2003, 16, 668-675. PubMed
  123. Yu,C.; Shin,Y.G.; Kosmeder,J.W.; Pezzuto,J.M.; van Breemen,R.B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Communications in Mass Spectrometry 2003, 17, 307-313. PubMed
  124. Su B-N, Park EJ, Nikolic D, Santarsiero BD, Mesecar AD, Vigo JS, Graham JG, Cabieses F, van Breemen RB, Fong HSS, Farnsworth NR, Pezzuto JM, Kinghorn AD. Activity-guided isolation of novel norwithanolides from Deprea subtriflora with potential cancer chemopreventive activity. J. Org. Chem. 2003 68, 2350-2361 PubMed
  125. Fang,L.; Pajkovic,N.; Wang,Y.; Gu,C.; van Breemen,R.B. Quantitative analysis of lycopene isomers in human plasma using high-performance liquid chromatography-tandem mass spectrometry. Analytical Chemistry 2003, 75, 812-817. PubMed
  126. Li,W.; Sun,Y.; Joseph,J.; Fitzloff,J.F.; Fong,H.H.S.; van Breemen,R.B. p-Hydroxybenzoic Acid Alkyl Esters in Andrographis paniculata Herbs, Commercial Extracts, and Formulated Products. Journal of Agricultural and Food Chemistry 2002, 51, 524-529. PubMed
  127. Yu, C.; Shin,Y.G.; Chow,A.; Li,Y.; Kosmeder,J.W.; Lee,Y.S.; Hirschelman,W.H.; Pezzuto,J.M.; Mehta,R.G.; van Breemen,R.B. Human, Rat, and Mouse Metabolism of Resveratrol. Pharmaceutical Research 2002, 19, 1907-1914. PubMed
  128. Johnson,B.M.; Nikolic,D.; van Breemen,R.B. Application of pulsed ultrafiltration-mass spectrometry. Mass Spectrometry Reviews 2002, 21, 76-86. PubMed
  129. Bowen,P.; Chen,L.; Stacewicz-Sapuntzakis,M.; Duncan,C.; Sharifi,R.; Ghosh,L.; Kim,H.S.; Christov-Tzelkov,K.; Van Breemen,R. Tomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis. Experimental Biology and Medicine (Maywood, NJ, United States) 2002, 227, 886-893. PubMed
  130. Burdette,J.E.; Chen,S.n.; Lu,Z.Z.; Xu,H.; White,B.E.P.; Fabricant,D.S.; Liu,J.; Fong,H.H.S.; Farnsworth,N.R.; Constantinou,A.I.; van Breemen,R.B.; Pezzuto,J.M.; Bolton,J.L. Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: Bioassay-directed isolation and characterization of active principles. Journal of Agricultural and Food Chemistry 2002, 50, 7022-7028. PubMed
  131. van Breemen, RB, Bolton JL, Johnson BM. Rapid in vitro screening of botanical dietary supplements and pharmaceuticals for metabolic activation to electrophilic metabolites: Validation by detection of corresponding mercapturates in urine. Drug Metab. Rev. 2002 34: 394 Suppl. 1.
  132. Yang,Y.; Nikolic,D.; Swanson,S.M.; van Breemen,R.B. Quantitative determination of N7-methyldeoxyguanosine and O6-methyldeoxyguanosine in DNA by LC-UV-MS-MS. Analytical Chemistry 2002, 74, 5376-5382. PubMed
  133. Li,W.; Sun,Y.; Fitzloff,J.F.; van Breemen,R.B. Evaluation of Commercial Ginkgo and Echinacea Dietary Supplements for Colchicine Using Liquid Chromatography-Tandem Mass Spectrometry. Chemical Research in Toxicology 2002, 15, 1174-1178. PubMed
  134. Prins,G.S.; Chang,W.Y.; Wang,Y.; van Breemen,R.B. Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure. Endocrinology 2002, 143, 3628-3640. PubMed
  135. Wang,Y.; Catana,F.; Yang,Y.; Roderick,R.; van Breemen,R.B. An LC-MS Method for Analyzing Total Resveratrol in Grape Juice, Cranberry Juice, and in Wine. Journal of Agricultural and Food Chemistry 2002, 50, 431-435. Pubmed
  136. Papadantonakis,G.A.; Tranter,R.; Brezinsky,K.; Yang,Y.; van Breemen,R.B.; LeBreton,P.R. Low-Energy, Low-Yield Photoionization, and Production of 8-Oxo-2'-deoxyguanosine and Guanine from 2'-Deoxyguanosine. Journal of Physical Chemistry B 2002, 106, 7704-7712. Abstract
  137. Constantinou,A.I.; Lucas,L.M.; Lantvit,D.; Hawthorne,M.; Xu,X.; Nho,C.W.; Jeffery,E.H.; Christov,K.; van Breemen,R.B.; Pezzuto,J.M. Soy protein isolate prevents chemically-induced rat mammary tumors. Pharmaceutical Biology (Lisse, Netherlands) 2002, 40, 24-34.
