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Viswanathan Natarajan, PhD
Co-Director, Institute for Personalized Respiratory Medicine
Professor, Departments of Pharmacology & Medicine
University of Illinois, Chicago, IL
(312)355-5896
Research Interests:
* Oxidants endothelial cell signaling and lung injury
* Expression, regulation and role of NOX proteins in lung injury
* Cytoskeletal regulation of NADPH oxidase in endothelium
* Sphingolipids in the pathobiology of lung injury
* Sphingosine Kinase1 as a novel target in mesothelioma
* LPA and LPA receptors in asthma
Background Information:
| 1981 - 1985 | Research Assistant Professor, Hormel Institute, University of Minnesota, Austin, MN 55912 |
| 1985 - 1986 | Assistant Professor, Department of Biochemistry/Molecular Cellular Biochemistry and Associate Consultant, Department of Neurology, Mayo Clinic, Rochester, MN 55906 |
| 1986 - 1988 | Manager/Section Leader, Lever Brothers India Ltd., Bombay, India |
| 1988 - 1989 | Visiting Associate Professor, The Hormel Institute, University of Minnesota, Austin, MN 55912 |
| 1989 - 1993 | Assistant Professor, Department of Medicine/Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 |
| 1993 - 1996 | Associate Professor, Department of Medicine/Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 |
| 1996 - 1998 | Professor Department of Medicine/Biochemistry and Molecular Biology/Biophysics and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202 |
| 1998 - 2005 | Professor, Department of Medicine, Johns Hopkins School of Medicine, Baltimore and Department of Environmental Sciences, School of Public Health, Johns Hopkins University, Baltimore, MD 21224 |
| 2005 - 2010 | Professor of Medicine, Department of Medicine, Section of Pulmonary & Critical Care Medicine/Division of Biological Sciences, University of Chicago, Chicago, IL 60637 |
| 2010 - Present | Professor, Departments of Pharmacology & Medicine Co-Director, Institute for Personalized Respiratory Medicine, University of Illinois, Chicago, IL60612 |
Editorial Activities:
Member of Editorial Board - Chemistry and Physics of Lipids (1996-2005)
Member of Editorial Board - Biochemical Journal (2001- Present)
Member of Editorial Board - American Journal Physiology-Lung, Molecular & Cellular Physiology (2004 - Present)
Member of Editorial Board - Antioxidants and Redox Signaling (2007 - Present)
Member of Editorial Board - Pulmonary Circulation (2010 - Present)
Editorial Consultant/Manuscript Reviewer:
American Journal Physiology: Lung, Cellular and Molecular Physiology
Biochimica ET Biophysica Acta
Journal of Neurochemistry
Lipids
Chemistry & Physics of Lipids
Journal of Lipid Research
American Journal of Respiratory Cell and Molecular Biology
Biochemical Journal
Circulation Research
Biochemical Journal
Antioxidants and redox Signaling
Journal of Immunology
Grant-Review Committee:
NIH - Lung Injury, Repair, & Remodeling Study Section (permanent member since 2008)
NIH - Cardiovascular Research Study Section (Ad hoc member)
Veterans Administration Merit Review
NIH/PPG (Ad hoc member)
NCI (Ad hoc member)
Select Publications for 2010-2011 (Total 180 publications in peer reviewed journals):
Pendyala, S., Moitra, J., Kalari, S., Reddy, S.P., Kleeberger, S.R., Zhao, Y., Garcia, J.G.N., and Natarajan, V. Nrf2 regulates hyperoxia-induced Nox4 gene expression in human lung endothelium via the antioxidant response element. Identification of cis-acting ARE on Nox4. Free Radical Biology & Medicine, In Press, January, 2011.
Zhao, Y., Gorshkova, I.A., Berdyshev, E., Ma, W., He, D., Su, Y., Usatyuk, P.V., Pendyala, S., Fu, P., Oskouian, B., Saba, J.D., Garcia, J.G.N., and Natarajan, V. Protection of LPS-induced murine acute lung injury and inflammation by sphingosine-1-phosphate lyase suppression. American J Respiratory Cell Molecular Biology, 45: 426-435, 2011.
Berdyshev, E., Gorshkova, I., Usatyuk, P.V., Kalari, S., Zhao, Y., Pyne, N.J., Pyne, S., Garcia, J.G.N., and Natarajan, V. Intracellular Sphhingosine-1-Phosphate is essential for Exogenous Sphingosine-1-Phosphate-induced Endothelial Cell Motility. Role of Sphingosine Kinase 1 and Sphingosine-1-Phospate Lyase. PLoS ONE, 6(1): e16571, 2011.
Usatyuk, P.V., He, D., Bindokas, V., Berdyshev, E.V., Garcia, J.G.N, Natarajan, V. Photolysis of Intracellular Caged Sphingosine-1-phosphate Causes G-protein Dependent and Independent Activation of Cell Signaling Pathways in Endothelial Cells. American Journal Physiology, Lung Cell Mol Physiol., 300: L840-850, 2011.
Pendyala, S., Moitra, J., Kalari, S., Reddy, S.P., Kleeberger, S.R., Zhao, Y., Garcia, J.G.N., and Natarajan, V. Nrf2 regulates hyperoxia-induced Nox4 gene expression in human lung endothelium via the antioxidant response element. Identification of cis-acting ARE on Nox4. Free Radical Biology & Medicine, In Press, January, 2011.
Loganathan, S., Kanteti, R., Siddiqui, S.S., El-Hashani, E., Tretiakova, M., Vigneswaran, H., Cervantes, G., Natarajan, V., Husain, A.N., Vokes, E.E., Kindler, H.L., and Salgia, R. Role of Protein kinase C beta and VEGF receptor in malignant pleural mesothelioma: Therapeutic Implications and the usefulness of C. elegans model organism. J. Carcinogenesis, 10: 4-12, 2011.
Berdyshev, E.V., Goya, J., Gorshkova, I., Prestwich, G.D., Byun, H-S., Bittman, R., and Natarajan, V. Characterization of sphingosine-1-phosphate lyase activity by ESI-LC/MS/MS quantitation of (2E)-hexadecenal. Analytical Biochemistry, 408: 12-18, 2011.
Pendyala, S., and Natarajan, V. Redox regulation of Nox proteins. Respiratory Physiology and Neurobiology, 174: 265-271, 2010.
Zhao, J., He, D., Su, Y., Berdyshev. E.V., Chun,J ., Natarajan,V., and Zhao, Y. Lysophosphatidic acid (LPA) receptors modulate lipopolysaccharide-induced inflammation. American Journal Physiology, Lung Cell Mol Physiol., In Press, July 2011.
Zhao, J., He, D., Berdyshev, E.V., Zhong, M., Salgia, R., Morris, A.J., Smyth, S.S., Natarajan, V., and Zhao, Y. Autotaxin induces lung epithelial cell migration through lysoPLD activity dependent and independent pathways. Biochemical Journal, In Press, May 2011.
Zhao, J., Chen, Q., Li, H., Spannhake E. Wm., Natarajan, V., Zhao, Y. Lysophosphatidic acid increases soluble ST2 expression in mouse lung and human bronchial epithelial cells. Cell Signalling, In Press, August, 2011.
Research Funding:
National Institutes of Health RO1s and PPGs