Lynn Birch, MS

 

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EDUCATION

Masters of Science, Biological Sciences, Northern Illinois University, May 1987, DeKalb, IL. Thesis: "Leucyl-tRNA Synthetases in Chinese Hamster Ovary Cells: Functional Studies on Wild Type Cells."

Bachelor of Science, Biological Sciences, Chemistry minor, Northern Illinois University, May 1982, DeKalb, IL.

AWARDS

1997  $500 Affinity BioReagents Travel Award for the 79th Annual Endocrine Society Meetings in Minneapolis, MN.

PUBLICATIONS

Prins GS, Birch L, Greene GL: Androgen receptor localization in different cell types of the adult rat prostate. Endocrinology 129,6:3187-3199, 1991.

Prins GS, Cooke PS, Birch L, Donjacour AA, Yalcindaya TM, Siiteri PK, Cunha GR: Androgen receptor expression and 5a-reductase activity along the proximal-distal axis of the rat prostatic duct. Endocrinology 130,5:3066-3073, 1992.

Prins GS, Cecim M, Birch L, Wagner TE, Bartke A: Growth response and androgen receptor expression in seminal vesicles from aging transgenic mice with human and bovine growth hormone. Endocrinology 131,4:2016-2023, 1992.

Prins GS, Birch L: Immunocytochemical analysis of androgen receptor along the ducts of the separate rat prostate lobes after androgen withdrawal and replacement. Endocrinology 132,1:169-178, 1993.

Prins GS, Woodham C, Lepinske M, Birch L: Effects of neonatal estrogen on prostatic secretory products and their correlation with androgen receptor expression in the adult rat prostate lobes. Endocrinology 132,6:2387-2398, 1993.

Rosenzweig BA, Bolina PS, Birch L, Moran C, Marcovici I, Prins GS: Location and concentration of estrogen, androgen and progesterone receptors in the bladder and urethra of the rabbit. Neurology & Urodynamics 14:87-96, 1995.

Prins GS, Birch L: The developmental pattern of androgen receptor regulation in the rat prostate lobes is altered following neonatal exposure to estrogen. Endocrinology 136,3:1303-1314, 1995.

Prins GS, Birch L: Neonatal estrogen exposure up-regulates estrogen receptor expression in the developing and adult rat prostate lobes. Endocrinology 138,5:1801-1809, 1997.

Prins GS, Marmer M, Woodham C, Chang W, Kuiper G, Gustafsson J-A, Birch L: Estrogen receptor beta mRNA ontogeny in the rat prostate and effects of neonatal estrogen exposure on the expression pattern. Endocrinology 139,3:874-883, 1998.

Chang WY, Wilson MJ, Birch L, Prins GS: Neonatal estrogen stimulates proliferation of periductal fibroblasts and alters the extracellular matrix composition in the rat prostate. Endocrinology 140,1:405-415, 1999.

Chang WY, Birch L, Woodham C, Gold LI, Prins GS: Neonatal estrogen exposure alters the transforming growth factor- signaling system in the developing rat prostate and blocks the transient p21cip1/waf1 expression associated with epithelial differentiation. Endocrinology 140,6:2801-2813, 1999.

Habermann H, Chang WY, Birch L, Mehta P, Prins GS: Developmental exposure to estrogens alters epithelial cell adhesion and gap junction proteins in the adult prostate. Endocrinology 142:359-369, 2001.

Prins GS, Birch L, Couse JF, Choi I, Katzenellenbogen B, Korach KS. Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor a: Studies with aERKO and ERKO mice. Cancer Research 61:6089-6097, 2001.

Prins GS, Birch L, Habermann H, Chang WC, Tebeau C, Putz O, Bieberich C: Influence of neonatal estrogens on mature prostate function. Reproductive Fertility & Development 13:241-252, 2001.

Gilleran JP, Putz O, DeJong M, DeJong S, Birch L, Pu Y, Huang L, Prins GS. The role of prolactin in the prostatic inflammatory response to neonatal estrogen. Endocrinology 144,5:2046-2054, 2003.