  138. Liu,X.; Yao,J.; Pisha,E.; Yang,Y.; Hua,Y.; van Breemen,R.B.; Bolton,J.L. Oxidative DNA Damage Induced by Equine Estrogen Metabolites: Role of Estrogen Receptor a. Chemical Research in Toxicology 2002, 15, 512-519. PubMed
  139. Shin,Y.G.; Bolton,J.L.; van Breemen,R.B. Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry. Combinatorial Chemistry and High Throughput Screening 2002, 5, 59-64. PubMed
  140. Burdette,J.E.; Liu,J.; Lantvit,D.; Lim,E.; Booth,N.; Bhat,K.P.L.; Hedayat,S.; van Breemen,R.B.; Constantinou,A.I.; Pezzuto,J.M.; Farnsworth,N.R.; Bolton,J.L. Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats. Journal of Nutrition 2002, 132, 27-30. PubMed
  141. van Breemen,R.B.; Xu,X.; Viana,M.A.; Chen,L.; Stacewicz-Sapuntzakis,M.; Duncan,C.; Bowen,P.E.; Sharifi,R. Liquid Chromatography-Mass Spectrometry of cis- and all-trans-Lycopene in Human Serum and Prostate Tissue after Dietary Supplementation with Tomato Sauce. Journal of Agricultural and Food Chemistry 2002, 50, 2214-2219. PubMed
  142. Shin,Y.G.; van Breemen,R.B. Analysis and screening of combinatorial libraries using mass spectrometry. Biopharmaceutics & Drug Disposition 2001, 22, 353-372. PubMed
  143. Constantinou,A.I.; Lantvit,D.; Hawthorne,M.; Xu,X.; van Breemen,R.B.; Pezzuto,J.M. Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats. Nutrition and Cancer 2001, 41, 75-81. PubMed
  144. Zhang F, Swanson SM, van Breemen RB, Liu X, Yang Y, Gu C, Bolton JL. Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: Formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases. Chem. Res. Toxicol. 2001 14, 1654-9. PubMed
  145. Yao,D.; Zhang,F.; Yu,L.; Yang,Y.; van Breemen,R.B.; Bolton,J.L. Synthesis and Reactivity of Potential Toxic Metabolites of Tamoxifen Analogues: Droloxifene and Toremifene o-Quinones. Chemical Research in Toxicology 2001, 14, 1643-1653. PubMed
  146. Mitchell DJ, Nikolic D, van Breemen RB, Silverman RB. Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: Mass spectral evidence for the flavin adduct. Bioorg. Med. Chem. Lett. 2001 11, 1757-1760.
  147. Mitchell DJ, Nikolic D, Jang MH, van Breemen RB, Hille R, Silverman RB. Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-alpha-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine. Biochemistry, 2001 40, 8523-30.
  148. van Lieshout M, West CE, Muhilal, Permaesih D, Wang Y, Xu X, van Breemen RB, Creemers AF, Verhoeven MA, Lugtenburg J. Bioefficacy of beta-carotene dissolved in oil studied in children in Indonesia. Am. J. Clin. Nutr. 2001 73, 949-58.
  149. Mitchell DJ, Nikolic D, Rivera E, Sablin SO, Choi S, van Breemen RB, Singer TP, Silverman, RB. Spectrometric evidence for the flavin-1-phenylcyclopropylamine inactivator adduct with monoamine oxidase N. Biochemistry, 2001 40, 5447-56.
