CURRICULUM VITAE

 

BERNARD D. SANTARSIERO

 

Research Professor

The Center for Pharmaceutical Biotechnology

University of Illinois at Chicago

1052B-MBRB  MC870

900 South Ashland Avenue

Chicago, IL 60607

Office Phone: (312) 413-0339

FAX: (312) 413-4304 or 413-9303

Email: bds@uic.edu

 

HOMETOWN           Pomona, California

 

EDUCATION           B.Sc. (Chemistry), Harvey Mudd College, Claremont, CA, 1975

                              M.Sc. (Chemistry), University of Washington, Seattle, WA, 1977

                              Ph.D. (Physical Chemistry), University of Washington, Seattle, WA, 1980

                                                                             

PROFESSIONAL EXPERIENCE

 

Sep 1975-Jun 1979 Standard Oil Company of California Research Fellow, UWashington

Sep 1977-Sep 1979 Pre-doctoral Instructor, Chemistry, UWashington

1981-1984              Myron A. Bantrell Research Fellow in Chemical Catalysis, Caltech

1984-1987              Director, X-Ray Diffraction Facility, Caltech

1984-1987              Coordinator and Instructor, Chem 1, Caltech

1985-1987              Deputy Master of Student Houses, Caltech

Jan 1987-Aug 1987 Visiting Scientist, Department of Chemistry and Department of Biological Structure, UWashington

Sep 1987-Jun 1989 Research Associate, Department of Biochemistry, UAlberta

Jun 1988-Sep 1991 Director, Structure Determination Laboratory, UAlberta

Sep 1991-Nov 1995 Manager, Macromolecular Crystallography, Molecular Structure Corp

Nov 1995-Nov 1997 Visiting Scholar, Department of Chemistry, UCBerkeley

Nov 1996-Dec 2000 Project Manager, High-throughput Robotics for Synchrotron Data Collection, Advanced Light Source, Beamline 5.0.3, Berkeley National Laboratory (LNBL)

Jan 1997-Dec 2000  Project Manager, High-throughput Robotics for Protein Microcrystallization, Division of Physical BioSciences, LNBL

Nov1997-Feb 1999  Staff Scientist, Physical BioSciences Division, LBNL

Feb 1999-Jul 2000   Staff Scientist and Group Leader, Proteomics, Genomics Institute of the Novartis Research Foundation (GNF, formally NIFG)

Feb 1999-Sep 2000 Guest Scientist, Physical BioSciences Division, LBNL

Oct 1999-Sep 2000  Visiting Investigator, Molecular Biology, The Scripps Research Institute

Dec 2000-Dec 2001 Visiting X-Ray Research Specialist, The Center for Pharmaceutical Biotechnology, UIC

Dec 2001-April 2003                                               Visiting Research Assistant Professor, The Center for Pharmaceutical Biotechnology, UIC

April 2003-              Research Professor, The Center for Pharmaceutical Biotechnology, UIC

 

COMMITTEES

 

Mar 1976-Jun 1980  Curriculum, College of Arts and Science, UWashington

Jun 1978-Jun 1979  Chairman, Facilities, Budget and Planning, GPSS, UWashington

Jun 1978-Jun 1979  Faculty Council on Planning and Priorities, UWashington          

Jun 1978-Mar 1980  Capitol and Space Planning Office , UWashington 

Sep 1979-Mar 1980 Provost ad hoc Planning, Physics, UWashington

Jan1993-Nov 1995   ASSET:  Alliance Serving Science Engineering and Technology, The Woodlands Corporation

Dec 1996-Aug 1997 Chair, MCB/Stanley Hall X-Ray Diffraction Facility, UCBerkeley

Sep 2002-               Member, SER-CAT Automation Committee

 

 

OTHER PROFESSIONAL ACTIVITIES

 

Dec 1986                 Visiting Committee, Student Affairs, Harvey Mudd College

Jun 1987-Jan 1989  Visiting Consultant, Wyeth Laboratories

1980-                     Journal Referee: Acta Crystallog., Can. J. of Chem., Inorg. Chem., J. Amer. Chem. Soc., Organometallics, J. Nat. Prod.

May 1993                Co-chair, Organic and Biochemical Compounds, ACA Ann. Mtg.

Jun 1994                 Co-chair, Protein Crystallization Session, ACA Ann. Mtg.