Woodham C, Birch L, Prins GS: Neonatal estrogens down regulate prostatic androgen receptor levels through a proteosome-mediated protein degradation pathway. Endocrinology 144(10):(in press), 2003.

Huang L, Pu Y, Alam S, Birch L, Prins GS. Review: Estrogenic Regulation of Signaling Pathways and Homeobox Genes during Prostate Development. J Andrology. (submitted), 2003.

ABSTRACTS

Prins GS, Birch L, Ghosh PK, Bartke A: Androgen receptor content in seminal vesicles from young and aged transgenic mice with human or bovine growth hormone. American Society of Andrology, Montreal, Canada, April 27-30, 1991.

Prins GS, Birch L, Cohen H: Effect of neonatal estrogen on androgen receptor concentration and distribution in the rat prostate lobes. Program of the 73rd Annual Endocrine Society Meetings, Washington DC, June 19-22, 1991, p. 161, #521.

Birch L , Prins GS: Immunocytochemical analysis of androgen receptor along the ducts of the separate rat prostate lobes following castration-induced androgen withdrawal. Program of the 74th Annual Endocrine Society Meetings, San Antonio, TX, June 24-27, 1992, p. 103, #207.

Prins GS, Woodham C, Birch L, Lepinske M: Effects of neonatal estrogen on prostatic secretory products and their correlation with androgen receptor expression in the adult rat prostate lobes. Program of the 74th Annual Endocrine Society Meetings, San Antonio, TX, June 24-27, 1992, p. 193, #568.

Rosenzweig BA, Prins GS, Bolina PS, Birch L, Moran C, Marcovici I: Steroid receptors of the lower urinary tract in the rabbit. The American College of Obstetrics and Gynecology, 1993.

Ngan JH, Prins G, Lee C, Sensibar J, Birch L, Wu A, Sharifi, R: Effect of long term steroid deprivation on response of androgen receptor protein to dihydrotestosterone (DHT) in LNCaP cells. Society for Basic Urological Research, Houston, TX, December 2-5, 1993.

Ngan JH, Lee C, Sensibar J, Prins G, Birch L, Sharifi, R: Androgen induced immediate androgen receptor (AR), prostatic specific antigen (PSA) and cellular protein changes in long term androgen deprived human prostate cancer. American Urologic Association Annual Meeting, San Francisco, CA, May 1994.

Prins GS, Birch L: Neonatal estrogen up-regulates estrogen receptor in prostatic smooth muscle cells and increases extracellular TGF1. Program of the 76th Annual Endocrine Society Meetings, Anaheim, CA, June 15-18, 1994, p. 496, #1183.

Prins GS, Birch L, Woodham C: Effect of neonatal estrogen on androgen receptor protein and mRNA levels in developing rat ventral prostate. Program of the 77th Annual Endocrine Society Meetings, Washington DC, June 14-17, 1995, p.236, #P1-494.

Prins GS, Birch L, Ye S, Ray V: Neonatal estrogen exposure leads to prostate lobe-specific dysplasia and adenomas in the aging rat. American Society of Andrology, Minneapolis, MN, April 25-29, 1996, p. 52, #118.

Prins GS, Birch L, Woodham C, Marmer M, Kuiper G, Gustafsson JA: Estrogen receptor- mRNA ontogeny in the rat prostate lobes and effects of neonatal estrogen exposure on expression pattern. Program of the 79th Annual Endocrine Society Meetings, Minneapolis, MN, June 11-14, 1997, p.542 , #P3-422.

Woodham C, Birch L, Marmer M, Kuiper G, Gustafsson J, Prins GS: Effects of neonatal estrogen exposure on ER mRNA ontogeny in the rat ventral prostate. Gordon Conference Meetings, July 28-August 1, 1997.

Chang WY, Birch L, Prins GS: Neonatal estrogenization stimulates proliferation of a zone of periductal fibroblasts that impede ductal branching and cell-cell interactions in the developing rat ventral prostate. Biology of Prostate Growth Symposium, Bethesda, MD, March 16-18, 1998.