  150. Garbis SD, Melse-Boonstra A, West CE, van Breemen RB. Determination of folates in human plasma using hydrophilic interaction chromatography-tandem mass spectrometry. Anal. Chem. 2001 73, 5358-5364. PubMed
  151. Johnson,B.M.; Bolton,J.L.; van Breemen,R.B. Screening Botanical Extracts for Quinoid Metabolites. Chemical Research in Toxicology 2001, 14 , 1546-1551. PubMed
  152. Wang,Y.; Chang,W.Y.; Prins,G.S.; van Breemen,R.B. Simultaneous determination of all-trans, 9-cis, 13-cis retinoic acid and retinol in rat prostate using liquid chromatography-mass spectrometry. Journal of Mass Spectrometry 2001, 36, 882-888. PubMed
  153. Zhang,F.; Yao,D.; Hua,Y.; van Breemen,R.B.; Bolton,J.L. Synthesis and reactivity of catechol metabolites from equine estrogen 8,9-dehydroestrone. Chemical Research in Toxicology 2001, 14, 754-763. PubMed
  154. Park,E.J.; Lee,D.; Shin,Y.G.; Lantvit,D.D.; van Breemen,R.B.; Kinghorn,A.D.; Pezzuto,J.M. Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry. Journal of Chromatography, B: Biomedical Sciences and Applications 2001, 754, 327-332. PubMed
  155. Liu,J.; Burdette,J.E.; Xu,H.; Gu,C.; van Breemen,R.B.; Bhat,K.P.L.; Booth,N.; Constantinou,A.I.; Pezzuto,J.M.; Fong,H.H.S.; Farnsworth,N.R.; Bolton,J.L. Evaluation of Estrogenic Activity of Plant Extracts for the Potential Treatment of Menopausal Symptoms. Journal of Agricultural and Food Chemistry 2001, 49, 2472-2479.
  156. Chang, M.; Shin, Y.-G.; van Breemen, R. B.; Blond, S. Y.; Bolton, J. L. Structural and functional consequences of inactivation of human glutathione S-transferase P1-1 mediated by the catechol metabolite of equine estrogens, 4-hydroxyequilenin. Biochemistry, 2001 40, 4811-4820.
  157. Wang Y, Chang WY, Prins GS, van Breemen RB. Simultaneous determination of all-trans, 9-cis, 13-cis retinoic acid and retinol in rat prostate using liquid chromatography-mass spectrometry. J. Mass Spectrom. 2001 36, 882-888.
  158. Nikolic D, van Breemen RB. DNA Oxidation induced by cyclooxygenase-2. Chem. Res. Toxicol. 2001 14, 351-354.
  159. Nikolic,D.; van Breemen,R.B. DNA Oxidation Induced by Cyclooxygenase-2. Chemical Research in Toxicology 2001, 14, 351-354.
  160. Hua,Y.; Wainhaus,S.B.; Yang,Y.; Shen,L.; Xiong,Y.; Xu,X.; Zhang,F.; Bolton,J.L.; van Breemen,R.B. Comparison of negative and positive ion electrospray tandem mass spectrometry for the liquid chromatography tandem mass spectrometry analysis of oxidized deoxynucleosides. Journal of the American Society for Mass Spectrometry 2001, 12, 80-87.
  161. Hamm, M. L.; Nikolic, D.; van Breemen, R. B.; Piccirilli, J. A. Unconventional origin of metal ion rescue in the hammerhead ribozyme reaction: Mn2+-assisted redox conversion of 2’-mercaptocytidine to cytidine. J. Am. Chem. Soc. 2000 122, 12069-12078.
  162. Li, W.; Gu, C.; Zhang, H.; Awang, D. V. C.; Fitzloff, J. F.; Fong, H. H. S.; van Breemen, R. B. Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C. A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng). Anal. Chem. 2000 72, 5417-5422.
  163. Nikolic,D.; Habibi-Goudarzi,S.; Corley,D.G.; Gafner,S.; Pezzuto,J.M.; van Breemen,R.B. Evaluation of Cyclooxygenase-2 Inhibitors Using Pulsed Ultrafiltration Mass Spectrometry. Analytical Chemistry 2000, 72, 3853-3859.
  164. Wang, Y.; Xu, X.; van Lieshout, M.; West, C. E.; Lugtenburg, J.; Verhoeven, M. A.; Creemers, A. F. L.; Muhilal; van Breemen, R. B. A liquid chromatography-mass spectrometry method for the quantification of bioavailability and bioconversion of  b-carotene to retinol in humans. Anal. Chem. 2000 72, 4999-5003.
  165. Henry, L. K.; Puspitasari-Nienaber, N. L.; Jarén-Galán, M.; van Breemen, R. B.; Catignani, G.; Schwartz, S. J. Effects of ozone and oxygen on the degradation of carotenoids in an aqueous model system. J. Agric. Food Chem. 2000 48, 5008-5013.
  166. Westenburg, H. E.; Lee, K.-J.; Lee, S. K; Fong, H. H.; van Breemen, R. B.; Pezzuto, J. M.; Kinghorn, A. D. Activity-guided isolation of antioxidative constituents of Cotinus coggygria. J. Nat. Prod. 2000 63, 1696-1698.
  167. Chen,Y.; Liu,X.; Pisha,E.; Constantinou,A.I.; Hua,Y.; Shen,L.; van Breemen,R.B.; Elguindi,E.C.; Blond,S.Y.; Zhang,F.; Bolton,J.L. A Metabolite of Equine Estrogens, 4-Hydroxyequilenin, Induces DNA Damage and Apoptosis in Breast Cancer Cell Lines. Chemical Research in Toxicology 2000, 13, 342-350.
