Publications
2013
| Citation | Associated Structures |
|---|---|
| Light SH, Krishna SN, Bergan RC, Lavie A, Anderson WF (2013) "Crystal structure of a type II dehydroquinate dehydratase-like protein from Bifidobacterium longum" Journal of Structural Functional Genomics, 14, 25-30 | |
| Su Y, Karamitros CS, Nomme J, McSorley T, Konrad M, Lavie A (2013) "Free glycine accelerates the autoproteolytic activation of human asparaginase" Chemistry & Biology, 20 , 533-40 | |
| Samuel H Light, Wayne F Anderson, and Arnon Lavie (2013) “Reassessing the type I dehydroquinate dehydratase catalytic triad: Kinetic and structural studies of Glu86 mutants” Protein Science, 22, 418-24 |
2012
| Citation | Associated Structures |
|---|---|
| Katy A. Wong, Angela Russo, Xuerong Wang, Yun-Ju Chen, Arnon Lavie, and John P. O'Bryan (2012) “A New Dimension to Ras Function: A Novel Role for Nucleotide-Free Ras in Class II Phosphatidylinositol 3-Kinase Beta (PI3KC2β) Regulation” PLOS ONE 7, e45360. |
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| Julian Nomme, Ying Su, Manfred Konrad, and Arnon Lavie (2012) “Structures of Apo and Product-Bound Human l-Asparaginase: Insights into the Mechanism of Autoproteolysis and Substrate Hydrolysis” Biochemistry 51, 6816-26. | |
| Jens Gruber, Wei Cun See Too, Mun T Wong, Arnon Lavie, Theresa McSorley and Manfred Konrad (2012) “Balance of human choline kinase isoforms is critical for cell cycle regulation: implications for the development of choline kinase-targeted cancer therapy” FEBS Journal 279, 1915-28. | |
| Anton Neschadim, James CM Wang, Arnon Lavie and Jeffrey A Medin (2012) “Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer” Cancer Gene Therapy 19, 320-327. | |
| Anton Neschadim, James CM Wang, Takeya Sato, Daniel H Fowler, Arnon Lavie and Jeffrey A Medin (2012) “Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase” Molecular Therapy 20, 1002-13. | |
| Dean O Campbell, Shahriar S Yaghoubi, Ying Su, Jason T. Lee, Martin S Auerbach, Harvey Herschman, Nagichettiar Satyamurthy, Johannes Czernin, Arnon Lavie, and Caius Radu (2012) “Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe” Journal of Biological Chemistry 287, 446-54. |
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2011
| Citation | Associated Structures |
|---|---|
| Saugata Hazra, A Szewczak, Stephan Ort, Manfred Konrad, and Arnon Lavie (2011) “Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release” Biochemistry 50, 2870-2880. | |
| Samuel H Light, George Minasov, Ludmilla Shuvalova, SN Peterson, Michael Caffrey, Wayne F Anderson, and Arnon Lavie (2011) “A conserved surface loop in type I dehydroquinate dehydratases positions an active site arginine and functions in substrate binding” Biochemistry 50, 2357-2363. | |
| Samuel H Light, George Minasov, Ludmilla Shuvalova, Michael Caffrey, Wayne F Anderson, and Arnon Lavie (2011) “Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates” Journal of Biological Chemistry 286, 3531-3539. | |
| Julian Nomme, Alan S Fanning, Michael M Caffrey, Ming F. Lye, James M Anderson, and Arnon Lavie (2011) “The Src homology 3 domain is required for junctional adhesion molecule binding to the third PDZ domain of the scaffolding protein ZO-1” ” Journal of Biological Chemistry 286, 43352-60. | |
2010
| Citation | Associated Structures |
|---|---|
| Saugata Hazra, Manfred Konrad, and Arnon Lavie (2010) “The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues” Journal of Medicinal Chemistry 53, 5792-5800. | |
| Saugata Hazra, Stephan Ort, Manfred Konrad, and Arnon Lavie (2010) “Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues” Biochemistry 49, 6784-6790. | |
| Deirdre A Foley, Kristin G Swartzentruber, Arnon Lavie, and Karen J Colley (2010) “Structure and mutagenesis of neural cell adhesion molecule domains: evidence for flexibility in the placement of polysialic acid attachment sites” Journal of Biological Chemistry 285, 27360-27371. | |
