Evgeny Berdyshev, PhD

Principal Investigator, Institute for Personalized Respiratory Medicine
Assistant Professor of Pulmonary Medicine


Dr. Berdyshev's scientific interests are focused on biologically active lipids. His early work was dedicated to marine organisms as a source of biologically active ether lipids and to the synthesis of platelet activating factor (PAF). Significant efforts were made to create cryopreservation media particularly for genetic materials of marine organisms. Following this, his research concentrated on endocannabinoids as immunomodulatory and signaling molecules. This research led to a demonstration of signaling potency of endocannabinoid congeners that cannot bind to and activate cannabinoid receptors. A direct link between PAF stimulation and immediate synthesis and release of endocannabinoid 2-arachidonoylglycerol was also discovered. Dr. Berdyshev's recent work on sphingolipids and lysophosphatidic acid as mediators of pulmonary inflammation further extends his interest in lipids as active players of inflammatory processes. The development of new mass spectrometric methods for lipid identification and quantitation is one of his main priorities. The role for lysophospholipids and sphingolipids in lung cancer development is the most interesting direction for the expansion of Dr. Berdyshev's research interests. 



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