  168. Zhang,F.; Fan,P.W.; Liu,X.; Shen,L.; van Breemen,R.B.; Bolton,J.L. Synthesis and Reactivity of a Potential Carcinogenic Metabolite of Tamoxifen: 3,4-Dihydroxytamoxifen-o-quinone. Chemical Research in Toxicology 2000, 13, 53-62.
  169. Gu, C.; Nikolic, D.; Lai, J.; Xu, X.; van Breemen, R. B. Assays of ligand-human serum albumin binding using pulsed ultrafiltration and liquid chromatography-mass spectrometry. Comb. Chem. High Throughput Screen. 1999 2, 353-359.
  170. Fu, M.; Nikolic, D.; van Breemen, R. B.; Silverman, R. B. Mechanism of inactivation of g-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid. J. Am. Chem. Soc. 1999 121, 7751-7759.
  171. Xu,X.; Wang,Y.; Constantinou,A.I.; Stacewicz-Sapuntzakis,M.; Bowen,P.E.; van Breemen,R.B. Solubilization and stabilization of carotenoids using micelles: delivery of lycopene to cells in culture. Lipids 1999, 34, 1031-1036.
  172. Korecka, M.; Nikolic, D.; van Breemen, R. B.; Shaw, L. M. The apparent inhibition of inosine monophosphate dehydrogenase by mycophenolic acid glucuronide is attributable to the presence of trace quantities of mycophenolic acid. Clin.Chem. 1999 45, 1047-1059.
  173. Hadden, W. L.; Watkins, R. H.; Levy, L. W.; Regalado, E.; Rivadeneira, D. M.; van Breemen, R. B.; Schwartz, S. J. Carotenoid composition of marigold (Tagetes erecta) flower extract used as nutritional supplement. J. Agric. Food Chem. 1999 47, 4189-4194.
  174. Fast, W.; Nikolic, D.; van Breemen, R.; Marletta, M. A.; Silverman, R. B. Mechanistic Studies of the Inactivation of Inducible Nitric oxide synthase by N5-(1-iminoethyl)-L-ornithine (L-NIO). J. Am. Chem. Soc. 1999 121, 903-916.
  175. Nikolic,D.; Fan,P.W.; Bolton,J.L.; van Breemen,R.B. Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry. Combinatorial Chemistry and High Throughput Screening 1999, 2, 165-176.
  176. Zhang,F.; Chen,Y.; Pisha,E.; Shen,L.; Xiong,Y.; van Breemen,R.B.; Bolton,J.L. The Major Metabolite of Equilin, 4-Hydroxyequilin, Autoxidizes to an o-Quinone Which Isomerizes to the Potent Cytotoxin 4-Hydroxyequilenin-o-quinone. Chemical Research in Toxicology 1999, 12, 204-213.
  177. Chung,H.S.; Chang,L.C.; Lee,S.K.; Shamon,L.A.; van Breemen,R.B.; Mehta,R.G.; Farnsworth,N.R.; Pezzuto,J.M.; Kinghorn,A.D. Flavonoid Constituents of Chorizanthe diffusa with Potential Cancer Chemopreventive Activity. Journal of Agricultural and Food Chemistry 1999, 47, 36-41.
  178. Shaw, L. M.; Korecka, M.; van Breemen, R.; Nowak, I.; Brayman, K. L. Analysis, pharmacokinetics and therapeutic drug monitoring of mycophenolic acid. Clin. Biochem. 1998 31, 323-328.
  179. Ito,A.; Shamon,L.A.; Yu,B.; Mata-Greenwood,E.; Lee,S.K.; van Breemen,R.B.; Mehta,R.G.; Farnsworth,N.R.; Fong,H.H.S.; Pezzuto,J.M.; Kinghorn,A.D. Antimutagenic constituents of Casimiroa edulis with potential cancer chemopreventive activity. Journal of Agricultural and Food Chemistry 1998, 46, 3509-3516.
  180. Chen,Y.; Shen,L.; Zhang,F.; Lau,S.S.; van Breemen,R.B.; Nikolic,D.; Bolton,J.L. The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro. Chemical Research in Toxicology 1998, 11, 1105-1111.
  181. Chang,M.; Zhang,F.; Shen,L.; Pauss,N.; Alam,I.; van Breemen,R.B.; Blond,S.Y.; Bolton,J.L. Inhibition of Glutathione S-Transferase Activity by the Quinoid Metabolites of Equine Estrogens. Chemical Research in Toxicology 1998, 11, 758-765.