| Ming Fong Lye, Alan S. Fanning, Ying Su, James M. Anderson, and Arnon Lavie (2010) “Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3 – guanylate kinase module” Journal of Biological Chemistry 285, 13907-13917. | |
| James J Kohler, Seyed H Hosseini, Ioan Cucoranu, Olga Zhelyabovska, Elgin Green, Kristopher Ivey, Allison Abuin, Earl Fields, Amy Hoying, Rodney Russ, Robert Santoianni, C Michael Raper, Qinglin Yang, Arnon Lavie and William Lewis (2010) “Transgenic cardiac-targeted overexpression of human thymidylate kinase” Laboratory Investigation 90, 383-90. |
2009
| Citation | Associated Structures |
|---|---|
| Saugata Hazra, Elisabetta Sabini, Stephan Ort, Manfred Konrad, and Arnon Lavie (2009) “Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase” Biochemistry 48, 1256–1263. |
2008
| Citation | Associated Structures |
|---|---|
| Elisabetta Sabini, Saugata Hazra, Stephan Ort, Manfred Konrad, and Arnon Lavie (2008) "Structural basis for substrate promiscuity of dCK" Journal of Molecular Biology 378(3):607-621. | |
| Theresa McSorley, Stephan Ort, Saugata Hazra, Arnon Lavie, and Manfred Konrad (2008) "Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues" FEBS Letters 582, 720-724. | |
| Cristina Gabellieri, Steven Reynolds, Arnon Lavie, Geoffrey S. Payne, Martin O. Leach and Thomas R.Eykyn (2008) “Therapeutic target metabolism observed using hyperpolarized 15N choline” Journal of the American Chemical Society 130, 4598-4599. | |
| Arnon Lavie, Ying Su, Mahmood Ghassemi, Richard M. Novak, Michael Caffrey, Nikolina Sekulic, Christian Monnerjahn, Manfred Konrad and James L. Cook (2008) “Restoration of the antiviral activity of 3'-azido-3'- deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cells” Journal of General Virology 89, 1672-9. | |
| Elisabetta Sabini, Saugata Hazra, Manfred Konrad, and Arnon Lavie (2008) “Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase” Journal of Medicinal Chemistry 51, 4219-4225. | |
| Michael Sacher, Yeon-Gil Kim, Arnon Lavie, Byung-Ha Oh, and Nava Segev (2008) “The TRAPP complex: insights into its architecture and function” Traffic 9, 2032-2042. | |
| Ingo Paarmann, Ming F. Lye, Arnon Lavie and Manfred Konrad (2008) “Structural requirements for calmodulin binding to membrane-associated guanylate kinase homologs” Protein Science 17, 1946-54. |
2007
| Citation | Associated Structures |
|---|---|
| Dario Segura-Pena, Joseph Lichter, Manuela Trani, Manfred Konrad, Arnon Lavie, and Stefan Lutz (2007) "Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes" Structure 15, 1555-66. | |
| Alan S. Fanning, Ming F. Lye, James M. Anderson, and Arnon Lavie (2007) "Domain swapping within PDZ2 is responsible for dimerization of ZO proteins" Journal of Biological Chemistry 282, 37710-16 | |
| Nikolina Sekulic, Manfred Konrad, and Arnon Lavie (2007) "Structural mechanism for substrate inhibition of the adenosine 5'-phosphosulfate kinase domain of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 and its ramifications for enzyme regulation" Journal of Biological Chemistry 282, 22112-21. | |
| Elisabetta Sabini, Saugata Hazra, Manfred Konrad, and Arnon Lavie (2007) "Nonenantioselectivity Property of Human Deoxycytidine Kinase Explained by Structures of the Enzyme in Complex with l- and d-Nucleosides" Journal of Medicinal Chemistry 50, 3004-14. | |
| Dario Segura-Pena, Stefan Lutz, Christian Monnerjahn, Manfred Konrad, and Arnon Lavie (2007) "Binding of ATP to TK1-like Enzymes Is Associated with a Conformational Change in the Quaternary Structure" Journal of Molecular Biology 369, 129-141. | |
| Takeya Sato, Anton Neschadim, Manfred Konrad, Daniel H Fowler, Arnon Lavie and Jeffrey A Medin (2007) "Engineered Human tmpk/AZT As a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy" Molecular Therapy 15, 962-70. | |