Jun 1995-Jan 1999  Consultant, Rigaku Corporation

Jan 1997-Dec 1999  Apparatus and Standards Standing Comm., ACA (Chair, 1999)

Aug 1997-Jan 1999  Customer Advisory Board, Molecular Structure Corporation

Jun 1998                 Co-organizer, CCD Detectors, ACA Ann. Mtg.

Jan 1998-Jan 1999   Consultant, Molecular Structure Corporation

Feb 1999-Dec 2002  Co-founder and Consultant, Syrrx (formally Agencor)

Nov 2000                Organizer, R-AXIS Users Meeting 2000, Houston, TX

1998-                      Structural Biology Review Board, NASA

Dec 2001-July 2005 Local co-chair, ACA Annual Meeting, Chicago, IL 2004

Sep 2002                 Awardee, R&D100 Awards for 2002 (Nanodrop crystallization)

Oct 2002-                Consultant, Lord Bissel & Brook

Dec 2002-               Instructor, ACA Crystallography Summer Course, Chicago, IL

Dec 2003-               Manager, Information Technology Services, Ctr for Pharm Biotechnology

Oct 2003-                Manager, CPB/RRC Small Molecule X-ray Diffraction Facility

Oct 2004-                Co-Manager, RRC Macromolecular X-ray Diffraction Facility

Dec 2003-               Science Advisory Board, Shamrock Structures

 

                             


PATENTS

 

1.    “Methods and Apparatus for Performing Array Microcrystallizations,” Patent No. 6,296,673, awarded  2 Oct 2001.

 

2.    “Method for Screening Microcrystallizations for Crystal Formation,” App. No. 20020110816, Filed 15 August 2002, Patent No. 6,630,006 awarded 7 October 2003.

 

3.    “Mother Liquor Fluid Delivery Apparatus, ” App. No. 20020143153, Filed 3 Oct 2002.

 

4.    “Method for Diffracting Crystals Formed by Submicroliter Crystallization Experiments," App. No. 20020155504, 24 Oct 2002.

 

5.    “Method for Performing Submicroliter Crystallization Experiments, ” App. No. 20020160426, Filed 31 Oct 2002.

 

6.    “Method for Performing Submicroliter Crystallization Experiments with High Experiment to Experiment Precision, ” App. No. 20020173052, Filed 21 Nov 2002.

 

7.    “Method for Screening Microcrystallizations for Crystal Formation, ” App. No. 20020182637, Filed 5 Dec 2002.

 

8.     “Automated Crystallization Experiment Setup Apparatus Comprising Crystallization Device Identification Code Reader,” App. No. 20030096293, Filed 22 May 2003.

 

9.    “Automated Method for Setting Up Crystallization Experiments Employing a Crystallization Device Idenfication Code Reader,” App. No. 20030096294, Filed 22 May 2003.

 

10.         “Multiwell Plate Adapted for Automated Crystallization,” App. No. 20030109046, Filed 12 June 2003.

 

11.         “Automated Crystallization Experiment Setup Apparatus Comprising Sensor,” App. No. 20030109063, Filed 12 June 2003.

 

12.         “Automated Crystallization Experiment Setup Apparatus,” App. No. 20030109064, Filed 12 June 2003.

 

13.         “High Density Crystallization Experiment Device,” App. No. 20030109065, Filed 12 June 2003.

 

14.         “Method for Performing High Density Submicroliter Crystallization Experiments,” App. No. 20030109066, Filed 12 June 2003.

 

15.         “Method Involving Submicroliter Crystallization and Subsequent Scale Up Experiment,” App. No. 20030113804, Filed 19 June 2003.

 

16.         “Dispenser Footprint Greater than Plate Footprint,” App. No. 20030119048, Filed 26 June 2003.

 

17.         “Integrated Crystal Mounting and Alignment System for High-throughput Biological Crystallography,” App. No. 20030152194, Filed 14 August 2003.

 

Recent Publication List (over 100 publications in print)

 

88. “Superstructure Control in the Crystal Growth and Ordering of Urea Inclusion Compounds,” with M. D. Hollingsworth, M. E. Brown, A. C. Hillier, and J. D. Chaney, Science, 273, 1355-1359 (1996).

 

89. “Structural Studies of Catalytic Antibodies,” with R. C. Stevens, L. C. Hsieh-Wilson, G. J. Wedemeyer, B. W. Spiller, L. H. Wang, D. Barnes, H. D. Ulrich, P. A. Patten, B. D. Santarsiero, F. E. Romesberg, and P. G. Schultz, Israel J. Chem., 36, 121-132 (1996).