  182. van Breemen,R.B.; Tan,Y.; Lai,J.; Huang,C.R.; Zhao,X. Immobilized thymine chromatography-mass spectrometry of oligonucleotides. Journal of Chromatography, A 1998, 806, 67-76.
  183. Nikolic,D.; van Breemen,R.B. Screening for inhibitors of dihydrofolate reductase using pulsed ultrafiltration mass spectrometry. Combinatorial Chemistry and High Throughput Screening 1998, 1, 47-55.
  184. Shen,L.; Qiu,S.; Chen,Y.; Zhang,F.; van Breemen,R.B.; Nikolic,D.; Bolton,J.L. Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical. Chemical Research in Toxicology 1998, 11, 94-101.
  185. van Breemen,R.B.; Nikolic,D.; Bolton,J.L. Metabolic screening using online ultrafiltration mass spectrometry. Drug Metabolism and Disposition 1998, 26, 85-90.
  186. van Breemen,R.B.; Nikolic,D.; Xu,X.; Xiong,Y.; van Lieshout,M.; West,C.E.; Schilling,A.B. Development of a method for quantitation of retinol and retinyl palmitate in human serum using high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. Journal of Chromatography, A 1998, 794, 245-251.
  187. Bolton,J.L.; Pisha,E.; Shen,L.; Krol,E.S.; Iverson,S.L.; Huang,Z.; van Breemen,R.B.; Pezzuto,J.M. The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells. Chemico-Biological Interactions 1997, 106, 133-148.
  188. Zhang, H. Q.; Dixon, R. P.; Marletta, M. A.; Nikolic, D.; van Breemen, R.; Silverman, R. B. Mechanism of inactivation of neuronal nitric oxide synthase by N-allyl-L-arginine. J. Am. Chem. Soc. 1997 119, 10888-10902.
  189. Zhao,Y.Z.; van Breemen,R.B.; Nikolic,D.; Huang,C.R.; Woodbury,C.P.; Schilling,A.; Venton,D.L. Screening Solution-Phase Combinatorial Libraries Using Pulsed Ultrafiltration/Electrospray Mass Spectrometry. Journal of Medicinal Chemistry 1997, 40, 4006-4012.
  190. Shen,L.; Qiu,S.; van Breemen,R.B.; Zhang,F.; Chen,Y.; Bolton,J.L. Reaction of the Premarin Metabolite 4-Hydroxyequilenin Semiquinone Radical with 2'-Deoxyguanosine: Formation of Unusual Cyclic Adducts. Journal of the American Chemical Society 1997, 119, 11126-11127.
  191. van Breemen,R.B. Liquid chromatography/mass spectrometry of carotenoids. Pure and Applied Chemistry 1997, 69, 2061-2066.
  192. Shen,L.; Pisha,E.; Huang,Z.; Pezzuto,J.M.; Krol,E.; Alam,Z.; van Breemen,R.B.; Bolton,J.L. Bioreductive activation of catechol estrogen-ortho-quinones: Aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity. Carcinogenesis 1997, 18, 1093-1101.
  193. van Breemen,R.B.; Huang,C.R.; Nikolic,D.; Woodbury,C.P.; Zhao,Y.Z.; Venton,D.L. Pulsed Ultrafiltration Mass Spectrometry: A New Method for Screening Combinatorial Libraries. Analytical Chemistry 1997, 69, 2159-2164.
  194. van Breemen,R.B.; Huang,C.R.; Tan,Y.; Sander,L.C.; Schilling,A.B. Liquid chromatography/mass spectrometry of carotenoids using atmospheric pressure chemical ionization. Journal of Mass Spectrometry 1996, 31, 975-981.
  195. van Breemen,R.B.; Huang,C.R. High-performance liquid chromatography-electrospray mass spectrometry of retinoids. FASEB Journal 1996, 10, 1098-1101.
  196. van Breemen,R.B. Innovations in carotenoid analysis using LC/MS. Analytical Chemistry 1996, 68, 299A-304A. *This paper was featured on the cover page of this issue of Analytical Chemistry.
  197. van Breemen,R.B.; Huang,C.R.; Lu,Z.Z.; Rimando,A.; Fong,H.H.S.; Fitzloff,J.F. Electrospray Liquid Chromatography/Mass Spectrometry of Ginsenosides. Analytical Chemistry 1995, 67, 3985-3989.
  198. van Breemen,R.B. Electrospray Liquid Chromatography-Mass Spectrometry of Carotenoids. Analytical Chemistry 1995, 67, 2004-2009.
  199. Thomas, V. R.; Schreiner, A. F.; van Breemen, R.; Xie, T.-Y.; Chen, C.-L.; Gratzl, J. S., “Photolytic dechlorination of 4-chlorophenol using an ArF* excimer laser.” Holzforschung, 1995 49, 139-145.
