EDUCATION:
1992-94 Post-doctoral Fellow/ Research Associate, Pharmacology, Mayo Clinic
Jacksonville, Jacksonville, FL, USA (with Dr. M. McKinney)
1988-89 Post-doctoral Fellow/ Research Associate, Department of Pharmacology,
Southern Illinois University, School of Medicine, Springfield, IL, USA (with
Dr. E. Giacobini)
1985-88 Ph.D., Department of Pharmacology, Faculty of Pharmaceutical Sciences,
Science University of Tokyo, Tokyo, Japan
1983-85 M.S., Department of Pharmacology, Faculty of Pharmaceutical Sciences,
Science University of Tokyo, Tokyo, Japan
1979-83 B.S., Department of Pharmacology, Faculty of Pharmaceutical Sciences,
Science University of Tokyo, Tokyo, Japan
APPOINTMENTS:
2003- Associate Professor with Tenure, Department of Psychiatry, The
University of Illinois at Chicago, Chicago, IL, USA
2003- Associate Professor with Tenure, Department of Physiology and Biophysics,
The University of Illinois at Chicago, Chicago, IL, USA
2003- Adjunct Associate Professor of Ophthalmology with Tenure, Department
of Ophthalmology, The University of Illinois at Chicago, Chicago, IL, USA
2003- Adjunct Associate Professor of Bioengineering with Tenure, Department
of Bioengineering, The University of Illinois at Chicago, Chicago, IL,
USA
2002- Founder, Chairman of the Board and CSO, NewNeural Inc., Chicago,
IL, USA
2001-2002 Adjunct Assistant Professor of Ophthalmology, Department of Ophthalmology,
The University of Illinois at Chicago, Chicago, IL, USA
1999-2002 Assistant Professor, Department of Psychiatry, The University
of Illinois at Chicago, Chicago, IL, USA
1999-2002 Assistant Professor, Department of Physiology and Biophysics,
The University of Illinois at Chicago, Chicago, IL, USA
1997-1999 Research Assistant Professor, Department of Psychiatry, The University
of Illinois at Chicago, Chicago, IL, USA
1997-1999 Principal Investigator, Research and Development Service, West
Side VA Medical Center at Chicago, Chicago, IL, USA
1997 Assistant Professor, Pharmacology, Mayo Clinic, Jacksonville, FL,
USA
1994-97 Associate Consultant, Neuropharmacology, Mayo Clinic Jacksonville,
Jacksonville, FL, USA
1993-94 Research Associate, Neuropharmacology, Mayo Clinic Jacksonville,
Jacksonville, FL, USA
1992-93 Research Fellow, Neuropharmacology, Mayo Clinic Jacksonville, Jacksonville,
FL, USA
1991-92 Full-time Lecturer, Division of Aging and Intractable Diseases,
Research Institute for Biosciences, Science University of Tokyo, Noda,
Chiba, Japan
1989-91 Senior Staff Research Associate, Division of Aging and Intractable
Diseases, Research Institute for Biosciences, Science University of Tokyo,
Noda, Chiba, Japan
1988-89 Research Associate, Department of Pharmacology, Southern Illinois
University, School of Medicine, Springfield, IL, USA
TEACHING EXPERIENCE:
2000- Human physiology lectures for pharmacy students (PHYB 301), Department
of Physiology and Biophysics, University of Illinois at Chicago, Chicago,
IL, USA
2000- Human physiology lectures for dental students (PHYB 321), Department
of Physiology and Biophysics, University of Illinois at Chicago, Chicago,
IL, USA
1999- Topics of Neuroscience for PGY-1 Residents, Department of Psychiatry,
University of Illinois at Chicago, Chicago, IL, USA
1998-1999 Training Course for Aging, Residents of Psychiatry, Department
of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
1997 Graduate course of Pharmacology, Department of Pharmacology, Mayo Clinic,
Rochester, MN, USA
1989-92 Graduate course of Pharmacology, Course organizer, Department of
Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo,
Tokyo, Japan
1989-92 Under Graduate course of Pharmacology, Course organizer, Department
of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of
Tokyo, Tokyo, Japan
Medical Students: Hojoong M. Kim, Anthony Gray. Ankur V. Vaghani, Jamey E.
, Eklund, Louis C. Keiler
Graduate Students: Masanori Takahashi (Ph.D.), Akiko Mizukami (M.S.), Kwak,
Young-Don (Ph.D. student), Tomoharu Inoue, (Ph.D. student), Srikanth B. Yellanki
(Ph.D. student), Yan Zhuang (M.S. student),
Post-doctoral Fellows: S. Sujyung, M.D., Ph.D. , Tingyu Qu, M.D., Ph.D.,
X. Don, Ph.D, Hiroko Koike, M.D., Ph.D.
PROFESSIONAL SOCIETIES:
Society for Neuroscience
American Association for the Advancement of Science
The Association for Research in Vision and Opthalmology
Sigma Xi
The Japanese Pharmacological Society
The Japanese Society of Neuropsychopharmacology
FUNDINGS
1989-1992 Pharmacological Study of agonist and antagonist of cholecystokinin.
