Research goals: To elucidate the pathophysiology of psychiatric disorders which lead to suicide, including mood disorders and schizophrenia. These studies will be conducted by the examination of genetic and transcriptional variation in patients relative to comparison groups. Through these investigations, we aim to identify novel biochemical targets for improved psychotropic medication and biological markers to facilitate diagnosis.

Publications

  1. BOSTROM JA, MOUNT DJ, HAROUTUNIAN V, MEADOR-WOODRUFF JH, SODHI MS. Gender-specific differences in the expression of GABA receptor genes occur in the anterior cingulate cortex in schizophrenia. [In Preparation]
  2. BOSTROM JA and SODHI MS. 2012. A look to the future: epigenetics in psychiatricdisorders and treatment. In Pharmacogenomics: challenges and opportunitiesin therapeutic implementation. Lam, YW and Cavallari, L, Eds.[submitted].
  3. SODHI MS, SIMMONS M, MCCULLUMSMITH R, HAROUTUNIAN V, MEADOR-WOODRUFF JH (2011). Glutamatergic Gene Expression Is Specifically Reduced in Thalamocortical Projecting Relay Neurons in Schizophrenia. Biol Psychiatry. 70(7): 646-54. [Link]
  4. SIMMONS M, MEADOR-WOODRUFF JH, SODHI MS (2010). Increased cortical expression of an RNA editing enzyme occurs in major depressive suicide victims. Neuroreport 21(15):993-7. [Link]
  5. ROTH TL, LUBIN FD, SODHI M, KLEINMAN JE (2009). Epigenetic mechanisms in schizophrenia. Biochim Biophys Acta. 1790(9):869-77. [Link]
  6. SODHI M, WOOD KH, MEADOR-WOODRUFF J (2008). Role of glutamate in schizophrenia: integrating excitatory avenues of research. Expert Rev Neurother. 8(9):1389-406. [Link]
  7. HACKLER EA, AIREY DC, SHANNON CC, SODHI MS, SANDERS-BUSH (2006). 5-HT2C receptor RNA editing in the amygdala of C57BL/6J, DBA/2J, and BALB/cJ mice. Neuroscience Research 55, 96-104. [Link]
  8. SODHI MS, AIREY DC, LAMBERT W, BURNET PW, HARRISON PJ, SANDERS-BUSH E (2005). A rapid new assay to detect RNA editing reveals antipsychotic-induced changes in serotonin-2C transcripts. Mol Pharmacol. 68(3):711-9. [Link]
  9. POOLEY EC, FAIRBURN CG, COOPER Z, SODHI MS, COWEN PJ, HARRISON PJ (2004). A 5-HT2C receptor promoter polymorphism (HT2RC - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. Am J Med Genet B Neuropsychiatr Genet 126, 124-127. [Link]
  10. SODHI MS, SANDERS-BUSH E (2004). Serotonin and brain development. Int Rev Neurobiol. 2004;59:111-74. [Link]
  11. TUNBRIDGE, E., P. W. BURNET, SODHI MS, HARRISON PJ (2004). Catechol-o-methyltransferase(COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression. Synapse 51(2):112-8. [Link]
  12. SODHI MS, BURNET PJ, MAKOFF AJ and HARRISON PJ (2001). RNA editing of the 5-HT2C receptor is reduced in schizophrenia. Molecular Psychiatry, 6 (4), 373-9. [Link]
  13. SODHI MS (2000). The role of the 5-HT2 serotonin receptor subtypes in psychosis: a pharmacogenetic study. Thesis, Kings College, University of London, U.K.
  14. ARRANZ MJ, MUNRO J, BIRKETT J, BOLONNA A, MANCAMA D, SODHI MS, et al. (2000). Pharmacogenetic prediction of clozapine response. Lancet 355: 1615 - 1616. [Link]
  15. SODHI MS, MURRAY RM (1997). Future therapies for schizophrenia. Expert Opinion on Therapeutic Patients 7(2): 151-165. [Link]
  16. ARRANZ MJ, ERDMANN J, KIROV G, RIETSCHEL M, SODHI M, et al. (1997). 5-HT2A receptor and bipolar affective disorder: Association studies in affected patients. Neurosci Lett 224 (2): 95-98. [Link]
  17. COLLIER D, ARRANZ M, SHAM P, BATTERSBY S, GILL P, AITCHISON KJ, SODHI MS, et al. (1996). The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. NeuroReport 7(10):1675-1679. [Link]
  18. ARRANZ MJ, COLLIER DA, MUNRO J, SHAM P, KIROV G, SODHI MS, ROBERTS GW, PRICE J, AND KERWIN RW (1996). Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine. Neuroscience Letters 217:177-178.[Link]
  19. SODHI MS, ARRANZ MJ, CURTIS DA, SHAM PC, BALL DM, ROBERTS GW, PRICE J, COLLIER DA AND KERWIN RW (1995). Association between clozapine response and allelic variation in the 5-HT2C receptor gene. NeuroReport 7(1): 169-172. [Link]
  20. ARRANZ MJ, COLLIER D, SODHI MS, BALL DM, ROBERTS GW, PRICE J, SHAM P AND KERWIN R (1995). Association between clozapine response and allelic variation in the 5-HT2A receptor gene. Lancet, 346: 281-282. [Link]

 

Important Dates

4/19/12: CPB Department Seminar: "Control of energy metabolism by editing of serotonin receptor mRNAs". Kazuko Nishikura. 12PM, 1st Floor Auditorium MBRB.

2/22/12: BPS Department Seminar "Disrupted RNA Editing of the Glutamate and Serotonin Systems in Psychiatric Disorders." PHAR 134-3.

12/5/11 - 12/9/11: 50th Annual Meeting for the American College of Neuropsycho- pharmacology (ACNP).

11/12/11 - 11/16/11: Society for Neuroscience Annual Meeting (SfN).

9/28/11: UAB Psychology Colloqium Series Presentation: "Decoding Mixed Messages in Schizophrenia and Depression."