  200. van Breemen, R. B. “Advances in carotenoid analysis: Electrospray liquid chromatography-mass spectrometry using C30 reversed phase HPLC.” Carotenoid News, 1995 5, 8-9.
  201. van Breemen,R.B.; Jian,O.; Tidwell,R.R.; Hall,J.E.; Brewer,T.G. Fast atom bombardment tandem mass spectrometry of the anti-parasitic agent pentamidine and its oxygenated metabolites. Journal of Mass Spectrometry 1995, 30, 549-556.
  202. van Breemen,R.B.; Schmitz,H.H.; Schwartz,S.J. Fast Atom Bombardment Tandem Mass Spectrometry of Carotenoids. Journal of Agricultural and Food Chemistry 1995, 43, 384-389.
  203. Spanos, G. A.; Schwartz, S. J.; van Breemen, R. B.; Huang, C.-H. High-performance liquid chromatography with light-scattering detection and desorption chemical-ionization tandem mass spectrometry of milk fat triacylglycerols. Lipids, 1995 30, 85-90.
  204. van Breemen, R. B.; Tsou, Y.; Connolly, G. Oxidation of dicyclopentadiene in surface water. Biol. Mass Spectrom. 1993 22, 579-584.
  205. Blackburn, R. K.; van Breemen, R. B. Degradation of the cyclic peptide antibiotic lysobactin by immobilized digestive proteases. Drug Metab. Dispos. 1993 21, 573-579.
  206. Oommen, T. V.; Petrie, E. M.; van Breemen, R. B.; Haney, C. A. Analysis of furanic compounds from cellulose aging by GC-MS, and attempts to correlate with degree of polymerization. CIGRE Paper 110-02, CIGRE Symposium on Diagnostic and Maintenance Techniques. Berlin, Germany, April 19-21. 1993.
  207. Saljoughian, M.; Williams, P. G.; Morimoto, H.; Goodlett, D. R.; van Breemen, R. B. Tritiated diimide: A regio- and stereo-selective tritium labeling reagent. J. Chem. Soc., Chem. Commun. 1993 414-416.
  208. van Breemen, R. B.; Schmitz, H. H.; Schwartz, S. J. Continuous-flow fast atom bombardment liquid chromatography/mass spectrometry of carotenoids. Anal. Chem. 1993 65, 965-969.
  209. van Breemen, R. B.; Davis, R. G. Rates of peptide proteolysis measured using liquid chromatography and continuous-flow fast atom bombardment mass spectrometry. Anal. Chem. 1992 64, 2233-2237.
  210. Schmitz, H. H.; van Breemen, R. B.; Schwartz, S. J. Applications of fast atom bombardment mass spectrometry (FAB-MS) and continuous-flow FAB-MS to carotenoid analysis. Methods Enzymol. 1992 213, 322-336.
  211. Bumgardner, C. L.; Huang, C.-H.; van Breemen, R. B. Characterization of oligomers of 3,3,3-trifluoro-1-phenylpropyne and 1-phenylpropyne by mass spectrometry. J. Fluor. Chem. 1992 56, 175-187.
  212. van Breemen, R. B.; Huang, C.-H.; Bumgardner, C. L. Continuous-flow fast atom bombardment and field desorption mass spectrometry of oligomers of 3,3,3-trifluorophenylpropyne. Anal. Chem. 1991 63, 2577-2580.
  213. Freeman, H. S.; Hao, Z.; Sokolowska-Gajda, J.; van Breemen, R. B. Matrix selection in the FAB mass spectrometric analysis of synthetic dyes. Dyes and Pigments, 1991 16, 317-327.
  214. van Breemen, R. B.; Canjura, F. L.; Schwartz, S. J. Identification of chlorophyll derivatives by mass spectrometry. J. Agric. Food Chem. 1991 39, 1452-1456.
  215. van Breemen, R. B.; Bartlett, M. G.; Tsou, Y.; Culver, C.; Swaisgood, H.; Unger, S. E. Degradation of peptide drugs by immobilized digestive proteases. Drug Metab. Dispos. 1991 19, 683-690.
  216. van Breemen, R. B.; Canjura, F. L.; Schwartz, S. J. High-performance liquid chromatography-continuous-flow mass spectrometry of chlorophyll derivatives. J. Chromatogr. 1991 542, 373-383.
  217. van Breemen, R. B.; Martin, L. B.; Le, J. C. "Continuous-flow fast atom bombardment mass spectrometry of oligonucleotides." J. Am. Soc. Mass Spectrom. 1991 2, 157-163.
