carley profile

	David W. Carley, PhD Professor, Medical-Surgical Nursing, Medicine and Bioengineering Director, Center for Narcolepsy, Sleep and Health Research
CAMPUS ADDRESS Center for Narcolepsy, Sleep and Health Research College of Nursing, Suite 208 University of Illinois at Chicago 845 South Damen Avenue (M/C 802) Chicago, IL 60612 dwcarley@uic.edu
RESEARCH INTERESTS Neuroscience of Sleep and Breathing Sleep-Related Breathing Disorders Animal Models of Disease, Drug Discovery, Mathematical Modeling UIC News Release My research focuses on the neurobiology of sleep and breathing, with long-range goals aimed at understanding the causes and consequences of sleep-disordered breathing (e.g. sleep apnea syndrome) and developing improved diagnostic and therapeutic options for these clinical disorders. I conduct basic animal investigations to identify and characterize the neural networks responsible for modifying the regulation of breathing pattern in differing sleep/wake states. These studies also aim to identify specific derangements of the nervous system that may lead to clinical disorders such as sleep apnea syndrome. In collaboration with Miodrag Radulovacki, Professor of Pharmacology, I have developed an animal model of sleep-disordered breathing and am using this model to test putative drug treatments for sleep apnea. This approach already has led to promising findings in a proof of concept study for one drug-candidate in 12 patients with sleep apnea. We are now conducting two additional clinical trials with related formulations in a larger number of patients. I am also studying the pathophysiology of sleep-disordered breathing in human studies involving healthy control volunteers and patients with sleep apnea syndrome.
PROFESSIONAL BACKGROUND 1985 - 1986 Assistant in Biomedical Engineering and Pediatrics Massachusetts General Hospital, Boston, MA 1985 - 1986 Instructor in Pediatrics and Biomedical Engineering Harvard Medical School, Boston, MA 1986 - 1988 Research Instructor University of Illinois College of Medicine at Chicago 1988 - 1991 Research Assistant Professor in Medicine University of Illinois College of Medicine at Chicago 1989 - Executive Director of Respiratory Research Section of Respiratory and Critical Care Medicine University of Illinois College of Medicine at Chicago 1990 - Director of Research Center for Sleep and Ventilatory Disorders University of Illinois Hospital 1991 - 2000 Research Associate Professor of Medicine University of Illinois College of Medicine at Chicago 1993 - 2000 Research Associate Professor of Pharmacology University of Illinois College of Medicine at Chicago 1998 - 2000 Associate Professor of Bioengineering University of Illinois at Chicago College of Engineering 2000 - 2005 Professor of Medicine, Bioengineering and Pharmacology University of Illinois at Chicago 2005 - Professor of Medical-Surgical Nursing, Medicine, Bioengineering and Pharmacology Director, Center for Narcolepsy, Sleep and Health Research University of Illinois at Chicago
EDUCATION AND TRAINING 1978 BSEE State University of New York at Stony Brook (Electrical Eng.) 1982 SM Massachusetts Institute of Technology (Electrical Eng.) 1985 Ph.D. Massachusetts Institute of Technology and Harvard University (Medical Engineering/Medical Physics)
PERSONAL INTERESTS AND ACCOMPLISHMENTS Away from the office and lab, things that I enjoy include bicycling, windsurfing, sailing and backpack camping. Happily, these are not all mutually exclusive. After graduate school, I spent a summer cycling with my camping gear around Europe. More recently, I spent a week riding from Minneapolis to Chicago and camping along the way. Sailing and windsurfing also go well together, and we launch a Laser and 2 sailboards from the Evanston beach. Each of these outdoor activities also provides opportunities for amateur photography, a childhood interest that is making a comeback for me in "the digital age."
REPRESENTATIVE PUBLICATIONS Carley DW and DC Shannon. A minimal model of human periodic breathing. J Appl Physiol 65:1400-1409, 1988. Carley DW, E Önal, RM Aronson and M Lopata. Breath by breath interactions between inspiratory and expiratory duration in occlusive sleep apnea. J Appl Physiol 66:2312-2319, 1989. Carlson DM, DW Carley, E Önal, M Lopata and RC Basner. Acoustically induced transient arousal increases pharyngeal and diaphragm muscle phasic EMG in normals. J Appl Physiol 76:1553 - 1559, 1994. Carley DW, SM Trbovic, A Bozanich and M Radulovacki. Cardiopulmonary control in sleeping Sprague-Dawley rats treated with hydralazine. J Appl Physiol 83:1954-1960, 1997. Carley, DW and M Radulovacki. Role of peripheral serotonin in the regulation of central sleep apneas in rats. Chest , 115:1397-1401, 1999. Carley DW, K Berecek, A Videnovic and M Radulovacki. Sleep disordered respiration in phenotypically normotensive, genetically hypertensive rats. Am J Resp Crit Care Med 162: 1474-1479, 2000. Carley, DW, S Pavlovic, M Janelidze and M Radulovacki. Functional role for cannabinoids in respiratory stability during sleep. Sleep, 25:391-398, 2002. Saponjic, J, M Radulovacki, DW Carley. Respiratory pattern modulation by the pedunculopontine tegmental nucleus. Respiratory Physiology and Neurobiology, 138:223-237, 2003. Radulovacki, M, S Pavlovic, J Saponjic and DW Carley. Modulation of reflex and sleep related apnea by pedunculopontine tegmental and intertrigeminal neurons. Resp Physiol Neurobiol, 143:293-306, 2004. Saponjic, J, J Cvorovic, M Radulovacki and DW Carley. Serotonin and noradrenaline modulate respiratory pattern disturbances evoked by glutamate injection into pedunculopontine tegmentum of anesthetized rats. Sleep, 28:560-570, 2005.
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