Guerriero G, Prins GS, Birch L, Paolucci M, Botte V, Ciarcia G: Immunocytochemical and biochemical evidence for androgen receptors in the hypothalamus of the male frog, Rana esculenta. Fluctuations throughout the reproductive cycle. Program of the 80th Annual Endocrine Society Meetings, New Orleans, LA, June 24-27, 1998, p.224, #P1-508.

Chang WY, Birch L, Woodham C, Prins GS: Neonatal estrogen exposure alters the TGF- signaling system in the developing rat prostate. 8th Annual Society for Basic Urologic Research Fall Symposium, Prouts Creek, ME, November12-15, 1998.

Kim S, Schwartz C, Birch L, Prins GS: Prostatic growth response to neonatal nonylphenol exposure. EPA Investigator’s Meeting, October 7-9, 1998.

Putz O, Schwartz C, Kim S, Birch L, Prins GS: Prostatic growth response to neonatal exposure of nonylphenol. Keystone Symposia on Molecular and Cellular Biology. Endocrine Disruptors, January 31-February 5, 1999.

Chang WY, Birch L, Prins GS: Neonatal estrogen elevates retinoic acid receptor (RAR) levels in the developing and adult rat ventral prostates. Program of the 81st Annual Endocrine Society Meetings, San Diego, CA, June 12-15, 1999, p.182 , #P1-222.

Habermann H, Birch L, Chang W, Mehta P, Prins GS: Developmental exposure to estrogens alters cell adhesion and gap junction proteins in the adult prostate. American Society of Andrology 2000 Annual Meeting, Boston, MA, Apr 2000.

Habermann H, Birch L, Chang W, Mehta P, Prins GS: Developmental exposure to estrogens alters cell adhesion and gap junction proteins in the adult prostate. American Urological Association 2000 Annual Meeting, Atlanta, GA, Apr-May 2000, p. 34, #2296.

Prins GS, Birch L, Couse J and Korach KS. Developmental estrogenization of the prostate gland is mediated through ERa": Studies with ERKO mice. Program of the 82nd Annual Endocrine Society Meetings, Toronto, Canada, June 21-24, 2000, p.347, #1440.

Habermann H, Chang WY, Birch L, Prins GS: Ontogenese von Connexin 43 and 32 in der rattenprostata und auswirkungen von neonataler ostrogenisierung auf Cx-expression. Duetsche Gesellschaft fur Urologie, Hamburg, Germany, September, 2000.

Habermann H, Mehta PP, Chang WY, Birch L, Prins GS: Connexin 43 and connexin 32 ontogeny in the rat prostate and alterations by neonatal estrogen exposure. 25th World Congress of the Societe Internationale DUrologie, Oct 29-Nov 2, 2000, Singapore.

Gilleran JP, Birch L, Greene GL, Prins GS: Neonatal estrogen exposure decreases ERb protein in the adult rat prostate. American Urologic Association Annual Meeting, Orlando, FL, May 25-30, 2002.

Prins GS, Birch L, Shappell S, Couse J, Korach KS: Aging males lacking estrogen receptor b exhibit increased prostatic lymphocytic infiltration but normal indices of prostatic proliferation in a double-blinded analysis. Program of the 84th Annual Endocrine Society Meetings, San Francisco, CA, June 18-23, 2002, p.500, #P2-207.

Birch L, Prins GS: Neonatal estrogens induce epithelial apoptosis in the developing rat prostate through inhibition of the PI3-Akt pathway. Program of the 85th Annual Endocrine Society Meetings, Philadelphia, PA, June 19-22, 2003, p.405, #P2-406.

Pu Y, Huang L, Birch L, Prins GS: Sonic Hedgehog-Ptc-Gli signaling in developing rat prostate and lobe-specific suppression by neonatal estrogens. Program of the 85th Annual Endocrine Society Meetings, Philadelphia, PA, June 19-22, 2003, p.523, #P3-205.


Lynn A. Birch

University of Illinois at Chicago

Department of Urology; M/C 955

820 S. Wood Street

Chicago, IL  60612-7310

(312) 413 - 7771    Voice Number

(312) 996 - 9649    Fax Number

lbirch@uic.edu       E-mail Address

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