  218. Martin, L. B.; Schreiner, A. F.; van Breemen, R. B. Characterization of cisplatin adducts of oligonucleotides by fast atom bombardment mass spectrometry. Anal. Biochem. 1991 193, 6-15.
  219. Freeman, H. S.; van Breemen, R. B.; Esancy, J. F.; Hao, Z.; Ukponmwan, D. O.; Hsu, W.-N. Fast atom bombardment and desorption chemical ionization mass spectrometry in the analysis of involatile textile dyes. Textile Chemist and Colorist, 1990 22, 23-28.
  220. van Breemen, R. B.; Wheeler, J. J.; Boss, W. F. Identification of carrot inositol phospholipids by fast atom bombardment mass spectrometry. Lipids, 1990 25, 328-334.
  221. Goodlett DR, Armstrong FB, Creech RJ, van Breemen RB. Formylated peptides from cyanogen bromide digests identified by fast atom bombardment mass spectrometry. Anal. Biochem. 1990 186, 116-20.
  222. van Breemen RB, Martin LB, Schreiner AF. Formation of Negative ions of monosubstituted Group VIB pentacarbonyls during fast atom bombardment mass spectrometry. Org. Mass Spectrom. 1990 25, 3-8.
  223. van Breemen RB, Le JC. Enhanced sensitivity of peptide analysis by fast atom bombardment mass spectrometry using nitrocellulose as a substrate. Rapid Commun. Mass Spectrom. 1989 3, 20-4.
  224. van Breemen RB. Fast atom bombardment mass spectrometry with B/E linked scanning of ether- and thiophenol-linked glucuronides. In Cellular and Molecular Aspects of Glucuronidation, ed. by G. Siest, J. Magdalou, B. Burchell, vol. 173, pp. 211-9, Colloque INSERM/John Libbey Eurotext Ltd., 1988.
  225. van Breemen RB, Stogniew M, Fenselau C. Characterization of acyl-linked glucuronides by electron impact and fast atom bombardment mass spectrometry. Biomed. Environ. Mass Spectrom. 1988 17, 97-103 .
  226. van Breemen RB, Martin LB, Schreiner AF. Comparison of electron impact, desorption chemical ionization, field desorption, and fast atom bombardment mass spectra of nine monosubstituted Group VI metal carbonyls. Anal. Chem. 1988 60, 1314-8.
  227. Fenselau C, van Breemen R, Bradow G, Stogniew M. Acyl-linked glucuronides as reactive metabolites. Fed. Proc. 1987 46, 2436-9.
  228. van Breemen RB, Fenselau C, Cotter RJ, Curtis A.J., Connolly G. Derivatives of dicyclopentadiene in ground water. Biomed. Environ. Mass Spectrom. 1987 14, 97-102.
  229. van Breemen RB, Fenselau C, Mogilevsky W, Odell GB. Reaction of bilirubin glucuronides with serum albumin. J. Chromatogr. 1986 383, 387-92.
  230. van Breemen RB, Fenselau C. Reaction of 1-O-acyl glucuronides with 4-p-(nitrobenzyl)pyridine. Drug Metab. Dispos. 1986 14, 197-201.
  231. van Breemen RB, Fenselau CC, Dulik DM. Activated Phase II metabolites: Comparison of alkylation by 1-O-acyl glucuronides and acyl sulfates. in Biological Reactive Intermediates III, ed. by J.J. Kocsis, D.J. Jollow, C.M. Whitmer, J.O Nelson, and R. Snyder. pp. 423-9, Plenum Publishing Corp., New York, 1986.
  232. van Breemen RB, Fenselau C. Acylation of albumin by 1-O-acyl glucuronides. Drug Metab. Dispos. 1985 13, 318-20.
  233. van Breemen RB, Tabet J-C, Cotter RJ. Characterization of oxygen-linked glucuronides by laser desorption mass spectrometry. Biomed. Mass Spectrom. 1984 11, 278-83.
  234. Gibson W, van Breemen R, Fields A, LaFemina R, Irmiere A. D,L-α-Difluoromethylorinithine inhibits human cytomegalovirus replication. J. Virology. 1984 50, 145-54.
  235. van Breemen RB, Snow M, Cotter RJ. Time resolved laser desorption mass spectrometry, I. Desorption of preformed ions. Int. J. Mass Spectrom. Ion Phys. 1983 49, 35-50.
  236. Cotter RJ, van Breemen R, Yergey J, Heller D. Thermal, laser, and fast atom desorption. Int. J. Mass Spectrom. Ion Proc. 1983 46, 395-8.