 

90. “The Interplay Between the Binding and Catalysis in the Evolution of a Catalytic Antibody,” with H. Ulrich, E. Mundorff, B. D. Santarsiero, E. Driggers, R. C. Stevens, and P. G. Schultz,” Nature, 389. 271­-276 (1997).

 

91. “Structural Basis of Allosteric Autoregulation of Phenylalanine Hydroxylase,” with B. Kobe, I. G. Jennings, C. M. House, B. J. Michell, K. E. Goodwill, B. D. Santarsiero, R. C. Stevens, R. G. H. Cotton, and B. E. Kemp, Nature, Structural Biology, 6, 422-428 (1999).

 

92. “Structural and Kinetic Evidence for Strain in Biological Catalysis,” with F. E. Romesberg, B. D. Santarsiero, B. W. Spiller, J. Yin, D. Barnes, P. G. Schultz, and R. C. Stevens, Biochemistry, 37, 14404-9 (1998).

 

93. “Alternative Metal Binding Sites in Rubrerythrin: Which is the Functional Binuclear Center?” with L. C. Sieker, M. Holmes, I. Le Trong, S. Turley, B. D. Santarsiero, M. -Y. Liu, J. LeGall, and R. E. Stenkamp, Nature, Structural Biology, 6, 200 (1999).

 

94.“Synthesis and X-ray Crystal Structure of (-)-calicheamicinone,” with D. L. J. Clive, Y. Bo, N. Selvakumar, B. D. Santarsiero, and R. McDonald, Tetrahedron, 55, 3277-3290 (1999).

 

95. “Accelerated Protein Crystallization Using Nanodroplets,” with B. D. Santarsiero, D. T. Yegian, D. C. Uber, E. W. Cornell, C. C. Lee, G. Spraggon, J. Gu, D. Scheibe, R. A. Nordmeyer, W. F. Kolbe, J. Jin, A. L. Jones, J. M. Jaklevic, P. G. Schultz, and R. C. Stevens, J. Appl. Cryst., 35, 1-4 (2002).

 

96. “Isolation, Structure Elucidation, and Absolute Configuration of 26-deoxyactein From Cimicifuga racemosa and Clarification of Nomenclature Associated with 27-deoxyactein,” with S. H. Chen, W. Li, D. S. Fabricant, B. D. Santarsiero, A. D. Mesecar, J. F. Fitzloff, H. H. S. Fong, and N. R. Farnsworth, J. Nat. Prod., 65, 601-605 (2002).

 

97. “Bioactive Constituents of the Seeds of Brucea javanica,” with B. N. Su, L. C. Chang, E. J. Park, M. Cuendet, B. D. Santarsiero, A. D. Mesecar, R. G. Mehta, H. H. S. Fong, J. M. Pezzuto, and A. D. Kinghorn, Planta Medica, 68, 730-733  (2002).

 

98. “New Chemical Constituents of Euphorbia Quinquecostata and Absolute Configuration Assignment by a Convenient Mosher Ester Procedure Carried out in NMR Tubes,” with B. N. Su, E. J. Park, Z. H. Mbwambo, B. D. Santarsiero, A. D. Mesecar, , H. H. S. Fong, R. G. Mehta, J. M. Pezzuto, and A. D. Kinghorn, J. Nat. Prod., 65, 1278-1282 (2002).

 

99. “Isolation and Characterization of Bioactive Principles of the Leaves and Stems of Physalis philadelphica,” with B. N. Su, R. Misico, E. J. Park, B. D. Santarsiero, A. D. Mesecar, H. H. S. Fong, J. M. Pezzuto, and A. D. Kinghorn, Tetrahedron, 58, 3453-3466 (2002).

 

100. “Constituents of Musa sapeintum (Banana) with the Potential to Induce the Phase II Enzyme, Quinone Reductase,” with D. S. Jang, E. J. Park, M. E. Hawthorne, J. S. Vigo, J. G. Graham, F. Cabieses,, B. D. Santarsiero, A. D. Mesecar, H. H. S. Fong, R. G. Mehta, J. M. Pezzuto, and A. D. Kinghorn, J. Agric. Food. Chem., 50, 6330-6334  (2002)

 

101. “Vitexlactam A, A Novel Labdane Diterpene Lactam From the Fruits of Vitex agnus-castus,” with S.-H. Li, H.-J. Zhang, S.-X. Qiu, X.-M. Niu, B. D. Santarsiero, A. D. Mesecar, H. H. S. Fong, N. R. Farnsworth, and H.-D. Sun, Tet. Lett., 43, 5131-5134 (2002).