| Nikolina Sekulic, Kristen Dietrich, Ingo Paarmann, Stephan Ort, Manfred Konrad and Arnon Lavie (2007) "Elucidation of the Active Conformation of the APS-Kinase Domain of Human PAPS Synthetase 1" Journal of Molecular Biology 367, 488-500. | |
| Elisabetta Sabini, Saugata Hazra, Manfred Konrad, Stephen K. Burley, and Arnon Lavie (2007) "Structural basis for activation of the therapeutic l-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase" Nucleic Acids Research 35, 186–192. |
2006
| Citation | Associated Structures |
|---|---|
| Enrico Malito, Nikolina Sekulic, Wei Cun See Too, Manfred Konrad and Arnon Lavie (2006) "Elucidation of Human Choline Kinase Crystal Structures in Complex with the Products ADP or Phosphocholine" Journal of Molecular Biology 364, 136-151. | |
Shalu Shiv Mendiratta, Nikolina Sekulic, Francisco G. Hernandez-Guzman, Brett E. Close, Arnon Lavie, and Karen J. Colley (2006) "A Novel  -Helix in the First Fibronectin Type III Repeat of the Neural Cell Adhesion Molecule Is Critical for N-Glycan Polysialylation" Journal of Biological Chemistry 281, 36052-36059.
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| Michael H. Godsey, Stephan Ort, Elisabetta Sabini, Manfred Konrad, and Arnon Lavie (2006) "Structural Basis for the Preference of UTP over ATP in Human Deoxycytidine Kinase: Illuminating the Role of Main-Chain Reorganization" Biochemistry 45, 452 - 461. |
2005
| Citation | Associated Structures |
|---|---|
| Yuanhe Li, Alan S. Fanning, James M. Anderson, and Arnon Lavie (2005) "Structure of the conserved cytoplasmic C-terminal domain of occludin: identification of the ZO-1 binding surface" Journal of Molecular Biology 352, 151-64. | |
| Shalu Shiv Mendiratta, Nikolina Sekulic, Arnon Lavie, and Karen J. Colley (2005) "Specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule play a role in its recognition and polysialylation by the polysialyltransferase ST8Sia IV/PST" Journal of Biological Chemistry 280, 32340-8. |
2004
| Citation | Associated Structures |
|---|---|
| Yuanhe Li, David Karnak, Borries Demeler, Ben Margolis, and Arnon Lavie (2004) "Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes" EMBO Journal 23, 2723-33. | |
| Dario Segura-Pena, Nikolina Sekulic, Stephan Ort, Manfred Konrad, and Arnon Lavie (2004) "Substrate-induced conformational changes in human UMP/CMP kinase" Journal of Biological Chemistry 279, 33882-9. | |
| Arnon Lavie and Manfred Konrad (2004) "Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase" Mini Reviews in Medicinal Chemistry 4, 351-9. |
2003
| Citation | Associated Structures |
|---|---|
| Anna Gardberg, Ludmilla Shuvalova, Christian Monnerjahn, Manfred Konrad, and Arnon Lavie (2003) "Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases" Structure 11, 1265-77. | |
| Elisabetta Sabini, Stephan Ort, Christian Monnerjahn, Manfred Konrad, and Arnon Lavie (2003) "Structure of human dCK suggests strategies to improve anticancer and antiviral therapy" Nature Structural Biology 10, 513-9. | |
| Nils Ostermann, Dario Segura-Pena, Chris Meier, Thomas Veit, Christian Monnerjahn, Manfred Konrad, and Arnon Lavie (2003) "Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds" Biochemistry 42, 2568-77. |
2002
| Citation | Associated Structures |
|---|---|
| Ingo Paarmann, Oliver Spangenberg, Arnon Lavie, and Manfred Konrad (2002) "Formation of complexes between Ca2+.calmodulin and the synapse-associated protein SAP97 requires the SH3 domain-guanylate kinase domain-connecting HOOK region" Journal of Biological Chemistry 277, 40832-8. | |
| Nikolina Sekulic, Ludmilla Shuvalova, Oliver Spangenberg, Manfred Konrad, and Arnon Lavie "Structural characterization of the closed conformation of mouse guanylate kinase" (2002) Journal of Biological Chemistry 277, 30236-43. | |