Co-investigator. Torii & Co., Ltd.
1990 Study of cholecystokinin as a anti-dementia drug. Principal Investigator.
Science University of Tokyo
1990 Basic study of Senescence Accelerated Mouse as a CNS aging model animal.
Co-investigator. Asahi Breweries, Ltd.
1990 Effect of FTS on the CNS aging of Senescence Accelerated Mouse. Principal
Investigator. Mitsui Pharmaceuticals Inc.
1990-1992 Development of a new instrument for the neurotransmitter release
from the brain slice. Principal Investigator. Muromach Kikai Co. Ltd.
1990-1993 Pharmacological study of "Kaketsukeo". Principal Investigator.
Iskra Industry Co., Ltd.
1991 The computerized control and database system for an animal center. Principal
Investigator. The Telecommunications Advancement Foundation
1991 Effect of NGF releaser on the cholinergic degeneration in NBM lesion
rat. Principal Investigator. Mitsui Pharmaceuticals Inc.
1992 Study of the FTS binding site in rat. Principal Investigator. Mitsui
Pharmaceuticals Inc.
1992-1993 Early diagnosis of Alzheimer's disease by abnormal protein. Principal
Investigator. Fujisawa Pharmaceutical Co., Ltd.
1994-1995 Exploration of specific marker for Alzheimer’s disease. Principal
Investigator. Fujisawa Pharmaceutical Co., Ltd.
1995 Is apoptosis a major cause of neuronal death in Alzheimer’s disease?
Principal Investigator. Florida State Memory Disorder Clinic
1995-1996 Identification of specific proteins in the blood of insulin resistant
subject with and without diabetics mellitus. Collaborator. Fujisawa Pharmaceutical
Co., Ltd.
1999 5-Lipoxygenase gene polymorphism and onset of Alzheimers. Co-investigator,
Campus Research Board Funding, The University of Illinois at Chicago
1999-2001 Glial activation in aged memory impaired rats (R03AG16474), Principal
Investigator, NIH
1999-2001 Reward Deficiency ERPs: Effects of D2A1, Gambling Pathology & ADHD,
Co-investigator, National Center for Responsible Gambling
2001-2002 Effect of APP on Human Neural Stem Cell Biology, Principal Investigator,
CRB Funding, The University of Illinois at Chicago
2001-2003 Basic study of neural replacement therapy for Alzheimer’s
disease (R03AG19874), Principal Investigator, NIH
2002-2004 Production of human retinal cells from mesenchymal (bone marrow)
stem cells, Principal Investigator, Mcgraw Foundation
2002-2006 Interactive multiple gene expression map (1 R01AG20011-01), Principal
Investigator, NIH.
2002- Neuroreplacement therapy for Parkinson's disease. Principal Investigator,
the Boothroyd Foundation
2003 Neural stem cells transplantation into a non-human primate model of
stroke, Co-investigator, CRB Funding, The University of Illinois at Chicago
2003-2008 Neuroreplacement strategies by mesenchymal stem cell (1 R01 AG
23472-01), Principal Investigator, NIH.
2003-2004 Stem cell transplantation for ALS model mouse, Principal Investigator,
The ALS Therapy Development Foundation, collaborative research
2003-2006 Beta-amyloid precursor protein function in stem cell biology (IIRG-03-5577),
Principal Investigator, Alzheimer Association.
Pending Autologous stem cell therapy for retinal regeneration, (R41 EY015619-01),
Principal Investigator, NIH
Pending Enhanced Neural Stem Cell Production in Aging Brain, (R43 AG023998-01),
Co-investigator, NIH
Pending Adult Marrow Stem Cells for Neuro-Replacement Therapy (R43 NS048625-01),
Co-investigator, NIH
MANUSCRIPT REVIEWER
The Japanese Journal of Pharmacology, Neurochemistry International, Restorative
Neurology and Neuroscience. Biochemical Pharmacology, Experimental Neurology,
Drugs, Cellular and Molecular Life Sciences, Journal Informatics, NeuroImage,
Cytology, Neurobiology of Aging
GRANT REVIEWER
2000- Alzheimer Association Research Grant
2000- CRB grant at UIC
2003- NIH study section, SSS-E Human Brain Project
PATENTS
1. (WO94/10205) Specific protein markers for Alzheimer’s disease and
diagnosis method for Alzheimer’s disease using the specific markers.
2. (WO95/05395) Diagnosis method for Alzheimer’s disease.
3. (WO 03/060085) NOVEL MAMMALIAN MULTIPOTENT NEURAL STEM CELLS AND COMPOSITIONS,
METHODS OF PREPARATION AND METHODS OF ADMINISTRATION THEREOF
4. (WO 03/060082) USE OF MODIFIED PYRIMIDINE COMPOUNDS TO PROMOTE STEM CELL
MIGRATION AND PROLIFERATION
5. (WO 03/059276) NOVEL MAMMALIAN MULTIPOTENT STEM CELLS AND COMPOSITIONS,
METHODS OF PREPARATION AND METHODS OF ADMINISTRATION THEREOF