 

102. “Regioselective Covalent Modification of Hemoglobin in Search of Antisickling Agents,” with S. Park, B. L. Hayes, F. Marankan, D. Mulhearn, L. Wanna, B. D. Santarsiero, A. D. Mesecar, M. E. Johnson, and  D. L. Venton, J. Med. Chem., 46, 936-953 (2003).

 

103. “Activity-Guided Isolation of Novel Norwithanolides from Solanum altissimum with Potential Cancer Chemopreventive Activity,” with B.-N. Su, E. J. Park, B. D. Santarsiero, A. D. Mesecar, J. S. Vigo, J. G. Graham, F. Cabieses, H. H. S. Fong, N. R. Farnsworth, J. M. Pezzuto, and A. D. Kinghorn, J. Org. Chem., 68, 2350-2361 (2003).

 

104. “New Chemical Constituents of Euphorbia quinquescostata and Absolute Configuration Assignment by a Convenient Mosher Ester Procedure Carried Out in NMR Tubes,” with B.-N. Su, E. J. Park, Z. H. Mbwambo, B. D. Santarsiero, A. D. Mesecar, H. H. S. Fong, J. M. Pezzuto, and A. D. Kinghorn,     J. Nat. Prod., 65, 1278-1282  (2002).

 

105. “Potential Cancer Chemopreventive Constituents of the Seeds of Dipteryx odorata (Tonka Bean),” with D. S. Jang, E. J. Park, M. E. Hawthorne, J. S. Vigo, J. G. Graham, F. Cabieses,, B. D. Santarsiero, A. D. Mesecar, H. H. S. Fong, R. G. Mehta, J. M. Pezzuto, and A. D. Kinghorn, J. Nat. Prod., 66, 583-587 ( 2003).

 

106. “New Sesquiterpenes from Litsea verticillata,” with H.-J. Zhang, G. T. Tan, B. D. Santarsiero, A. D Mesecar, N. V. Hung, N. M. Cuong, D.D. Soejarto, J. M. Pezzuto, and H. H. S. Fong, “,” J. Nat. Prod., 66,  609-615 (2003).

 

107. “New Manzamine Alkaloids with Activity Against Infections and Tropical Parasitic Diseases from an Indonesian Sponge,” with K. V. Rao, B. D. Santarsiero, A. D. Mesecar, R. F. Schinazi, B. L. Tekwani, and M. T.  Hamann, J. Nat. Prod., 66, 823-828 (2003).

 

108. “Isolation and Absolute Stereochemistry of Coussaric Acid, A New Bioactive Triterpenoid from the Stems of Coussaria brevicaulis,” with B.-N. Su, Y.-H. Kang, R. E. Pinos, B. D. Santarsiero, A. D. Mesecar, D. D. Soejarto, H. H. S. Fong, J. M. Pezzuto, and A. D. Kinghorn, Phytochemistry, 64, 293-302 (2003).

 

109. “Antimycobaterial Naphthopyrones from Senna oblique,” with J. G. Graham, H. Zhang, S. L. Pedlund, B. D. Santarsiero, A. D. Mesecar, F. Cabieses, and N. R. Farnsworth, J. Nat. Prod., 67, 225-227 (2004).

 

110. “Silvestrol and Episilvestrol, Potential Anticancer Rocaglate Derivatives from Aglaia silvestris,” with B. Y. Hwang, B.-N. Su, H. Chai, Q, Mi, L. B. Kardino, J. J. Afriastini, S. Riswan, B. D. Santarsiero, A. D. Mesecar, R. Wild, C. R. Fairchild, G. D. Vite, W. C. Rose, N. R. Farnsworth, . A. Cordell, J. M. Pezzuto, S. M. Swanson, and A. D. Kinghorn, J. Org. Chem., 69, 3350-3358 (2004).

 

111. “New 3-O-acyl betulinic acids from Strychnos vanprukii Craib,” with Q. C. Nguyen, V. H. Nguyen, B. D. Santarsiero, A. D. Mesecar, M. C. Nguyen, D. D. Soejarto, J. M. Pezzuto, H. H. S. Fong, and G. T. Tan, J. Nat. Prod., 67, 994-998 (2004).

 

112. “The Structure of Hexamethylbenzene in Phase II at 298K and Phase III at 20K,” with E. J. Valente S. Samson, and B. D. Santarsiero, J. Am. Chem. Soc., in preparation (2004).