Welcome to The Machado Lab
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Roberto F. Machado, MD Principal Investigator, Institute for Personalized Respiratory Medicine Associate Professor of Pulmonary Medicine |
Dr. Machado's research focuses on hemolysis associated pulmonary hypertension, vascular endothelial function in pulmonary arterial hypertension and carbon monoxide biology and therapeutics in advanced lung diseases such as pulmonary hypertension. His research has contributed to the discovery of pulmonary hypertension as a major risk factor for death in adult patients with sickle cell disease. Using human oligonucleotide microarray platforms and bioinformatics tools, Dr. Machado's laboratory currently seeks to develop novel diagnostic, prognostic and therapeutic biomarkers for patients with complex disorders such as sickle cell disease-related lung diseases and pulmonary hypertension. He is also interested in identifying genetic modifiers in sickle cell disease and pulmonary hypertension. Dr. Machado's laboratory also utilizes animal models of sickle cell disease and pulmonary hypertension to investigate the role of the pulmonary vascular endothelium in regulating vasomotor tone, permeability, vascular proliferation and apoptosis. By combining these approaches, Dr. Machado seeks to gain novel insights into the pathogenesis and treatment of these complex lung disorders, which would hopefully lead to an improvement in the morbidity and mortality associated with sickle cell disease and pulmonary hypertension.