Chapters in Books

  1. van Breemen RB. Chapter 5: Pharmaceutical Applications: On-line ultrafiltration mass spectrometry, principles and applications. In Encyclopedia of Mass Spectrometry Volume 8: Hyphenated Methods. Ed. by Niessen WM. Elsevier Science, Oxford, UK, pp 515-522, 2006
  2. Fong HHS, Pauli GF, Bolton JL, van Breemen RB, Banuvar S, Shulman L, Geller SE and Farnsworth NR. Chapter 2: Evidence-based herbal medicine: Challenges in efficacy and safety assessments. In Annals of Traditional Chinese Medicine – Vol. 2. Current Review of Chinese Medicine: Quality Control of Herbs and Herbal Medicine. Ed. by Leung PC, Fong H, Xue CC. World Scientific, New Jersey, pp 11-26, 2006
  3. van Breemen RB. Chapter 4: Natural products from plants. In The Encyclopedia of Mass Spectrometry, Volume 3: Biological Applications, Part B: Carbohydrates, Nucleic Acids and other Biological Compounds. Ed. by Caprioli RM. Elsevier, Oxford, UK, pp 317-322, 2006
  4. Pajkovic N and van Breemen RB. Chapter 8: Analysis of carotenoids using atmospheric pressure chemical ionization mass spectrometry. In Modern Methods of Lipid Analysis. Ed. by Byrdwell WC. AOCS Press, Champaign, IL, pp 413-430, 2005
  5. Constantinou AI and van Breemen RB. Lycopene, a dietary cancer chemopreventive agent. In Cancer Chemoprevention, Volume 1: Promising Cancer Chemoprevention Agents. Ed. by Kelloff GJ, Hawk ET, and Sigman CC. Humana Press, Totowa, NJ, pp 525-535, 2004
  6. van Breemen RB. Mass spectrometry and drug discovery. In Burger’s Medicinal Chemistry and Drug Discovery. 6th Edition, Volume 1: Drug Discovery. Ed. By Abraham DJ. John Wiley & Sons, New York, 2003
  7. van Breemen RB. Introduction to mass spectrometry for food chemistry. In Current Protocols in Food Analytical Chemistry. Ed. by Wrolstad RE. John Wiley & Sons, New York, Appendix 3A.1-3A.7, 2001
  8. van Breemen RB. Mass spectrometry of chlorophylls. In Current Protocols in Food Analytical Chemistry. Ed. by Wrolstad RE. John Wiley & Sons, New York, pp F4.5.1-F4.5.9, 2001
  9. van Breemen RB. Mass Spectrometry of carotenoids. In Current Protocols in Food Analytical Chemistry. Ed. by Wrolstad RE. John Wiley & Sons, New York, pp F2.4.1-F2.4.13, 2001.
  10. Barua AB, Olson JA, Furr HC, and van Breemen RB. Vitamin A and carotenoids. In Modern Chromatographic Analysis of the Vitamins, 3rd ed. Ed. by De Leenheer A, Lambert WE, and Van Bocxlaer JF. Marcel Dekker, Inc., New York, pp 1-74, 2000
  11. Fitzloff JF, Yat P, Lu LL, Awang, DVC, Arnason JT, van Breemen RB, Hall T, Blumenthal M, Fong HHS. Perspectives on the quality assurance of ginseng products in North America. In Advances in Ginseng Research – Proceedings of the 7th International Symposium on Ginseng. Ed. By Huh H, Choi KJ and Kim YC. The Korean Society of Ginseng, Seoul, Korea, September 22-25, 1998
  12. van Breemen RB, Woodbury CP, Venton DL. Screening molecular diversity using mass spectrometry. In Mass Spectrometry of Biological Molecules, 2nd ed. Ed. by Larsen BS, and McEwen CN. Marcel Dekker, New York, pp 99-113, 1998
  13. van Breemen RB. Mass spectrometry of textile dyes. In Advances in Colour Chemistry Series, pp. 96-116, Ed. by Peters AT, and Freeman HS. Blackie Academic & Professional, Chapman and Hall, Glasgow, 1995. Invited contribution.
  14. van Breemen RB. Structural analysis of phosphatidylinositol from carrot cell membranes by fast atom bombardment and tandem mass spectrometry. In Mass Spectrometry in the Molecular Sciences: A Tutorial, pp. 443-451, ed. by Gross ML. Kluwer Academic Publishers, Dordrecht, 1992. Invited contribution.

Patents

  1. UNITED STATES PATENT NO. 6,995,022 Screening of xenobiotics and endogenous compounds for metabolic transformation, formation of toxic metabolites, and bioavailability. 2006 February 7, Full Text
  2. UNITED STATES PATENT NO. 5,872,015 Molecular diversity screening method. 1999 February 16. Full Text