| Yunahe Li, Oliver Spangenberg, Ingo Paarmann, Manfred Konrad, and Arnon Lavie "Structural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domains" (2002) Journal of Biological Chemistry 277, 4159-65. |
2000
| Citation | Associated Structures |
|---|---|
| Nils Ostermann, Arnon Lavie, Sreekanta Padiyar, Ralf Brundiers, Thomas Veit, Jochen Reinstein, Roger S. Goody, Manfred Konrad, and Ilme Schlichting "Potentiating AZT activation: Structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP" (2000) Journal of Molecular Biology 304, 43-53. | |
| Nils Ostermann, Ilme Schlichting, Ralf Brundiers, Manfred Konrad, Jochen Reinstein, Thomas Veit, Roger S. Goody, and Arnon Lavie "Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate" (2000) Structure with Folding Design 8, 629-42. |
1999
| Citation | Associated Structures |
|---|---|
| Ralf Brundiers R, Arnon Lavie, Thomas Veit, Jochen Reinstein, Ilme Schlichting, Niles Ostermann, Roger S. Goody, and Manfred Konrad "Modifying human thymidylate kinase to potentiate azidothymidine activation" (1999) Journal of Biological Chemistry 274, 35289-92. | |
| Heino Prinz , Arnon Lavie , Axel J. Scheidig, Oliver Spangenberg, and Manfred Konrad"Binding of nucleotides to guanylate kinase, p21(ras), and nucleoside-diphosphate kinase studied by nano-electrospray mass spectrometry" (1999) Journal of Biological Chemistry 274, 35337-42. |
1998
| Citation | Associated Structures |
|---|---|
| Arnon Lavie, Nils Ostermann, Ralf Brundiers, Roger S. Goody, Jochen Reinstein, Manfred Konrad, and Ilme Schlichting"Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase" (1998) Proceedings of the National Academy of Sciences 95, 14045-14050. | |
| Arnon Lavie, Manfred Konrad, Ralf Brundiers, Roger S. Goody, Ilme Schlichting, and Jochen Reinstein "Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl)P5-thymidyl) pentaphosphate (TP5A) at 2.0 Å: Implications for catalysis and AZT activation" (1998) Biochemistry 37, 3677-3686. | |
| Arnon Lavie, Jochen Reinstein, Roger S. Goody, Ilme Schlichting, and Manfred Konrad "Improving AZT efficacy" (1998) Nature Medicine 4, 132. |
1997
| Citation | Associated Structures |
|---|---|
| Arnon Lavie, Ilme Schlichting, Ingrid R. Vetter, Manfred Konrad, Jochen Reinstein, and Roger S. Goody "The bottleneck in AZT activation" (1997) Nature Medicine 3, 922-924. | |
| Arnon Lavie, Ingrid R. Vetter, Manfred Konrad, Roger S. Goody, Jochen Reinstein, and Ilme Schlichting "Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation" (1997) Nature Structural Biology 4, 601-604. |
1995
| Citaiton | Associated Structures |
|---|---|
| Karen N. Allen, Arnon Lavie, Gregory A. Petsko, and Dagmar Ringe "Design, synthesis, and characterization of a potent xylose isomerase inhibitor, d-threonohydroxamic acid, and high resolution X-ray crystallographic structure of the enzyme-inhibitor complex" (1995) Biochemistry 34, 3742-3749. |
1994
| Citation | Associated Structures |
|---|---|
| Arnon Lavie, Karen N. Allen, Gregory A. Petsko, and Dagmar Ringe "X-ray crystallographic structures of d-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis" (1994) Biochemistry 33, 5469-5480. | |
| Karen N. Allen, Arnon Lavie, Arthur Glasfeld, Timothy N. Tanada, Daniel P. Gerrity, Steven C. Carlson, Gregory K. Farber, Gregory A. Petsko, and Dagmar Ringe "Role of the divalent metal ion in sugar binding, ring opening, and isomerization by d-xylose isomerase: Replacement of a catalytic metal by an amino-acid" (1994) Biochemistry 33, 1488-1494. | |
| Karen N. Allen, Arnon Lavie, Gregory K. Farber, Arthur Glasfeld, Gregory A. Petsko, and Dagmar Ringe "Isotopic exchange plus substrate and inhibition kinetics of d-xylose isomerase do not support a proton-transfer mechanism" (1994) Biochemistry 33, 1481-1487. |
